Search Results - "Alcazar, Jose Antonio"

Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient by Cordero, Mario D., B.S, Cotán, David, Ph.D, del-Pozo-Martín, Yaiza, B.S, Carrión, Angel M., Ph.D, de Miguel, Manuel, Ph.D, Bullón, Pedro, M.D., Ph.D, Sánchez-Alcazar, José Antonio, M.D., Ph.D

“…Abstract Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology. Recent studies have shown evidence demonstrating that mitochondrial dysfunction…”
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AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome by Bullón, Pedro, Alcocer-Gómez, Elísabet, Carrión, Angel M, Marín-Aguilar, Fabiola, Garrido-Maraver, Juan, Román-Malo, Lourdes, Ruiz-Cabello, Jesus, Culic, Ognjen, Ryffel, Bernhard, Apetoh, Lionel, Ghiringhelli, François, Battino, Maurizio, Sánchez-Alcazar, José Antonio, Cordero, Mario D

“…Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome…”
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Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome by Alcocer-Gómez, Elísabet, Ulecia-Morón, Cristina, Marín-Aguilar, Fabiola, Rybkina, Tatyana, Casas-Barquero, Nieves, Ruiz-Cabello, Jesús, Ryffel, Bernhard, Apetoh, Lionel, Ghiringhelli, François, Bullón, Pedro, Sánchez-Alcazar, José Antonio, Carrión, Angel M., Cordero, Mario D.

“…Depression is a major public health concern in modern society, yet little is known about the molecular link between this condition and neuroinflammation. The…”
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Mutation in cytochrome b gene of mitochondrial DNA in a family with fibromyalgia is associated with NLRP3-inflammasome activation by Cordero, Mario D, Alcocer-Gómez, Elísabet, Marín-Aguilar, Fabiola, Rybkina, Tatyana, Cotán, David, Pérez-Pulido, Antonio, Alvarez-Suarez, José Miguel, Battino, Maurizio, Sánchez-Alcazar, José Antonio, Carrión, Angel M, Culic, Ognjen, Navarro-Pando, José M, Bullón, Pedro

“…Fibromyalgia (FM) is a worldwide diffuse musculoskeletal chronic pain condition that affects up to 5% of the general population. Many symptoms associated with…”
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Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients by Moreno-Fernández, Ana M, Cordero, Mario D, Garrido-Maraver, Juan, Alcocer-Gómez, Elísabet, Casas-Barquero, Nieves, Carmona-López, María I, Sánchez-Alcázar, José Antonio, de Miguel, Manuel

“…Abstract Amitriptyline is a commonly prescribed tricyclic antidepressant, which has been shown to impair mitochondrial function and increase oxidative stress…”
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Aging‐Related Changes in Inflammatory and LKB1/AMPK Gene Expression in Fibromyalgia Patients by Alcocer‐Gómez, Elísabet, Sánchez‐Alcazar, José Antonio, Battino, Maurizio, Bullón, Pedro, Cordero, Mario D.

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Amitriptyline induces coenzyme Q deficiency and oxidative damage in mouse lung and liver by Bautista-Ferrufino, María Rosa, Cordero, Mario D., Sánchez-Alcázar, José Antonio, Illanes, Matilde, Fernández-Rodríguez, Ana, Navas, Plácido, de Miguel, Manuel

“…► Coenzyme Q (CoQ) has been proposed as a mitochondrial dysfunction marker. ► The antidepressant amitriptyline (Amit) increases oxidative stress, altering…”
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Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: Implications for regulation of BMP signalling by Lopez-Escobar, Beatriz, De Felipe, Beatriz, Sanchez-Alcazar, Jose Antonio, Sasaki, Takako, Copp, Andrew J., Ybot-Gonzalez, Patricia

“…Background: The ventral ectodermal ridge (VER) is an important signalling centre in the mouse tail‐bud following completion of gastrulation. BMP regulation is…”
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NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder by Alcocer-Gómez, Elísabet, de Miguel, Manuel, Casas-Barquero, Nieves, Núñez-Vasco, Jéssica, Sánchez-Alcazar, José Antonio, Fernández-Rodríguez, Ana, Cordero, Mario D

“…Highlight • Activation of inflammasome in major depressive disorder provide new insights into the pathogenesis and may represent a new therapeutic option for…”
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Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients by Cordero, Mario D., Moreno-Fernández, Ana M., Carmona-López, María I., Sánchez-Alcázar, José Antonio, Rodríguez, Ana Fernández, Navas, Plácido, de Miguel, Manuel

“…Coenzyme Q 10 (CoQ 10) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Signs associated with skin alteration…”
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Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder by Alcocer-Gómez, Elísabet, Casas-Barquero, Nieves, Williams, Matthew R., Romero-Guillena, Samuel L., Cañadas-Lozano, Diego, Bullón, Pedro, Sánchez-Alcazar, José Antonio, Navarro-Pando, José M., Cordero, Mario D.

“…[Display omitted] Major Depressive Disorder (MDD, ICD-10: F-33) is a prevalent illness in which the pathogenic mechanism remains elusive. Recently an important…”
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Genomic characterization of liver metastases from colorectal cancer patients by Sayagués, José María, Corchete, Luís Antonio, Gutiérrez, María Laura, Sarasquete, Maria Eugenia, Del Mar Abad, María, Bengoechea, Oscar, Fermiñán, Encarna, Anduaga, María Fernanda, Del Carmen, Sofia, Iglesias, Manuel, Esteban, Carmen, Angoso, María, Alcazar, Jose Antonio, García, Jacinto, Orfao, Alberto, Muñoz-Bellvis, Luís

“…Metastatic dissemination is the most frequent cause of death of sporadic colorectal cancer (sCRC) patients. Genomic abnormalities which are potentially…”
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Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation by del Carmen, Sofía, Corchete, Luís Antonio, Gervas, Ruth, Rodriguez, Alba, Garcia, María, Álcazar, José Antonio, García, Jacinto, Bengoechea, Oscar, Muñoz-Bellvis, Luis, Sayagués, José María, Abad, Mar

“…Sporadic colorectal cancer (sCRC) is the third most frequent cancer worldwide and the second most common cause of cancer-related deaths (mainly due metastatic…”
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Genomics and proteomics approaches for biomarker discovery in sporadic colorectal cancer with metastasis by González-González, María, Garcia, Jacinto Garcia, Montero, José Antonio Alcazar, Fernandez, Luis Miguel González, Bengoechea, Oscar, Muñez, Oscar Blanco, Orfao, Alberto, Sayagues, J M, Fuentes, Manuel

“…Sporadic colorectal cancer (sCRC) is one of the most frequent types of cancer in Europe. Despite understanding of its tumorigenesis, the metastatic process is…”
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Spatio-temporal tumor heterogeneity in metastatic CRC tumors: a mutational-based approach by Del Carmen, Sofía, Sayagués, José María, Bengoechea, Oscar, Anduaga, María Fernanda, Alcazar, Jose Antonio, Gervas, Ruth, García, Jacinto, Orfao, Alberto, Bellvis, Luis Muñoz, Sarasquete, María Eugenia, Del Mar Abad, María

“…It is well known that activating mutations in the and genes are associated with poor response to anti-EGFR therapies in patients with metastatic colorectal…”
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The MELAS mutation m.3243A>G alters the expression of mitochondrial tRNA fragments by Meseguer, Salvador, Navarro-González, Carmen, Panadero, Joaquin, Villarroya, Magda, Boutoual, Rachid, Sánchez-Alcázar, Jose Antonio, Armengod, M.-Eugenia

“…Recent evidences highlight the importance of mitochondria-nucleus communication for the clinical phenotype of oxidative phosphorylation (OXPHOS) diseases…”
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Dysregulated Expression of Three Genes in Colorectal Cancer Stratifies Patients into Three Risk Groups by Rodriguez, Alba, Corchete, Luís Antonio, Alcazar, José Antonio, Montero, Juan Carlos, Rodriguez, Marta, Chinchilla-Tábora, Luis Miguel, Vidal Tocino, Rosario, Moyano, Carlos, Muñoz-Bravo, Saray, Sayagués, José María, Abad, Mar

“…Despite advances in recent years in the study of the molecular profile of sporadic colorectal cancer (sCRC), the specific genetic events that lead to increased…”
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High-Risk Clinicopathological and Genetic Features and Outcomes in Patients Receiving Neoadjuvant Radiochemotherapy for Locally Advanced Rectal Cancer by Del Carmen, Sofía, Corchete, Luís Antonio, González Velasco, Cristina, Sanz, Julia, Alcazar, José Antonio, García, Jacinto, Rodríguez, Ana Isabel, Vidal Tocino, Rosario, Rodriguez, Alba, Pérez-Romasanta, Luis Alberto, Sayagués, José María, Abad, Mar

“…Administering preoperative radiochemotherapy (RCT) in stage II-III tumors to locally advanced rectal carcinoma patients has proved to be effective in a high…”
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mtUPR Modulation as a Therapeutic Target for Primary and Secondary Mitochondrial Diseases by Cilleros-Holgado, Paula, Gómez-Fernández, David, Piñero-Pérez, Rocío, Reche-López, Diana, Álvarez-Córdoba, Mónica, Munuera-Cabeza, Manuel, Talaverón-Rey, Marta, Povea-Cabello, Suleva, Suárez-Carrillo, Alejandra, Romero-González, Ana, Suárez-Rivero, Juan Miguel, Romero-Domínguez, Jose Manuel, Sánchez-Alcázar, Jose Antonio

“…Mitochondrial dysfunction is a key pathological event in many diseases. Its role in energy production, calcium homeostasis, apoptosis regulation, and reactive…”
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Tracking the Antibody Immunome in Sporadic Colorectal Cancer by Using Antigen Self-Assembled Protein Arrays by González-González, María, Sayagués, José María, Muñoz-Bellvís, Luis, Pedreira, Carlos Eduardo, de Campos, Marcello L. R., García, Jacinto, Alcázar, José Antonio, Braz, Patrick F., Galves, Breno L., González, Luis Miguel, Bengoechea, Oscar, Abad, María del Mar, Cruz, Juan Jesús, Bellido, Lorena, Fonseca, Emilio, Díez, Paula, Juanes-Velasco, Pablo, Landeira-Viñuela, Alicia, Lecrevisse, Quentin, Montalvillo, Enrique, Góngora, Rafael, Blanco, Oscar, Sánchez-Santos, José Manuel, LaBaer, Joshua, Orfao, Alberto, Fuentes, Manuel

“…Sporadic Colorectal Cancer (sCRC) is the third leading cause of cancer death in the Western world, and the sCRC patients presenting with synchronic metastasis…”
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