Search Results - "Alcaraz, Lindsay"

Latent TGF-β Activation Is a Hallmark of the Tenascin Family by Aubert, Alexandre, Mercier-Gouy, Perrine, Aguero, Stéphanie, Berthier, Laurent, Liot, Sophie, Prigent, Laura, Alcaraz, Lindsay B., Verrier, Bernard, Terreux, Raphaël, Moali, Catherine, Lambert, Elise, Valcourt, Ulrich

“…Transforming growth factor-β (TGF-β) isoforms are secreted as inactive complexes formed through non-covalent interactions between bioactive TGF-β entities and…”
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Trpv6 channel targeting using monoclonal antibody induces prostate cancer cell apoptosis and tumor regression by Haustrate, Aurélien, Cordier, Clément, Shapovalov, George, Mihalache, Adriana, Desruelles, Emilie, Soret, Benjamin, Essonghé, Nadège Charlène, Spriet, Corentin, Yassine, Maya, Barras, Alexandre, Marines, Johanna, Alcaraz, Lindsay B., Szunerits, Sabine, Robin, Gautier, Gosset, Pierre, Prevarskaya, Natalia, Lehen’kyi, V’yacheslav

“…TRPV6 calcium channel is a prospective target in prostate cancer (PCa) since it is not expressed in healthy prostate while its expression increases during…”
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A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment by Alcaraz, Lindsay B, Mallavialle, Aude, David, Timothée, Derocq, Danielle, Delolme, Frédéric, Dieryckx, Cindy, Mollevi, Caroline, Boissière-Michot, Florence, Simony-Lafontaine, Joëlle, Du Manoir, Stanislas, Huesgen, Pitter F, Overall, Christopher M, Tartare-Deckert, Sophie, Jacot, William, Chardès, Thierry, Guiu, Séverine, Roger, Pascal, Reinheckel, Thomas, Moali, Catherine, Liaudet-Coopman, Emmanuelle

“…Alternative therapeutic strategies based on tumor-specific molecular targets are urgently needed for triple-negative breast cancer (TNBC). The protease…”
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Anti-cathepsin D immunotherapy triggers both innate and adaptive anti-tumour immunity in breast cancer by David, Timothée, Mallavialle, Aude, Faget, Julien, Alcaraz, Lindsay B, Lapierre, Marion, du Roure, Pénélope Desroys, Laurent-Matha, Valérie, Mansouri, Hanane, Jarlier, Marta, Martineau, Pierre, Roger, Pascal, Guiu, Séverine, Chardès, Thierry, Liaudet-Coopman, Emmanuelle

“…Triple-negative breast cancer (TNBC) has poorer outcomes than other breast cancers (BC), including HER2 BC. Cathepsin D (CathD) is a poor prognosis marker…”
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Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-β by Alcaraz, Lindsay B, Exposito, Jean-Yves, Chuvin, Nicolas, Pommier, Roxane M, Cluzel, Caroline, Martel, Sylvie, Sentis, Stéphanie, Bartholin, Laurent, Lethias, Claire, Valcourt, Ulrich

“…Transforming growth factor β (TGF-β) isoforms are secreted as inactive complexes formed through noncovalent interactions between the bioactive TGF-β entity and…”
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SPARC in cancer‐associated fibroblasts is an independent poor prognostic factor in non‐metastatic triple‐negative breast cancer and exhibits pro‐tumor activity by Alcaraz, Lindsay B., Mallavialle, Aude, Mollevi, Caroline, Boissière‐Michot, Florence, Mansouri, Hanane, Simony‐Lafontaine, Joelle, Laurent‐Matha, Valérie, Chardès, Thierry, Jacot, William, Turtoi, Andrei, Roger, Pascal, Guiu, Séverine, Liaudet‐Coopman, Emmanuelle

“…Triple‐negative breast cancer (TNBC) is the most aggressive breast cancer subtype and lacks specific targeted therapeutic agents. The current mechanistic…”
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TIF1γ Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability by Pommier, Roxane M, Gout, Johann, Vincent, David F, Alcaraz, Lindsay B, Chuvin, Nicolas, Arfi, Vanessa, Martel, Sylvie, Kaniewski, Bastien, Devailly, Guillaume, Fourel, Geneviève, Bernard, Pascal, Moyret-Lalle, Caroline, Ansieau, Stéphane, Puisieux, Alain, Valcourt, Ulrich, Sentis, Stéphanie, Bartholin, Laurent

“…The transcription accessory factor TIF1γ/TRIM33/RFG7/PTC7/Ectodermin functions as a tumor suppressor that promotes development and cellular differentiation…”
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Tenascin-X: beyond the architectural function by Valcourt, Ulrich, Alcaraz, Lindsay B, Exposito, Jean-Yves, Lethias, Claire, Bartholin, Laurent

“…Tenascin-X is the largest member of the tenascin (TN) family of evolutionary conserved extracellular matrix glycoproteins, which also comprises TN-C, TN-R and…”
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A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer by Desroys du Roure, Pénélope, Lajoie, Laurie, Mallavialle, Aude, Alcaraz, Lindsay B, Mansouri, Hanane, Fenou, Lise, Garambois, Véronique, Rubio, Lucie, David, Timothée, Coenon, Loïs, Boissière-Michot, Florence, Chateau, Marie-Christine, Ngo, Giang, Jarlier, Marta, Villalba, Martin, Martineau, Pierre, Laurent-Matha, Valérie, Roger, Pascal, Guiu, Séverine, Chardès, Thierry, Gros, Laurent, Liaudet-Coopman, Emmanuelle

“…Triple-negative breast cancer (TNBC) prognosis is poor. Immunotherapies to enhance the antibody-induced natural killer (NK) cell antitumor activity are…”
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Co-Expression of Androgen Receptor and Cathepsin D Defines a Triple-Negative Breast Cancer Subgroup with Poorer Overall Survival by Mansouri, Hanane, Alcaraz, Lindsay B, Mollevi, Caroline, Mallavialle, Aude, Jacot, William, Boissière-Michot, Florence, Simony-Lafontaine, Joelle, Laurent-Matha, Valérie, Roger, Pascal, Liaudet-Coopman, Emmanuelle, Guiu, Séverine

“…In the triple-negative breast cancer (TNBC) group, the luminal androgen receptor subtype is characterized by expression of androgen receptor (AR) and lack of…”
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Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics by Delolme, Frédéric, Anastasi, Cyril, Alcaraz, Lindsay B, Mendoza, Valentin, Vadon-Le Goff, Sandrine, Talantikite, Maya, Capomaccio, Robin, Mevaere, Jimmy, Fortin, Laëtitia, Mazzocut, Dominique, Damour, Odile, Zanella-Cléon, Isabelle, Hulmes, David J. S, Overall, Christopher M, Valcourt, Ulrich, Lopez-Casillas, Fernando, Moali, Catherine

“…The metalloproteinase BMP-1 (bone morphogenetic protein-1) plays a major role in the control of extracellular matrix (ECM) assembly and growth factor…”
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Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies by Ashraf, Yahya, Mansouri, Hanane, Laurent-Matha, Valérie, Alcaraz, Lindsay B, Roger, Pascal, Guiu, Séverine, Derocq, Danielle, Robin, Gautier, Michaud, Henri-Alexandre, Delpech, Helène, Jarlier, Marta, Pugnière, Martine, Robert, Bruno, Puel, Anthony, Martin, Lucie, Landomiel, Flavie, Bourquard, Thomas, Achour, Oussama, Fruitier-Arnaudin, Ingrid, Pichard, Alexandre, Deshayes, Emmanuel, Turtoi, Andrei, Poupon, Anne, Simony-Lafontaine, Joëlle, Boissière-Michot, Florence, Pirot, Nelly, Bernex, Florence, Jacot, William, du Manoir, Stanislas, Theillet, Charles, Pouget, Jean-Pierre, Navarro-Teulon, Isabelle, Bonnefoy, Nathalie, Pèlegrin, André, Chardès, Thierry, Martineau, Pierre, Liaudet-Coopman, Emmanuelle

“…Triple-negative breast cancer (TNBC) treatment is currently restricted to chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic…”
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Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRAS G12D -driven Pancreatic Tumorigenesis by Chuvin, Nicolas, Vincent, David F, Pommier, Roxane M, Alcaraz, Lindsay B, Gout, Johann, Caligaris, Cassandre, Yacoub, Karam, Cardot, Victoire, Roger, Elodie, Kaniewski, Bastien, Martel, Sylvie, Cintas, Celia, Goddard-Léon, Sophie, Colombe, Amélie, Valantin, Julie, Gadot, Nicolas, Servoz, Emilie, Morton, Jennifer, Goddard, Isabelle, Couvelard, Anne, Rebours, Vinciane, Guillermet, Julie, Sansom, Owen J, Treilleux, Isabelle, Valcourt, Ulrich, Sentis, Stéphanie, Dubus, Pierre, Bartholin, Laurent

“…Transforming growth factor beta (TGFβ) acts either as a tumor suppressor or as an oncogene, depending on the cellular context and time of activation. TGFβ…”
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Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D -driven Pancreatic Tumorigenesis by Chuvin, Nicolas, Vincent, David F, Pommier, Roxane M, Alcaraz, Lindsay B, Gout, Johann, Caligaris, Cassandre, Yacoub, Karam, Cardot, Victoire, Roger, Elodie, Kaniewski, Bastien, Martel, Sylvie, Cintas, Celia, Goddard-Léon, Sophie, Colombe, Amélie, Valantin, Julie, Gadot, Nicolas, Servoz, Emilie, Morton, Jennifer, Goddard, Isabelle, Couvelard, Anne, Rebours, Vinciane, Guillermet, Julie, Sansom, Owen J, Treilleux, Isabelle, Valcourt, Ulrich, Sentis, Stéphanie, Dubus, Pierre, Bartholin, Laurent

“…Background & Aims Transforming growth factor beta (TGFβ) acts either as a tumor suppressor or as an oncogene, depending on the cellular context and time of…”
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Anti-cathepsin D immunotherapy triggers both innate and adaptive anti-tumour immunity in breast cancer: Antibody-based immunomodulatory therapy of breast cancer by David, Timothée, Mallavialle, Aude, Faget, Julien, Alcaraz, Lindsay B, Lapierre, Marion, Du Roure, Pénélope Desroys, Laurent-Matha, Valérie, Mansouri, Hanane, Jarlier, Marta, Martineau, Pierre, Roger, Pascal, Guiu, Séverine, Chardès, Thierry, Liaudet-Coopman, Emmanuelle

“…Background and purpose: Triple-negative breast cancer (TNBC) has poorer outcomes than other breast cancer (BC) subtypes, including HER2+ BC. Cathepsin D…”
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Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β by Valcourt, Ulrich, Carthy, Jonathon, Okita, Yukari, Alcaraz, Lindsay, Kato, Mitsuyasu, Thuault, Sylvie, Bartholin, Laurent, Moustakas, Aristidis

“…In recent years, the importance of the cell biological process of epithelial-mesenchymal transition (EMT) has been established via an exponentially growing…”
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Abstract P6-05-11: Prognostic value of androgen receptor and cathepsin D co-expression in non-metastatic triple-negative breast cancer and correlation with other biomarkers by Mansouri, Hanane, Alcaraz, Lindsay, Mollevi, Caroline, Mallavialle, Aude, Jacot, William, Boissière-Michot, Florence, Simony-Lafontaine, Joelle, Laurent-Matha, Valérie, Roger, Pascal, Liaudet-Coopman, Emmanuelle, Guiu, Séverine

“…Background: Microarrays studies identified the subtype of luminal androgen receptor (LAR) among triple-negative breast cancer (TNBC). This subgroup is distinct…”
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Latent TGF-β Activation Is a Hallmark of the Tenascin Family by Aubert, Alexandre, Mercier-Gouy, Perrine, Aguero, Stéphanie, Berthier, Laurent, Liot, Sophie, Prigent, Laura, Alcaraz, Lindsay, Verrier, Bernard, Terreux, Raphaël, Moali, Catherine, Lambert, Elise, Valcourt, Ulrich

“…Transforming growth factor-β (TGF-β) isoforms are secreted as inactive complexes formed through non-covalent interactions between bioactive TGF-β entities and…”
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Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-[Beta] by Alcaraz, Lindsay B, Exposito, Jean-Yves, Chuvin, Nicolas, Pommier, Roxane M, Cluzel, Caroline, Martel, Sylvie, Sentis, Stéphanie, Bartholin, Laurent, Lethias, Claire, Valcourt, Ulrich

“…Transforming growth factor β (TGF-β) isoforms are secreted as inactive complexes formed through noncovalent interactions between the bioactive TGF-β entity and…”
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TIF1 Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability by Pommier, Roxane M, Gout, Johann, Vincent, David, Alcaraz, Lindsay B, Chuvin, Nicolas, Arfi, Vanessa, Martel, Sylvie, Kaniewski, Bastien, Devailly, Guillaume, Fourel, Geneviève, Bernard, Pascal, Moyret-Lalle, Caroline, Ansieau, Stéphane, Puisieux, Alain, Valcourt, Ulrich, Sentis, Stéphanie, Bartholin, Laurent

“…The transcription accessory factor TIF1γ/TRIM33/RFG7/PTC7/Ectodermin functions as a tumor suppressor that promotes development and cellular differentiation…”
Get full text