Search Results - "Alcalde, Manuel"

The impaired quorum sensing response of Pseudomonas aeruginosa MexAB‐OprM efflux pump overexpressing mutants is not due to non‐physiological efflux of 3‐oxo‐C12‐HSL by Alcalde‐Rico, Manuel, Olivares‐Pacheco, Jorge, Halliday, Nigel, Cámara, Miguel, Martínez, José Luis

“…Summary Multidrug (MDR) efflux pumps are ancient and conserved molecular machineries with relevant roles in different aspects of the bacterial physiology,…”
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Discovery of inhibitors of Pseudomonas aeruginosa virulence through the search for natural‐like compounds with a dual role as inducers and substrates of efflux pumps by Laborda, Pablo, Alcalde‐Rico, Manuel, Chini, Andrea, Martínez, José L., Hernando‐Amado, Sara

“…Summary Multidrug efflux pumps are ancient elements encoded in every genome, from bacteria to humans. In bacteria, in addition to antibiotics, efflux pumps…”
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Multidrug Efflux Pumps at the Crossroad between Antibiotic Resistance and Bacterial Virulence by Alcalde-Rico, Manuel, Hernando-Amado, Sara, Blanco, Paula, Martínez, José L

“…Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different levels. Some efflux pumps are constitutively expressed at low levels…”
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A whole‐cell hypersensitive biosensor for beta‐lactams based on the AmpR‐AmpC regulatory circuit from the Antarctic Pseudomonas sp. IB20 by Higuera‐Llantén, Sebastián, Alcalde‐Rico, Manuel, Vasquez‐Ponce, Felipe, Ibacache‐Quiroga, Claudia, Blazquez, Jesús, Olivares‐Pacheco, Jorge

“…Detecting antibiotic residues is vital to minimize their impact. Yet, existing methods are complex and costly. Biosensors offer an alternative. While many…”
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Multidrug efflux pumps as main players in intrinsic and acquired resistance to antimicrobials by Hernando-Amado, Sara, Blanco, Paula, Alcalde-Rico, Manuel, Corona, Fernando, Reales-Calderón, Jose A, Sánchez, María B, Martínez, José L

“…Abstract Multidrug efflux pumps constitute a group of transporters that are ubiquitously found in any organism. In addition to other functions with relevance…”
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Metabolic Compensation of Fitness Costs Is a General Outcome for Antibiotic-Resistant Pseudomonas aeruginosa Mutants Overexpressing Efflux Pumps by Olivares Pacheco, Jorge, Alvarez-Ortega, Carolina, Alcalde Rico, Manuel, Martínez, José Luis

“…It is generally assumed that the acquisition of antibiotic resistance is associated with a fitness cost. We have shown that overexpression of the MexEF-OprN…”
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Role of the Multidrug Resistance Efflux Pump MexCD-OprJ in the Pseudomonas aeruginosa Quorum Sensing Response by Alcalde-Rico, Manuel, Olivares-Pacheco, Jorge, Alvarez-Ortega, Carolina, Cámara, Miguel, Martínez, José Luis

“…Multidrug efflux pumps constitute a category of antibiotic resistance determinants that are a part of the core bacterial genomes. Given their conservation, it…”
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Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants by Blanco, Paula, Hernando-Amado, Sara, Reales-Calderon, Jose Antonio, Corona, Fernando, Lira, Felipe, Alcalde-Rico, Manuel, Bernardini, Alejandra, Sanchez, Maria Blanca, Martinez, Jose Luis

“…Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all microorganisms. With few exceptions, they are chromosomally encoded and…”
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The MexJK Multidrug Efflux Pump Is Not Involved in Acquired or Intrinsic Antibiotic Resistance in Pseudomonas aeruginosa, but Modulates the Bacterial Quorum Sensing Response by Amieva, Rafael, Gil-Gil, Teresa, Martínez, José, Alcalde-Rico, Manuel

“…Multidrug efflux pumps are critical elements in both intrinsic and acquired antibiotic resistance of bacterial populations. Consequently, most studies…”
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Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance by Laborda, Pablo, Lolle, Signe, Hernando-Amado, Sara, Alcalde-Rico, Manuel, Aanæs, Kasper, Martínez, José Luis, Molin, Søren, Johansen, Helle Krogh

“…Mutations in mexZ , encoding a negative regulator of the expression of the mexXY efflux pump genes, are frequently acquired by Pseudomonas aeruginosa at early…”
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GIS-based study of the evolution of the IGN's strong motion network of mainland Spain and the balearics by José-Lázaro Amaro-Mellado, Daniel Antón, Juan-Manuel Alcalde

“…In some countries with seismicity, an adequate detection network is essential to assess seismic hazards. The Instituto Geográfico Nacional (National Geographic…”
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Muscle Tension Dysphonia: Which Laryngoscopic Features Can We Rely on for Diagnosis? by Garaycochea, Octavio, Navarrete, Juan Manuel Alcalde, del Río, Beatriz, Fernández, Secundino

“…Muscle tension dysphonia (MTD) is generally diagnosed through clinical history and physical examination. Several diagnostic or classification systems exist,…”
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Naringenin Inhibition of the Pseudomonas aeruginosa Quorum Sensing Response Is Based on Its Time-Dependent Competition With N -(3-Oxo-dodecanoyl)-L-homoserine Lactone for LasR Binding by Hernando-Amado, Sara, Alcalde-Rico, Manuel, Gil-Gil, Teresa, Valverde, José R, Martínez, José L

“…Bacterial quorum sensing (QS) is a cell-to-cell communication system that governs the expression of a large set of genes involved in bacterial-host…”
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Ceftazidime/avibactam resistance is associated with PER-3-producing ST309 lineage in Chilean clinical isolates of non-carbapenemase producing Pseudomonas aeruginosa by Soto, Katherine D, Alcalde-Rico, Manuel, Ugalde, Juan A, Olivares-Pacheco, Jorge, Quiroz, Valeria, Brito, Bárbara, Rivas, Lina M, Munita, José M, García, Patricia C, Wozniak, Aniela

“…Ceftazidime/avibactam (CZA) is indicated against multidrug-resistant , particularly those that are carbapenem resistant. CZA resistance in producing PER, a…”
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Acquisition of resistance to ceftazidime-avibactam during infection treatment in Pseudomonas aeruginosa through D179Y mutation in one of two blaKPC-2 gene copies without losing carbapenem resistance by García, Patricia, Brito, Bárbara, Alcalde-Rico, Manuel, Munita, José M., Martínez, Jose R. W., Olivares-Pacheco, Jorge, Quiroz, Valeria, Wozniak, Aniela

“…Ceftazidime/Avibactam (CAZ/AVI) is frequently used to treat KPC-producing Pseudomonas aeruginosa (KPC-PA) and Enterobacterales . CAZ/AVI resistance is driven…”
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Role of the multi-drug efflux systems on the baseline susceptibility to ceftazidime/avibactam and ceftolozane/tazobactam in clinical isolates of non-carbapenemase-producing carbapenem-resistant Pseudomonas aeruginosa by Contreras-Gómez, María José, Martinez, José R. W., Rivas, Lina, Riquelme-Neira, Roberto, Ugalde, Juan A., Wozniak, Aniela, García, Patricia, Munita, José M., Olivares-Pacheco, Jorge, Alcalde-Rico, Manuel

“…Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is one of the pathogens that urgently needs new drugs and new alternatives for its control. The primary…”
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Isolation of an Extensively Drug-Resistant Pseudomonas aeruginosa exoS + /O4 Strain Belonging to the "High-Risk" Clone ST654 and Coproducer of NDM-1 and the Novel VIM-80 by Opazo-Capurro, Andrés, Morales-León, Felipe, Jerez, Christian, Olivares-Pacheco, Jorge, Alcalde-Rico, Manuel, González-Muñoz, Paulina, Bello-Toledo, Helia, Cardenas-Arias, Adriana, Esposito, Fernanda, Lincopán, Nilton, Illesca, Vijna, González-Rocha, Gerardo

“…The aim of this study was to investigate the genomic features of an extensively drug-resistant (XDR) Pseudomonas aeruginosa isolate (P-469) emerging in Chile…”
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Dynamics of the MRSA Population in a Chilean Hospital: a Phylogenomic Analysis (2000-2016) by Martínez, José R W, Planet, Paul J, Spencer-Sandino, Maria, Rivas, Lina, Díaz, Lorena, Moustafa, Ahmed M, Quesille-Villalobos, Ana, Riquelme-Neira, Roberto, Alcalde-Rico, Manuel, Hanson, Blake, Carvajal, Lina P, Rincón, Sandra, Reyes, Jinnethe, Lam, Marusella, Calderon, Juan F, Araos, Rafael, García, Patricia, Arias, César A, Munita, José M

“…The global dissemination of methicillin-resistant Staphylococcus aureus (MRSA) is associated with the emergence and establishment of clones in specific…”
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Genetic characterization of clinically relevant class 1 integrons carried by multidrug resistant bacteria (MDRB) isolated from the gut microbiota of highly antibiotic treated Salmo salar by Vásquez-Ponce, Felipe, Higuera-Llantén, Sebastián, Parás-Silva, Juan, Gamboa-Acuña, Nicolás, Cortés, Jimena, Opazo-Capurro, Andrés, Ugalde, Juan A., Alcalde-Rico, Manuel, Olivares-Pacheco, Jorge

“…The main objective of this study was the genetic characterization of clinically relevant class 1 integrons carried by multidrug resistant bacteria isolated…”
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TORS as Part of Multilevel Surgery in OSA: The Importance of Careful Patient Selection and Outcomes by Baptista, Peter M, Diaz Zufiaurre, Natalia, Garaycochea, Octavio, Alcalde Navarrete, Juan Manuel, Moffa, Antonio, Giorgi, Lucrezia, Casale, Manuele, O'Connor-Reina, Carlos, Plaza, Guillermo

“…Transoral robotic surgery (TORS) for Obstructive Sleep Apnea (OSA) is a relatively young technique principally devised for managing apneas in the tongue base…”
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