Search Results - "Alcalay, Roy N"

Precision medicine in Parkinson’s disease: emerging treatments for genetic Parkinson’s disease by Schneider, Susanne A., Alcalay, Roy N.

“…In recent years, numerous clinical trials for disease modification in Parkinson’s disease (PD) have failed, possibly because of a “one-size-fits all” approach…”
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Impact of the COVID‐19 Pandemic on Parkinson's Disease and Movement Disorders by Papa, Stella M., Brundin, Patrik, Fung, Victor S.C., Kang, Un Jung, Burn, David J., Colosimo, Carlo, Chiang, Han‐Lin, Alcalay, Roy N., Trenkwalder, Claudia

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Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease by Fraser, Kyle B., Rawlins, Ashlee B., Clark, Rachel G., Alcalay, Roy N., Standaert, David G., Liu, Nianjun, West, Andrew B.

“…ABSTRACT Background Mutations in Leucine‐rich repeat kinase 2 (LRRK2) enhance levels of the autophosphorylated LRRK2 protein and are the most common known…”
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The neuropathology of genetic Parkinson's disease by Poulopoulos, Markos, Levy, Oren A., Alcalay, Roy N.

“…Pathological data from autopsies genotyped for Parkinson's disease (PD)‐related mutations in alpha‐synuclein, Parkin, PINK1, DJ1, LRRK2, and glucocerebrosidase…”
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Urinary proteome profiling for stratifying patients with familial Parkinson’s disease by Virreira Winter, Sebastian, Karayel, Ozge, Strauss, Maximilian T, Padmanabhan, Shalini, Surface, Matthew, Merchant, Kalpana, Alcalay, Roy N, Mann, Matthias

“…The prevalence of Parkinson's disease (PD) is increasing but the development of novel treatment strategies and therapeutics altering the course of the disease…”
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Cerebrospinal fluid, plasma, and saliva in the BioFIND study: Relationships among biomarkers and Parkinson's disease Features by Goldman, Jennifer G., Andrews, Howard, Amara, Amy, Naito, Anna, Alcalay, Roy N., Shaw, Leslie M., Taylor, Peggy, Xie, Tao, Tuite, Paul, Henchcliffe, Claire, Hogarth, Penelope, Frank, Samuel, Saint‐Hilaire, Marie‐Helene, Frasier, Mark, Arnedo, Vanessa, Reimer, Alyssa N., Sutherland, Margaret, Swanson‐Fischer, Christine, Gwinn, Katrina, Kang, Un Jung

“…ABSTRACT Objective: Examine relationships among neurodegenerative biomarkers and PD motor and nonmotor symptoms. Background: CSF alpha‐synuclein is decreased…”
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Higher Urine bis(Monoacylglycerol)Phosphate Levels in LRRK2 G2019S Mutation Carriers: Implications for Therapeutic Development by Alcalay, Roy N., Hsieh, Frank, Tengstrand, Elizabeth, Padmanabhan, Shalini, Baptista, Marco, Kehoe, Caitlin, Narayan, Sushma, Boehme, Amelia K., Merchant, Kalpana

“…Background LRRK2 mutations are a common cause of dominantly inherited PD. Previous studies showed decreases in urine levels of didocohexaenoyl (22:6)…”
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Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis by Chan, Robin B, Perotte, Adler J, Zhou, Bowen, Liong, Christopher, Shorr, Evan J, Marder, Karen S, Kang, Un J, Waters, Cheryl H, Levy, Oren A, Xu, Yimeng, Shim, Hong Bin, Pe'er, Itsik, Di Paolo, Gilbert, Alcalay, Roy N

“…Parkinson's disease (PD) is a common neurodegenerative disease whose pathological hallmark is the accumulation of intracellular α-synuclein aggregates in Lewy…”
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Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non‐Ashkenazi Jewish ancestry by Lee, Annie J., Wang, Yuanjia, Alcalay, Roy N., Mejia‐Santana, Helen, Saunders‐Pullman, Rachel, Bressman, Susan, Corvol, Jean‐Christophe, Brice, Alexis, Lesage, Suzanne, Mangone, Graziella, Tolosa, Eduardo, Pont‐Sunyer, Claustre, Vilas, Dolores, Schüle, Birgitt, Kausar, Farah, Foroud, Tatiana, Berg, Daniela, Brockmann, Kathrin, Goldwurm, Stefano, Siri, Chiara, Asselta, Rosanna, Ruiz‐Martinez, Javier, Mondragón, Elisabet, Marras, Connie, Ghate, Taneera, Giladi, Nir, Mirelman, Anat, Marder, Karen

“…ABSTRACT Background Penetrance estimates of the leucine‐rich repeat kinase 2 (LRRK2) p.G2019S mutation for PD vary widely (24%‐100%). The p.G2019S penetrance…”
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Targeted sequencing of Parkinson's disease loci genes highlights SYT11, FGF20 and other associations by Rudakou, Uladzislau, Yu, Eric, Krohn, Lynne, Ruskey, Jennifer A, Asayesh, Farnaz, Dauvilliers, Yves, Spiegelman, Dan, Greenbaum, Lior, Fahn, Stanley, Waters, Cheryl H, Dupré, Nicolas, Rouleau, Guy A, Hassin-Baer, Sharon, Fon, Edward A, Alcalay, Roy N, Gan-Or, Ziv

“…Genome-wide association studies (GWAS) have identified numerous loci associated with Parkinson's disease. The specific genes and variants that drive the…”
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Cerebrospinal fluid proteomics implicates the granin family in Parkinson’s disease by Rotunno, Melissa S., Lane, Monica, Zhang, Wenfei, Wolf, Pavlina, Oliva, Petra, Viel, Catherine, Wills, Anne-Marie, Alcalay, Roy N., Scherzer, Clemens R., Shihabuddin, Lamya S., Zhang, Kate, Sardi, S. Pablo

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Better understanding of…”
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The association between Mediterranean diet adherence and Parkinson's disease by Alcalay, Roy N., Gu, Yian, Mejia-Santana, Helen, Cote, Lucien, Marder, Karen S., Scarmeas, Nikolaos

“…Background: Recent studies have demonstrated an association between a Mediterranean‐type diet and Alzheimer's risk. We assessed the association between…”
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Arm swing as a potential new prodromal marker of Parkinson's disease by Mirelman, Anat, Bernad-Elazari, Hagar, Thaler, Avner, Giladi-Yacobi, Eytan, Gurevich, Tanya, Gana-Weisz, Mali, Saunders-Pullman, Rachel, Raymond, Deborah, Doan, Nancy, Bressman, Susan B., Marder, Karen S., Alcalay, Roy N., Rao, Ashwini K., Berg, Daniela, Brockmann, Kathrin, Aasly, Jan, Waro, Bjørg Johanne, Tolosa, Eduardo, Vilas, Dolores, Pont-Sunyer, Claustre, Orr-Urtreger, Avi, Hausdorff, Jeffrey M., Giladi, Nir

“…ABSTRACT Background Reduced arm swing is a well‐known clinical feature of Parkinson's disease (PD), often observed early in the course of the disease. We…”
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Patterns of TDP‐43 Deposition in Brains with LRRK2 G2019S Mutations by Agin‐Liebes, Julian, Hickman, Richard A., Vonsattel, Jean Paul, Faust, Phyllis L., Flowers, Xena, Utkina Sosunova, Irina, Ntiri, Joel, Mayeux, Richard, Surface, Matthew, Marder, Karen, Fahn, Stanley, Przedborski, Serge, Alcalay, Roy N.

“…Objective To assess for TDP‐43 deposits in brains with and without a LRRK2 G2019S mutation. Background LRRK2 G2019S mutations have been associated with…”
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Subnormal GM1 in PBMCs: Promise for Early Diagnosis of Parkinson's Disease? by Alselehdar, Samar K, Chakraborty, Monami, Chowdhury, Suman, Alcalay, Roy N, Surface, Matthew, Ledeen, Robert

“…The fact that Parkinson's disease (PD) pathologies are well advanced in most PD patients by the time of clinical elucidation attests to the importance of early…”
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Analysis of Heterozygous PRKN Variants and Copy‐Number Variations in Parkinson's Disease by Yu, Eric, Rudakou, Uladzislau, Krohn, Lynne, Mufti, Kheireddin, Ruskey, Jennifer A., Asayesh, Farnaz, Estiar, Mehrdad A., Spiegelman, Dan, Surface, Matthew, Fahn, Stanley, Waters, Cheryl H., Greenbaum, Lior, Espay, Alberto J., Dauvilliers, Yves, Dupré, Nicolas, Rouleau, Guy A., Hassin‐Baer, Sharon, Fon, Edward A., Alcalay, Roy N., Gan‐Or, Ziv

“…ABSTRACT Background Biallelic PRKN mutation carriers with Parkinson's disease (PD) typically have an earlier disease onset, slow disease progression, and,…”
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The impact of COVID-19 and social distancing on people with Parkinson’s disease: a survey study by Feeney, Megan P., Xu, Yaqian, Surface, Matthew, Shah, Hiral, Vanegas-Arroyave, Nora, Chan, Amanda K., Delaney, Elizabeth, Przedborski, Serge, Beck, James C., Alcalay, Roy N.

“…As the COVID-19 pandemic continues to affect the international community, very little is known about its impact on the health and day-to-day activities of…”
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Sequencing of the GBA coactivator, Saposin C, in Parkinson disease by Ouled Amar Bencheikh, Bouchra, Leveille, Etienne, Ruskey, Jennifer A., Spiegelman, Dan, Liong, Christopher, Fon, Edward A., Rouleau, Guy A., Dauvilliers, Yves, Dupre, Nicolas, Alcalay, Roy N., Gan-Or, Ziv

“…Saposin C (SapC), encoded by PSAP, is required for the activity of glucocerebrosidase, encoded by GBA. Although GBA mutations have been studied thoroughly in…”
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Clinical and neuropathological features of progressive supranuclear palsy in Leucine rich repeat kinase (LRRK2) G2019S mutation carriers by Vilas, Dolores, Sharp, Madeleine, Gelpi, Ellen, Genís, David, Marder, Karen S., Cortes, Etty, Vonsattel, Jean‐Paul, Tolosa, Eduard, Alcalay, Roy N.

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Toward a biomarker panel measured in CNS-originating extracellular vesicles for improved differential diagnosis of Parkinson's disease and multiple system atrophy by Taha, Hash Brown, Hornung, Simon, Dutta, Suman, Fenwick, Leony, Lahgui, Otmane, Howe, Kathryn, Elabed, Nour, Del Rosario, Irish, Wong, Darice Y, Duarte Folle, Aline, Markovic, Daniela, Palma, Jose-Alberto, Kang, Un Jung, Alcalay, Roy N, Sklerov, Miriam, Kaufmann, Horacio, Fogel, Brent L, Bronstein, Jeff M, Ritz, Beate, Bitan, Gal

“…[...]the oEV concentrations of pS129-α-syn increased in the same order, HC < PD < MSA, and were significantly higher in both disease groups (Fig. 1a)…”
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