Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions

Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions

Leptin is a hormone derived from adipose tissue and the small intestine, mainly in enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in decreased fat mass in adipocytes. Leptin has specific receptors in the ventromedial and arcuate nuclei and other parts of the hypot...

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Bibliographic Details
Published in:Journal of medicine and life Vol. 14; no. 5; pp. 600 - 605
Main Authors: Al-Hussaniy, Hany Akeel, Alburghaif, Ali Hikmate, Naji, Meena Akeel
Format: Journal Article
Language:English
Published: Romania Carol Daila University Foundation 01-09-2021
Carol Davila University Press
Subjects:
Appetite
Autoimmune diseases
Body fat
Breast cancer
Cancer therapies
Cell cycle
Colorectal cancer
Cytokines
Diabetes
Diabetes Mellitus
Energy
Energy Metabolism
Female
Fertility
Gene expression
Growth hormones
Humans
Hypothalamus
Hypothalamus - metabolism
Immune system
Leptin
Lymphocytes
Metabolism
Obesity
Ovaries
Polycystic ovary syndrome
Receptors, Leptin
Reproduction
Review
Tumor necrosis factor-TNF
Tumors
leptin analog
Metreleptin
endocrine hormone
leptin mutations
reproduction
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Summary:Leptin is a hormone derived from adipose tissue and the small intestine, mainly in enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in decreased fat mass in adipocytes. Leptin has specific receptors in the ventromedial and arcuate nuclei and other parts of the hypothalamus and the feeding center in the ventral tegmental area. It also plays a role in regulatory aspects other than fat cells, such as obesity, which is linked to a loss of sensitivity of leptin receptors, resulting in an inability to produce satiety and an increase in food intake. Moreover, leptin plays a part in lactation, bone density, the immune system, diabetes treatments, and hypertriglyceridemia. The latest studies in leptin suggest that an analog of leptin may treat DM and hypertriglyceridemia. Further research should be conducted on the effectiveness of leptin on other related diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1844-122X
1844-3117
DOI:10.25122/jml-2021-0153