Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities

This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive activity of their constituents. This bibliogr...

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Bibliographic Details
Published in:	Pharmaceutics Vol. 12; no. 10; p. 933
Main Authors:	Oliveira, Verônica da Silva, de Almeida, Amanda Silva, Albuquerque, Ingrid da Silva, Duarte, Fernanda Ílary Costa, Queiroz, Bárbara Cristina Silva Holanda, Converti, Attilio, Lima, Ádley Antonini Neves de
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 30-09-2020 MDPI
Subjects:	Bioavailability biological applications Breast cancer Cytotoxicity drug delivery Drug dosages Polyethylene glycol Polymers Review solid dispersions Surfactants
Online Access:	Get full text
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Summary:	This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive activity of their constituents. This bibliographic survey shows that the development of solid dispersions provides benefits in the physicochemical properties of bioactive compounds, which lead to an increase in their biological potential. However, despite the reports found on solid dispersions, there is still a need for biological assay-based studies, mainly in vivo, to assist in the investigation and to devise new applications. Therefore, studies based on such an approach are of great importance to enhance and extend the use of solid dispersions in the most diverse therapeutic applications.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1999-4923 1999-4923
DOI:	10.3390/pharmaceutics12100933