Search Results - "Albrecht, Steffen"

Whose voice is heard in online deliberation?: A study of participation and representation in political debates on the internet by Albrecht, Steffen

“…One of the core elements of the vision of 'electronic democracy' is the hope that the Internet permits free and equal access to political debates. However,…”
Get full text

Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency by Bouffet, Eric, Larouche, Valérie, Campbell, Brittany B, Merico, Daniele, de Borja, Richard, Aronson, Melyssa, Durno, Carol, Krueger, Joerg, Cabric, Vanja, Ramaswamy, Vijay, Zhukova, Nataliya, Mason, Gary, Farah, Roula, Afzal, Samina, Yalon, Michal, Rechavi, Gideon, Magimairajan, Vanan, Walsh, Michael F, Constantini, Shlomi, Dvir, Rina, Elhasid, Ronit, Reddy, Alyssa, Osborn, Michael, Sullivan, Michael, Hansford, Jordan, Dodgshun, Andrew, Klauber-Demore, Nancy, Peterson, Lindsay, Patel, Sunil, Lindhorst, Scott, Atkinson, Jeffrey, Cohen, Zane, Laframboise, Rachel, Dirks, Peter, Taylor, Michael, Malkin, David, Albrecht, Steffen, Dudley, Roy W R, Jabado, Nada, Hawkins, Cynthia E, Shlien, Adam, Tabori, Uri

“…Recurrent glioblastoma multiforme (GBM) is incurable with current therapies. Biallelic mismatch repair deficiency (bMMRD) is a highly penetrant childhood…”
Get full text

Meeting report: “Generative artificial intelligence – Opportunities, risks and policy challenges”. EPTA Conference, 2023, Barcelona, ES by Albrecht, Steffen, Grünwald, Reinhard

Get full text

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas by Khuong-Quang, Dong-Anh, Buczkowicz, Pawel, Rakopoulos, Patricia, Liu, Xiao-Yang, Fontebasso, Adam M., Bouffet, Eric, Bartels, Ute, Albrecht, Steffen, Schwartzentruber, Jeremy, Letourneau, Louis, Bourgey, Mathieu, Bourque, Guillaume, Montpetit, Alexandre, Bourret, Genevieve, Lepage, Pierre, Fleming, Adam, Lichter, Peter, Kool, Marcel, von Deimling, Andreas, Sturm, Dominik, Korshunov, Andrey, Faury, Damien, Jones, David T., Majewski, Jacek, Pfister, Stefan M., Jabado, Nada, Hawkins, Cynthia

“…Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated…”
Get full text

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations by Liu, Xiao-Yang, Gerges, Noha, Korshunov, Andrey, Sabha, Nesrin, Khuong-Quang, Dong-Anh, Fontebasso, Adam M., Fleming, Adam, Hadjadj, Djihad, Schwartzentruber, Jeremy, Majewski, Jacek, Dong, Zhifeng, Siegel, Peter, Albrecht, Steffen, Croul, Sidney, Jones, David TW, Kool, Marcel, Tonjes, Martje, Reifenberger, Guido, Faury, Damien, Zadeh, Gelareh, Pfister, Stefan, Jabado, Nada

“…Gliomas are the most common primary brain tumors in children and adults. We recently identified frequent alterations in chromatin remodelling pathways…”
Get full text

Single-cell specific and interpretable machine learning models for sparse scChIP-seq data imputation by Albrecht, Steffen, Andreani, Tommaso, Andrade-Navarro, Miguel A, Fontaine, Jean Fred

“…Single-cell Chromatin ImmunoPrecipitation DNA-Sequencing (scChIP-seq) analysis is challenging due to data sparsity. High degree of sparsity in biological…”
Get full text

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas by Fontebasso, Adam M., Schwartzentruber, Jeremy, Khuong-Quang, Dong-Anh, Liu, Xiao-Yang, Sturm, Dominik, Korshunov, Andrey, Jones, David T. W., Witt, Hendrik, Kool, Marcel, Albrecht, Steffen, Fleming, Adam, Hadjadj, Djihad, Busche, Stephan, Lepage, Pierre, Montpetit, Alexandre, Staffa, Alfredo, Gerges, Noha, Zakrzewska, Magdalena, Zakrzewski, Krzystof, Liberski, Pawel P., Hauser, Peter, Garami, Miklos, Klekner, Almos, Bognar, Laszlo, Zadeh, Gelareh, Faury, Damien, Pfister, Stefan M., Jabado, Nada, Majewski, Jacek

“…Recurrent mutations affecting the histone H3.3 residues Lys27 or indirectly Lys36 are frequent drivers of pediatric high-grade gliomas (over 30 % of HGGs). To…”
Get full text

seqQscorer: automated quality control of next-generation sequencing data using machine learning by Albrecht, Steffen, Sprang, Maximilian, Andrade-Navarro, Miguel A, Fontaine, Jean-Fred

“…Controlling quality of next-generation sequencing (NGS) data files is a necessary but complex task. To address this problem, we statistically characterize…”
Get full text

Germ-line and somatic DICER1 mutations in pineoblastoma by de Kock, Leanne, Sabbaghian, Nelly, Druker, Harriet, Weber, Evan, Hamel, Nancy, Miller, Suzanne, Choong, Catherine S., Gottardo, Nicholas G., Kees, Ursula R., Rednam, Surya P., van Hest, Liselotte P., Jongmans, Marjolijn C., Jhangiani, Shalini, Lupski, James R., Zacharin, Margaret, Bouron-Dal Soglio, Dorothée, Huang, Annie, Priest, John R., Perry, Arie, Mueller, Sabine, Albrecht, Steffen, Malkin, David, Grundy, Richard G., Foulkes, William D.

“…Germ-line RB - 1 mutations predispose to pineoblastoma (PinB), but other predisposing genetic factors are not well established. We recently identified a…”
Get full text

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct by Northcott, Paul A., Hielscher, Thomas, Dubuc, Adrian, Mack, Stephen, Shih, David, Remke, Marc, Al-Halabi, Hani, Albrecht, Steffen, Jabado, Nada, Eberhart, Charles G., Grajkowska, Wieslawa, Weiss, William A., Clifford, Steven C., Bouffet, Eric, Rutka, James T., Korshunov, Andrey, Pfister, Stefan, Taylor, Michael D.

“…Recent integrative genomic approaches have defined molecular subgroups of medulloblastoma that are genetically and clinically distinct. Sonic hedgehog (Shh)…”
Get full text

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas by Bechet, Denise, Gielen, Gerrit G. H., Korshunov, Andrey, Pfister, Stefan M., Rousso, Caterina, Faury, Damien, Fiset, Pierre-Olivier, Benlimane, Naciba, Lewis, Peter W., Lu, Chao, David Allis, C., Kieran, Mark W., Ligon, Keith L., Pietsch, Torsten, Ellezam, Benjamin, Albrecht, Steffen, Jabado, Nada

“…Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in…”
Get full text

A Recurrent PDGFRB Mutation Causes Familial Infantile Myofibromatosis by Cheung, Yee Him, Gayden, Tenzin, Campeau, Philippe M., LeDuc, Charles A., Russo, Donna, Nguyen, Van-Hung, Guo, Jiancheng, Qi, Ming, Guan, Yanfang, Albrecht, Steffen, Moroz, Brenda, Eldin, Karen W., Lu, James T., Schwartzentruber, Jeremy, Malkin, David, Berghuis, Albert M., Emil, Sherif, Gibbs, Richard A., Burk, David L., Vanstone, Megan, Lee, Brendan H., Orchard, David, Boycott, Kym M., Chung, Wendy K., Jabado, Nada

“…Infantile myofibromatosis (IM) is the most common benign fibrous tumor of soft tissues affecting young children. By using whole-exome sequencing, RNA…”
Get full text

Case Report: Aperiodic Fluctuations of Neural Activity in the Ictal MEG of a Child With Drug-Resistant Fronto-Temporal Epilepsy by van Heumen, Saskia, Moreau, Jeremy T, Simard-Tremblay, Elisabeth, Albrecht, Steffen, Dudley, Roy Wr, Baillet, Sylvain

“…Successful surgical treatment of patients with focal drug-resistant epilepsy remains challenging, especially in cases for which it is difficult to define the…”
Get full text

Preclinical Evaluation of Radiation and Perifosine in a Genetically and Histologically Accurate Model of Brainstem Glioma by BECHER, Oren J, HAMBARDZUMYAN, Dolores, MACDONALD, Tobey J, HOLLAND, Eric C, WALKER, Talia R, HELMY, Karim, NAZARIAN, Javad, ALBRECHT, Steffen, HINER, Rebecca L, GALL, Sarah, HUSE, Jason T, JABADO, Nada

“…Brainstem gliomas (BSG) are a rare group of central nervous system tumors that arise mostly in children and usually portend a particularly poor prognosis. We…”
Get full text

Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas by JACOB, Karine, QUANG-KHUONG, Dongh-Anh, GARAMI, Miklos, HAUSER, Peter, KLEKNER, Almos, BOGNAR, Laszlo, FARMER, Jean-Pierre, MONTES, Jose-Luis, ATKINSON, Jeffrey, HAWKINS, Cynthia, KORSHUNOV, Andrey, COLLINS, V. Peter, JONES, David T. W, PFISTER, Stefan M, TABORI, Uri, JABADO, Nada, WITT, Hendrik, LAMBERT, Sally, ALBRECHT, Steffen, WITT, Olaf, VEZINA, Catherine, SHIRINIAN, Margret, FAURY, Damien

“…Oncogenic BRAF/Ras or NF1 loss can potentially trigger oncogene-induced senescence (OIS) through activation of the mitogen-activated protein kinase (MAPK)…”
Get full text

Forecasting severe respiratory disease hospitalizations using machine learning algorithms by Albrecht, Steffen, Broderick, David, Dost, Katharina, Cheung, Isabella, Nghiem, Nhung, Wu, Milton, Zhu, Johnny, Poonawala-Lohani, Nooriyan, Jamison, Sarah, Rasanathan, Damayanthi, Huang, Sue, Trenholme, Adrian, Stanley, Alicia, Lawrence, Shirley, Marsh, Samantha, Castelino, Lorraine, Paynter, Janine, Turner, Nikki, McIntyre, Peter, Riddle, Patricia, Grant, Cameron, Dobbie, Gillian, Wicker, Jörg Simon

“…Forecasting models predicting trends in hospitalization rates have the potential to inform hospital management during seasonal epidemics of respiratory…”
Get full text

The utility of arterial spin labeling in the presurgical evaluation of poorly defined focal epilepsy in children by Lam, Jack, Tomaszewski, Patricia, Gilbert, Guillaume, Moreau, Jeremy T, Guiot, Marie-Christine, Albrecht, Steffen, Farmer, Jean-Pierre, Atkinson, Jeffrey, Saint-Martin, Christine, Wintermark, Pia, Bernhardt, Boris, Baillet, Sylvain, Dudley, Roy W R

“…The authors sought to assess the utility of arterial spin labeling (ASL) perfusion 3T-MRI for the presurgical evaluation of poorly defined focal epilepsy in…”
Get full text

Unexpected allelic heterogeneity and spectrum of mutations in Fowler syndrome revealed by next-generation exome sequencing by Lalonde, Emilie, Albrecht, Steffen, Ha, Kevin C.H, Jacob, Karine, Bolduc, Nathalie, Polychronakos, Constantin, Dechelotte, Pierre, Majewski, Jacek, Jabado, Nada

“…Protein coding genes constitute approximately 1% of the human genome but harbor 85% of the mutations with large effects on disease-related traits. Therefore,…”
Get full text

Active Caspase-6 and Caspase-6-Cleaved Tau in Neuropil Threads, Neuritic Plaques, and Neurofibrillary Tangles of Alzheimer's Disease by Guo, Huishan, Albrecht, Steffen, Bourdeau, Martine, Petzke, Tracy, Bergeron, Catherine, LeBlanc, Andrea C.

“…Previously, we have shown that caspase-6 but not caspase-3 is activated by serum deprivation and induces a protracted cell death in primary cultures of human…”
Get full text

Expression and activation of caspase-6 in human fetal and adult tissues by Godefroy, Nelly, Foveau, Bénédicte, Albrecht, Steffen, Goodyer, Cynthia G, LeBlanc, Andréa C

“…Caspase-6 is an effector caspase that has not been investigated thoroughly despite the fact that Caspase-6 is strongly activated in Alzheimer disease brains…”
Get full text