Search Results - "Albrecht, Simone"

A comparative study of free oligosaccharides in the milk of domestic animals by Albrecht, Simone, Lane, Jonathan A., Mariño, Karina, Al Busadah, Khalid A., Carrington, Stephen D., Hickey, Rita M., Rudd, Pauline M.

“…The present study was conducted to obtain a comprehensive overview of oligosaccharides present in the milk of a variety of important domestic animals including…”
Get full text

The Promoter of the Immune-Modulating Gene TIR-Containing Protein C of the Uropathogenic Escherichia coli Strain CFT073 Reacts to the Pathogen's Environment by Hemberger, Jacqueline, Ittensohn, Julia, Griffiths, Hannah, Keller, Maren, Costina, Victor, Albrecht, Simone, Miethke, Thomas

“…The (TcpC) of the uropathogenic strain CFT073 modulates innate immunity by interfering with the Toll-like receptor and NALP3 inflammasome signaling cascade…”
Get full text

Proteomics in biomanufacturing control: Protein dynamics of CHO‐K1 cells and conditioned media during apoptosis and necrosis by Albrecht, Simone, Kaisermayer, Christian, Gallagher, Clair, Farrell, Amy, Lindeberg, Anna, Bones, Jonathan

“…Cell viability has a critical impact on product quantity and quality during the biomanufacturing of therapeutic proteins. An advanced understanding of changes…”
Get full text

In Vivo Mapping of Hydrogen Peroxide and Oxidized Glutathione Reveals Chemical and Regional Specificity of Redox Homeostasis by Albrecht, Simone C., Barata, Ana Gomes, Großhans, Jörg, Teleman, Aurelio A., Dick, Tobias P.

“…The glutathione redox couple (GSH/GSSG) and hydrogen peroxide (H2O2) are central to redox homeostasis and redox signaling, yet their distribution within an…”
Get full text

Comprehensive Profiling of Glycosphingolipid Glycans Using a Novel Broad Specificity Endoglycoceramidase in a High-Throughput Workflow by Albrecht, Simone, Vainauskas, Saulius, Stöckmann, Henning, McManus, Ciara, Taron, Christopher H, Rudd, Pauline M

“…The biological function of glycosphingolipids (GSLs) is largely determined by their glycan headgroup moiety. This has placed a renewed emphasis on detailed GSL…”
Get full text

Absolute Configuration of Rhizopodin and Its Inhibition of Actin Polymerization by Dimerization by Hagelueken, Gregor, Albrecht, Simone C, Steinmetz, Heinrich, Jansen, Rolf, Heinz, Dirk W, Kalesse, Markus, Schubert, Wolf-Dieter

“…Three's company: Rhizopodin is a cytostatic macrolide and a potent actin depolymerizer produced by the myxobacterium Myxococcus stipitatus. A crystal structure…”
Get full text

Redesign of genetically encoded biosensors for monitoring mitochondrial redox status in a broad range of model eukaryotes by Albrecht, Simone C, Sobotta, Mirko C, Bausewein, Daniela, Aller, Isabel, Hell, Rüdiger, Dick, Tobias P, Meyer, Andreas J

“…The development of genetically encoded redox biosensors has paved the way toward chemically specific, quantitative, dynamic, and compartment-specific redox…”
Get more information

Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines by Mimura, Yusuke, Kelly, Ronan M., Unwin, Louise, Albrecht, Simone, Jefferis, Roy, Goodall, Margaret, Mizukami, Yoichi, Mimura-Kimura, Yuka, Matsumoto, Tsuneo, Ueoka, Hiroshi, Rudd, Pauline M.

“…Glycosylation of the IgG-Fc is essential for optimal binding and activation of Fcγ receptors and the C1q component of complement. However, it has been reported…”
Get full text

Glycosylation as a marker for inflammatory arthritis by Albrecht, Simone, Unwin, Louise, Muniyappa, Mohankumar, Rudd, Pauline M

“…Changes in serum protein glycosylation play an important role in inflammatory arthritis. Altered galactosylation of immunoglobulin G (IgG) in rheumatoid…”
Get more information

Regulation of Expression of the TIR-Containing Protein C Gene of the Uropathogenic Escherichia coli Strain CFT073 by Ittensohn, Julia, Hemberger, Jacqueline, Griffiths, Hannah, Keller, Maren, Albrecht, Simone, Miethke, Thomas

“…The uropathogenic Escherichia coli strain CFT073 causes kidney abscesses in mice Toll/interleukin-1 receptor domain-containing protein C (TcpC) dependently and…”
Get full text

Pregnancy-Associated Changes of IgG and Serum N‑Glycosylation in Camel (Camelus dromedarius) by Adamczyk, Barbara, Albrecht, Simone, Stöckmann, Henning, Ghoneim, Ibrahim M, Al-Eknah, Marzook, Al-Busadah, Khalid A. S, Karlsson, Niclas G, Carrington, Stephen D, Rudd, Pauline M

“…The dromedary camel (Camelus dromedarius) is an agriculturally important species of high economic value but of low reproductive efficiency. Serum and IgG…”
Get full text

Isolation and structure revision of the actin-binding macrolide rhizopodin from Myxococcus stipitatus (Myxobacteria) by Jansen, Rolf, Steinmetz, Heinrich, Sasse, Florenz, Schubert, Wolf-Dieter, Hagelüken, Gregor, Albrecht, Simone C., Müller, Rolf

“…Rhizopodin was isolated as cytostatic and weakly antifungal macrolide ( 1) and later characterized as potent actin-depolymerizing agent. It is produced by the…”
Get full text

Examining the sources of variability in cell culture media used for biopharmaceutical production by McGillicuddy, Nicola, Floris, Patrick, Albrecht, Simone, Bones, Jonathan

“…Raw materials, in particular cell culture media, represent a significant source of variability to biopharmaceutical manufacturing processes that can…”
Get full text

Glycosylation Analysis of Therapeutic Glycoproteins Produced in CHO Cells by Carillo, Sara, Mittermayr, Stefan, Farrell, Amy, Albrecht, Simone, Bones, Jonathan

“…In the last decades, the number of approved therapeutic proteins drugs is increasing exponentially and a large number of new therapeutic entities are…”
Get more information

Untargeted LC-MS/MS Profiling of Cell Culture Media Formulations for Evaluation of High Temperature Short Time Treatment Effects by Floris, Patrick, McGillicuddy, Nicola, Albrecht, Simone, Morrissey, Brian, Kaisermayer, Christian, Lindeberg, Anna, Bones, Jonathan

“…An untargeted LC-MS/MS platform was implemented for monitoring variations in CHO cell culture media upon exposure to high temperature short time (HTST)…”
Get full text

CHOmpact: A reduced metabolic model of Chinese hamster ovary cells with enhanced interpretability by Jiménez del Val, Ioscani, Kyriakopoulos, Sarantos, Albrecht, Simone, Stockmann, Henning, Rudd, Pauline M., Polizzi, Karen M., Kontoravdi, Cleo

“…Metabolic modeling has emerged as a key tool for the characterization of biopharmaceutical cell culture processes. Metabolic models have also been instrumental…”
Get full text

Multiple reaction monitoring targeted LC-MS analysis of potential cell death marker proteins for increased bioprocess control by Albrecht, Simone, Kaisermayer, Christian, Reinhart, David, Ambrose, Monica, Kunert, Renate, Lindeberg, Anna, Bones, Jonathan

“…The monitoring of protein biomarkers for the early prediction of cell stress and death is a valuable tool for process characterization and efficient…”
Get full text

Human milk composition differs in healthy mothers and mothers with celiac disease by Olivares, Marta, Albrecht, Simone, De Palma, Giada, Ferrer, María Desamparados, Castillejo, Gemma, Schols, Henk A, Sanz, Yolanda

“…PURPOSE: To investigate whether breast-milk composition and microbiota differ in healthy mothers and mothers with celiac disease (CD) to ultimately contribute…”
Get full text

Twoplex 12/13 C6 aniline stable isotope and linkage-specific sialic acid labeling 2D-LC-MS workflow for quantitative N-glycomics by Albrecht, Simone, Mittermayr, Stefan, Smith, Josh, Martín, Silvia Millán, Doherty, Margaret, Bones, Jonathan

“…Quantitative glycomics represents an actively expanding research field ranging from the discovery of disease-associated glycan alterations to the quantitative…”
Get full text

A LC–MS/MS platform for the identification of productivity markers in industrial mammalian cell culture media by Floris, Patrick, McGillicuddy, Nicola, Morrissey, Brian, Albrecht, Simone, Kaisermayer, Christian, Hawe, David, Riordan, Lelia, Lindeberg, Anna, Forestell, Sean, Bones, Jonathan

“…[Display omitted] •Untargeted LC–MS/MS analysis of cell culture media resulted in the quantification of >2500 features.•Multivariate data analysis highlighted…”
Get full text