Search Results - "Alboreggia, Giulia"

Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist by Udompholkul, Parima, Garza-Granados, Ana, Alboreggia, Giulia, Baggio, Carlo, McGuire, Jack, Pegan, Scott D., Pellecchia, Maurizio

“…We have recently reported on the use of aryl-fluorosulfates in designing water- and plasma-stable agents that covalently target Lys, Tyr, or His residues in…”
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Conformational switch and multiple supramolecular structures of a newly identified self-assembling protein-mimetic peptide from Pseudomonas aeruginosa YeaZ protein by Fasola, Elettra, Alboreggia, Giulia, Pieraccini, Stefano, Oliva, Francesco, Agharbaoui, Fatima Ezzahra, Bollati, Michela, Bertoni, Giovanni, Recchia, Sandro, Marelli, Marcello, Piarulli, Umberto, Pellegrino, Sara, Gazzola, Silvia

“…Protein-mimetic peptides (PMPs) are shorter sequences of self-assembling proteins, that represent remarkable building blocks for the generation of bioinspired…”
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Targeted degradation of Pin1 by protein-destabilizing compounds by Alboreggia, Giulia, Udompholkul, Parima, Rodriguez, Isaac, Blaha, Gregor, Pellecchia, Maurizio

“…The concept of targeted protein degradation is at the forefront of modern drug discovery, which aims to eliminate disease-causing proteins using specific…”
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Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein by Udompholkul, Parima, Baggio, Carlo, Gambini, Luca, Alboreggia, Giulia, Pellecchia, Maurizio

“…We have recently reported on Lys-covalent agents that, based on aryl-sulfonyl fluorides, were designed to target binding site Lys 311 in the X-linked inhibitor…”
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Abstract 2460 Structure Studies of Suicide Inhibitors Bound to Human Pin1 by Blaha, Gregor, Alboreggia, Giulia, Rodriguez, Isaac, Pellecchia, Maurizio

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Mixture-Based Screening of Focused Combinatorial Libraries by NMR: Application to the Antiapoptotic Protein hMcl‑1 by Alboreggia, Giulia, Udompholkul, Parima, Baggio, Carlo, Pellecchia, Maurizio

“…We report on an innovative ligand discovery strategy based on protein NMR-based screening of a combinatorial library of ∼125,000 compounds that was arranged in…”
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Covalent Targeting of Histidine Residues with Aryl Fluorosulfates: Application to Mcl-1 BH3 Mimetics by Alboreggia, Giulia, Udompholkul, Parima, Atienza, Emma L., Muzzarelli, Kendall, Assar, Zahra, Pellecchia, Maurizio

“…Covalent drugs provide pharmacodynamic and pharmacokinetic advantages over reversible agents. However, covalent strategies have been developed mostly to target…”
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Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl‑1 by Alboreggia, Giulia, Udompholkul, Parima, Baggio, Carlo, Muzzarelli, Kendall, Assar, Zahra, Pellecchia, Maurizio

“…Several novel and effective cysteine targeting (Cys) covalent drugs are in clinical use. However, the target area containing a druggable Cys residue is…”
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