Search Results - "Albold, Sabine"

Structure-Based Design and Discovery of New M2 Receptor Agonists by Fish, Inbar, Stößel, Anne, Eitel, Katrin, Valant, Celine, Albold, Sabine, Huebner, Harald, Möller, Dorothee, Clark, Mary J, Sunahara, Roger K, Christopoulos, Arthur, Shoichet, Brian K, Gmeiner, Peter

“…Muscarinic receptor agonists are characterized by apparently strict restraints on their tertiary or quaternary amine and their distance to an ester or related…”
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Metabotropic glutamate receptor 5 (mGlu5)‐positive allosteric modulators differentially induce or potentiate desensitization of mGlu5 signaling in recombinant cells and neurons by Hellyer, Shane D., Albold, Sabine, Sengmany, Kathy, Singh, Junaid, Leach, Katie, Gregory, Karen J.

“…Allosteric modulators of metabotropic glutamate receptor 5 (mGlu5) are a promising therapeutic strategy for a number of neurological disorders. Multiple…”
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β2 -adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer by Chang, Aeson, Le, Caroline P, Walker, Adam K, Creed, Sarah J, Pon, Cindy K, Albold, Sabine, Carroll, Dominic, Halls, Michelle L, Robert Lane, J, Riedel, Bernhard, Ferrari, Davide, Sloan, Erica K

“…Highlights • β2-adrenoceptors on MDA-MB-231HM breast cancer cells contribute to stress-enhanced metastasis. • β2-adrenoceptor signaling regulates a shift to…”
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Structure-based discovery of selective positive allosteric modulators of antagonists for the M₂ muscarinic acetylcholine receptor by Korczynska, Magdalena, Clark, Mary J., Valant, Celine, Xu, Jun, Von Moo, Ee, Albold, Sabine, Weiss, Dahlia R., Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C., Lyda, Brent R., May, Lauren T., Baltos, Jo-Anne, Sexton, Patrick M., Kobilka, Brian K., Christopoulos, Arthur, Shoichet, Brian K., Sunahara, Roger K.

“…Subtype-selective antagonists for muscarinic acetylcholine receptors (mAChRs) have long been elusive, owing to the highly conserved orthosteric binding site…”
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Metabotropic glutamate receptor 5 (mGlu 5 )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu 5 signaling in recombinant cells and neurons by Hellyer, Shane D, Albold, Sabine, Sengmany, Kathy, Singh, Junaid, Leach, Katie, Gregory, Karen J

“…Allosteric modulators of metabotropic glutamate receptor 5 (mGlu ) are a promising therapeutic strategy for a number of neurological disorders. Multiple mGlu…”
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Co‐activation of adenosine and glutamate receptors modulates signaling in primary brain cell cultures by Gregory, Karen J., Hellyer, Shane D., Albold, Sabine, Leach, Katie, May, Lauren T.

“…G protein‐coupled receptors (GPCRs) represent the largest class of targets for current therapeutics. Two distinct modulatory GPCRs within the CNS, the…”
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Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology by Sengmany, Kathy, Hellyer, Shane D., Albold, Sabine, Wang, Taide, Conn, P. Jeffrey, May, Lauren T., Christopoulos, Arthur, Leach, Katie, Gregory, Karen J.

“…Allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu5) have been proposed as potential therapies for various CNS disorders. These…”
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β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion by Creed, Sarah J, Le, Caroline P, Hassan, Mona, Pon, Cindy K, Albold, Sabine, Chan, Keefe T, Berginski, Matthew E, Huang, Zhendong, Bear, James E, Lane, J Robert, Halls, Michelle L, Ferrari, Davide, Nowell, Cameron J, Sloan, Erica K

“…For efficient metastatic dissemination, tumor cells form invadopodia to degrade and move through three-dimensional extracellular matrix. However, little is…”
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Structure-Based Design and Discovery of New M 2 Receptor Agonists by Fish, Inbar, Stößel, Anne, Eitel, Katrin, Valant, Celine, Albold, Sabine, Huebner, Harald, Möller, Dorothee, Clark, Mary J, Sunahara, Roger K, Christopoulos, Arthur, Shoichet, Brian K, Gmeiner, Peter

“…Muscarinic receptor agonists are characterized by apparently strict restraints on their tertiary or quaternary amine and their distance to an ester or related…”
Get full text

Structure-based discovery of selective positive allosteric modulators of antagonists for the M^sub 2^ muscarinic acetylcholine receptor by Korczynska, Magdalena, Clark, Mary J, Valant, Celine, Xu, Jun, Moo, Ee Von, Albold, Sabine, Weiss, Dahlia R, Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C, Lyda, Brent R, May, Lauren T, Baltos, Jo-Anne, Sexton, Patrick M, Kobilka, Brian K, Christopoulos, Arthur, Shoichet, Brian K, Sunahara, Roger K

“…Subtype-selective antagonists for muscarinic acetylcholine receptors (mAChRs) have long been elusive, owing to the highly conserved orthosteric binding site…”
Get full text

Structure-based discovery of selective positive allosteric modulators of antagonists for the M 2 muscarinic acetylcholine receptor by Korczynska, Magdalena, Clark, Mary J, Valant, Celine, Xu, Jun, Moo, Ee Von, Albold, Sabine, Weiss, Dahlia R, Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C, Lyda, Brent R, May, Lauren T, Baltos, Jo-Anne, Sexton, Patrick M, Kobilka, Brian K, Christopoulos, Arthur, Shoichet, Brian K, Sunahara, Roger K

“…Subtype-selective antagonists for muscarinic acetylcholine receptors (mAChRs) have long been elusive, owing to the highly conserved orthosteric binding site…”
Get full text

2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion by Creed, Sarah J, Le, Caroline P, Hassan, Mona, Pon, Cindy K, Albold, Sabine, Chan, Keefe T, Berginski, Matthew E, Huang, Zhendong, Bear, James E, Lane, J. Robert, Halls, Michelle L, Ferrari, Davide, Nowell, Cameron J, Sloan, Erica K

“…Introduction For efficient metastatic dissemination, tumor cells form invadopodia to degrade and move through three-dimensional extracellular matrix. However,…”
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β 2 -Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer by Chang, Aeson, Le, Caroline P., Walker, Adam K., Creed, Sarah J., Pon, Cindy K., Albold, Sabine, Carroll, Dominic, Halls, Michelle L., Lane, J. Robert, Riedel, Bernhard, Ferrari, Davide, Sloan, Erica K.

“…Chronic stress accelerates metastasis - the main cause of death in cancer patients - through the activation of beta -adrenoceptors ( beta ARs). We have…”
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Beta2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion by Creed, Sarah J, Le, Caroline P, Hassan, Mona, Pon, Cindy K, Albold, Sabine, Chan, Keefe T, Berginski, Matthew E, Huang, Zhendong, Bear, James E, Lane, J Robert, Halls, Michelle L, Ferrari, Davide, Nowell, Cameron J, Sloan, Erica K

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