Search Results - "Alberton Perelló, Marcia"

Synthesis and Antimycobacterial Activity of 3-Phenyl-1H-indoles by Jardim Etchart, Renata, Rambo, Raoní S., Lopes Abbadi, Bruno, Sperotto, Nathalia, Ev Neves, Christiano, Fries Silva, Fernanda, Dornelles, Maiele, Duarte, Lovaine, Souza Macchi, Fernanda, Alberton Perelló, Marcia, Vescia Lourega, Rogério, Valim Bizarro, Cristiano, Basso, Luiz Augusto, Machado, Pablo

“…Tuberculosis has been described as a global health crisis since the 1990s, with an estimated 1.4 million deaths in the last year. Herein, a series of 20…”
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Crystal structure of dihydroneopterin aldolase from Mycobacterium tuberculosis associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, in vitro toxicity and antitubercular activity by Czeczot, Alexia de Matos, Muniz, Mauro Neves, Perelló, Marcia Alberton, Silva, Éverton Edésio Dinis, Timmers, Luís Fernando Saraiva Macedo, Berger, Andresa, Gonzalez, Laura Calle, Arraché Gonçalves, Guilherme, Moura, Sidnei, Machado, Pablo, Bizarro, Cristiano Valim, Basso, Luiz Augusto

“…The crystallographic structure of the FolB enzyme from ( FolB), complexed with its inhibitor 8-mercaptoguanine (8-MG), was elucidated at a resolution of 1.95…”
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Exploring Scaffold Hopping for Novel 2‑(Quinolin-4-yloxy)acetamides with Enhanced Antimycobacterial Activity by Borsoi, Ana Flávia, Silva Ramos, Alessandro, Sperotto, Nathalia, Abbadi, Bruno Lopes, Souza Macchi Hopf, Fernanda, da Silva Dadda, Adilio, Scheibler Rambo, Raoní, Neves Muniz, Mauro, Delgado Paz, Josiane, Silveira Grams, Estevão, Fries da Silva, Fernanda, Pissinate, Kenia, Galina, Luiza, Calle González, Laura, Silva Duarte, Lovaine, Alberton Perelló, Marcia, de Matos Czeczot, Alexia, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Machado, Pablo

“…Utilizing a scaffold-hopping strategy from the drug candidate telacebec, a novel series of 2-(quinolin-4-yloxy)­acetamides was synthesized and evaluated as…”
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Antitubercular Activity of Novel 2‑(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties by Borsoi, Ana Flávia, Alice, Laura Manzoli, Sperotto, Nathalia, Ramos, Alessandro Silva, Abbadi, Bruno Lopes, Macchi Hopf, Fernanda Souza, Silva Dadda, Adilio da, Rambo, Raoní S., Madeira Silva, Rodrigo Braccini, Paz, Josiane Delgado, Pissinate, Kenia, Muniz, Mauro Neves, Neves, Christiano Ev, Galina, Luiza, González, Laura Calle, Perelló, Marcia Alberton, de Matos Czeczot, Alexia, Leyser, Mariana, de Oliveira, Sílvia Dias, de Araújo Lock, Graziela, de Araújo, Bibiana Verlindo, Costa, Teresa Dalla, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Machado, Pablo

“…Using cycloalkyl and electron-donating groups to decrease the carbonyl electrophilicity, a novel series of 2-(quinoline-4-yloxy)­acetamides was synthesized and…”
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Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation by Paz, Josiane Delgado, Denise de Moura Sperotto, Nathalia, Ramos, Alessandro Silva, Pissinate, Kenia, da Silva Rodrigues Junior, Valnês, Abbadi, Bruno Lopes, Borsoi, Ana Flávia, Rambo, Raoní Scheibler, Corso Minotto, Ana Carolina, da Silva Dadda, Adilio, Galina, Luiza, Macchi Hopf, Fernanda Souza, Muniz, Mauro Neves, Borges Martinelli, Leonardo Kras, Roth, Candida Deves, Madeira Silva, Rodrigo Braccini, Perelló, Marcia Alberton, de Matos Czeczot, Alexia, Neves, Christiano Ev, Duarte, Lovaine Silva, Leyser, Mariana, Dias de Oliveira, Sílvia, Bizarro, Cristiano Valim, Machado, Pablo, Basso, Luiz Augusto

“…Herein a series of 4-aminoquinolines were synthesized in an attempt to optimize and study the structural features related to LABIO-17 biological activity, a…”
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Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments by Freitas de Freitas, Talita, Roth, Candida Deves, Abbadi, Bruno Lopes, Hopf, Fernanda Souza Macchi, Perelló, Marcia Alberton, de Matos Czeczot, Alexia, de Souza, Eduardo Vieira, Borsoi, Ana Flávia, Machado, Pablo, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Timmers, Luis Fernando Saraiva Macedo

“…Tuberculosis (TB) is one of the main causes of death from a single pathological agent, Mycobacterium tuberculosis ( Mtb ). In addition, the emergence of…”
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Identification of antimycobacterial 8-hydroxyquinoline derivatives as in vitro enzymatic inhibitors of Mycobacterium tuberculosis enoyl-acyl carrier protein reductase by Joaquim, Angélica Rocha, Lopes, Marcela Silva, Fortes, Isadora Serraglio, de Bem Gentz, Caroline, de Matos Czeczot, Alexia, Perelló, Marcia Alberton, Roth, Candida Deves, Vainstein, Marilene Henning, Basso, Luiz Augusto, Bizarro, Cristiano Valim, Machado, Pablo, de Andrade, Saulo Fernandes

“…[Display omitted] •Small library of 8-hydroxyquinoline (8HQ) was evaluated against M. tuberculosis.•9 derivatives were active against the mycobacteria.•5a, 5c,…”
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Synthesis and Antimycobacterial Evaluation of N -(4-(Benzyloxy)benzyl)-4-aminoquinolines by Grams, Estevão Silveira, Silva Ramos, Alessandro, Neves Muniz, Mauro, Rambo, Raoní S, Alberton Perelló, Marcia, Sperotto, Nathalia, Calle González, Laura, Duarte, Lovaine Silva, Galina, Luiza, Silva Dadda, Adilio, Arraché Gonçalves, Guilherme, Valim Bizarro, Cristiano, Basso, Luiz Augusto, Machado, Pablo

“…Tuberculosis remains a global health problem that affects millions of people around the world. Despite recent efforts in drug development, new alternatives are…”
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Targeting thymidine phosphorylase inhibition in human colorectal cancer xenografts by Sperotto, Nathalia D. de Moura, Silva, Rodrigo Braccini Madeira, Perelló, Marcia Alberton, Borsoi, Ana Flávia, da Silva Dadda, Adilio, Roth, Candida Deves, Freitas, Raquel Dal Sasso, de Souza, Ana Paula Duarte, Freitas, Deise do Nascimento de, Picada, Jaqueline Nascimento, de Sousa, Jayne Torres, Nabinger, Débora Dreher, Altenhofen, Stefani, Bonan, Carla Denise, Rodrigues-Junior, Valnês S., Bizarro, Cristiano Valim, Basso, Luiz Augusto, Machado, Pablo

“…Human thymidine phosphorylase (hTP) is overexpressed in several solid tumors and is commonly associated with aggressiveness and unfavorable prognosis…”
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Evaluation of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase (DAHPS) as a Vulnerable Target in Mycobacterium tuberculosis by Galina, Luiza, Hopf, Fernanda S. M., Abbadi, Bruno Lopes, Sperotto, Nathalia D. de Moura, Czeczot, Alexia M., Duque-Villegas, Mario A., Perello, Marcia Alberton, Matter, Letícia Beatriz, de Souza, Eduardo Vieira, Parish, Tanya, Machado, Pablo, Basso, Luiz A., Bizarro, Cristiano V.

“…Tuberculosis (TB) remains one of the leading causes of death due to a single pathogen. The emergence and proliferation of multidrug-resistant (MDR-TB) and…”
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EPSP Synthase-Depleted Cells Are Aromatic Amino Acid Auxotrophs in Mycobacterium smegmatis by Duque-Villegas, Mario Alejandro, Abbadi, Bruno Lopes, Romero, Paulo Ricardo, Matter, Letícia Beatriz, Galina, Luiza, Dalberto, Pedro Ferrari, Rodrigues-Junior, Valnês da Silva, Ducati, Rodrigo Gay, Roth, Candida Deves, Rambo, Raoní Scheibler, de Souza, Eduardo Vieira, Perello, Marcia Alberton, Morbidoni, Héctor Ricardo, Machado, Pablo, Basso, Luiz Augusto, Bizarro, Cristiano Valim

“…The epidemiological importance of mycobacterial species is indisputable, and the necessity to find new molecules that can inhibit their growth is urgent. The…”
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Identification and characterization of new structural scaffolds modulating the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro by Virginia Carla de Almeida Falcão, Alexia de Matos Czeczot, Alexia de Matos Czeczot, Mohammad Maqusood Alam, Kyu-Ho Paul Park, Jinyeong Heo, Minjeong Woo, Ana Micaela Camini, Luis Fernando Saraiva Macedo Timmers, Luis Fernando Saraiva Macedo Timmers, Luis Fernando Saraiva Macedo Timmers, David Shum, Marcia Alberton Perelló, Luiz Augusto Basso, Luiz Augusto Basso, Luiz Augusto Basso, Pablo Machado, Pablo Machado, Pablo Machado, Cristiano Valim Bizarro, Cristiano Valim Bizarro, Vincent Delorme

“…IntroductionAntifolates were among the first broad-spectrum compounds used as antimycobacterial agents and can still be of use when no other therapeutic…”
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