Search Results - "Albertini, Richard"

The lower alkyl methacrylates: Genotoxic profile of non-carcinogenic compounds by Albertini, Richard J.

“…All of the lower alkyl methacrylates are high production chemicals with potential for human exposure. The genotoxicity of seven mono-functional alkyl esters of…”
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Acrylonitrile's genotoxicity profile: mutagenicity in search of an underlying molecular mechanism by Albertini, Richard J., Kirman, Christopher R., Strother, Dale E.

“…Acrylonitrile (ACN) is a known rodent and possible human carcinogen. There have also been concerns as to it causing adverse reproductive health effects…”
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Mutagenicity monitoring in humans: Global versus specific origin of mutations by Albertini, Richard J., Kaden, Debra A.

“…•T-cell-based in vivo mutation assays may not tell us where mutations originated.•Mutations originating in bone marrow cells are most relevant for…”
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Biomarkers in Toxicology and Risk Assessment: Informing Critical Dose–Response Relationships by Swenberg, James A, Fryar-Tita, Elizabeth, Jeong, Yo-Chan, Boysen, Gunnar, Starr, Thomas, Walker, Vernon E, Albertini, Richard J

“…Tremendous advances have been made in the study of biomarkers related to carcinogenesis during the past 20 years. This perspective will briefly review…”
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A proposal for assessing study quality: Biomonitoring, Environmental Epidemiology, and Short-lived Chemicals (BEES-C) instrument by LaKind, Judy S., Sobus, Jon R., Goodman, Michael, Barr, Dana Boyd, Fürst, Peter, Albertini, Richard J., Arbuckle, Tye E., Schoeters, Greet, Tan, Yu-Mei, Teeguarden, Justin, Tornero-Velez, Rogelio, Weisel, Clifford P.

“…The quality of exposure assessment is a major determinant of the overall quality of any environmental epidemiology study. The use of biomonitoring as a tool…”
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Do chromosome changes in blood cells implicate formaldehyde as a leukemogen? by Albertini, Richard J., Kaden, Debra A.

“…Formaldehyde (FA) is a mutagenic chemical - a property mitigated in vivo by rapid detoxification and limited tissue distribution following inhalation of the…”
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Genotoxicity as a toxicologically relevant endpoint to inform risk assessment: A case study with ethylene oxide by Gollapudi, Bala Bhaskar, Su, Steave, Li, Abby A., Johnson, George E., Reiss, Richard, Albertini, Richard J.

“…The purpose of the present investigation is to analyze the in vivo genotoxicity dose–response data of ethylene oxide (EO) and the applicability of the derived…”
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Clonality, trafficking, and molecular alterations among Hprt mutant T lymphocytes isolated from control mice versus mice treated with N-ethyl-N-nitrosourea by Judice, Stephen A, Sussman, Hillary E, Walker, Dale M, O'Neill, J Patrick, Albertini, Richard J, Walker, Vernon E

“…Mutations in T lymphocytes (T-cells) are informative quantitative markers for environmental mutagen exposures, but risk extrapolations from rodent models to…”
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Both PIGA and PIGL mutations cause GPI-a deficient isolates in the Tk6 cell line by Nicklas, Janice A., Carter, Elizabeth W., Albertini, Richard J.

“…Molecular analysis of proaerolysin selected glycosylphosphatidylinositol anchor (GPI‐a) deficient isolates in the TK6 cell line was performed. Initial studies…”
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Molecular characterization of hypoxanthine guanine phosphoribosyltransferase mutant T cells in human blood: The concept of surrogate selection for immunologically relevant cells by Kaitz, Noah A., Zuleger, Cindy L., Yu, Peng, Newton, Michael A., Albertini, Richard J., Albertini, Mark R.

“…Somatic cell gene mutations arise in vivo due to replication errors during DNA synthesis occurring spontaneously during normal DNA synthesis or as a result of…”
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Longitudinal study of t‐cell somatic mutations conferring glycosylphosphatidylinositol‐anchor deficiency in gulf war I veterans exposed to depleted uranium by Albertini, Richard J., Nicklas, Janice A., Vacek, Pamela M., Carter, Elizabeth W., McDiarmid, Melissa

“…Fifty Veterans of the first Gulf War in 1991 exposed to depleted uranium (DU) were studied for glycosylphosphatidylinositol‐anchor (GPIa) deficient T‐cell…”
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Vinyl acetate monomer (VAM) genotoxicity profile: Relevance for carcinogenicity by Albertini, Richard J.

“…Abstract Vinyl acetate monomer (VAM) is a site-of-contact carcinogen in rodents. It is also DNA reactive and mutagenic, but only after its carboxylesterase…”
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Molecular analysis of glycosylphosphatidylinositol anchor deficient aerolysin resistant isolates in gulf war i veterans exposed to depleted uranium by Nicklas, Janice A., Vacek, Pamela M., Carter, Elizabeth W., McDiarmid, Melissa, Albertini, Richard J.

“…During the First Gulf War (1991) over 100 servicemen sustained depleted uranium (DU) exposure through wound contamination, inhalation, and shrapnel. The…”
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1,3-Butadiene metabolite 1,2,3,4 diepoxybutane induces DNA adducts and micronuclei but not t(9;22) translocations in human cells by Walker, Vernon E., Degner, Amanda, Carter, Elizabeth W., Nicklas, Janice A., Walker, Dale M., Tretyakova, Natalia, Albertini, Richard J.

“…Epidemiological studies of 1,3-butadiene (BD) exposures have reported a possible association with chronic myelogenous leukemia (CML), which is defined by the…”
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Cellular response to the genotoxic insult: the question of threshold for genotoxic carcinogens by Greim, Helmut, Albertini, Richard J

“…Maintenance of cellular integrity is crucial for its physiological function, which is constantly threatened by DNA damage arising from numerous intrinsic and…”
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Frequencies of micronucleated reticulocytes, a dosimeter of DNA double-strand breaks, in infants receiving computed tomography or cardiac catheterization by Khattab, Mona, Walker, Dale M., Albertini, Richard J., Nicklas, Janice A., Lundblad, Lennart K.A., Vacek, Pamela M., Walker, Vernon E.

“…•Micronucleated reticulocytes (MN-RETs) were measured before versus after CT scans.•Dose-related increases in MN-RET levels occurred 48h after CT scans in…”
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Formaldehyde exposure and leukemia: Critical review and reevaluation of the results from a study that is the focus for evidence of biological plausibility by Gentry, P. Robinan, Rodricks, Joseph V., Turnbull, Duncan, Bachand, Annette, Van Landingham, Cynthia, Shipp, Annette M., Albertini, Richard J., Irons, Richard

“…Abstract A recent study (Zhang et al., 2010) has provided results attributed to aneuploidy in circulating stem cells that has been characterized as providing…”
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Formation of 1,2:3,4-Diepoxybutane-Specific Hemoglobin Adducts in 1,3-Butadiene Exposed Workers by Boysen, Gunnar, Georgieva, Nadia I., Bordeerat, Narisa K., Šram, Radim J., Vacek, Pamela, Albertini, Richard J., Swenberg, James A.

“…1,3-Butadiene (BD) is an important industrial chemical that is classified as a human carcinogen. BD carcinogenicity has been attributed to its metabolism to…”
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Mutagenicity monitoring following battlefield exposures: Longitudinal study of HPRT mutations in gulf war i veterans exposed to depleted uranium by Albertini, Richard J., Vacek, Pamela M., Carter, Elizabeth W., Nicklas, Janice A., Squibb, Katherine S., Gucer, Patricia W., Engelhardt, Susan M., McDiarmid, Melissa A.

“…A total of 70 military Veterans have been monitored for HPRT T‐cell mutations in five separate studies at 2‐year intervals over an 8‐year period. Systemic…”
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IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans by Albertini, Richard J, Anderson, Diana, Douglas, George R, Hagmar, Lars, Hemminki, Kari, Merlo, Franco, Natarajan, A.T, Norppa, Hannu, Shuker, David E.G, Tice, Raymond, Waters, Michael D, Aitio, Antero

“…The purpose of these guidelines is to provide concise guidance on the planning, performing and interpretation of studies to monitor groups or individuals…”
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