Search Results - "Albers, Harald M H G"

Chemical Evolution of Autotaxin Inhibitors by Albers, Harald M. H. G, Ovaa, Huib

“…Albers and Ovaa examine the chemical evolution of autotaxin inhibitors with regard to structure and synthesis…”
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Structure-Based Design of Novel Boronic Acid-Based Inhibitors of Autotaxin by Albers, Harald M. H. G, Hendrickx, Loes J. D, van Tol, Rob J. P, Hausmann, Jens, Perrakis, Anastassis, Ovaa, Huib

“…Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA)…”
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Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin by Albers, Harald M. H. G, van Meeteren, Laurens A, Egan, David A, van Tilburg, Erica W, Moolenaar, Wouter H, Ovaa, Huib

“…Autotaxin (ATX) is an extracellular enzyme that hydrolyzes lysophosphatidylcholine (LPC) to produce the lipid mediator lysophosphatidic acid (LPA). The ATX−LPA…”
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Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation by Albers, Harald M.H.G, Dong, Anping, van Meeteren, Laurens A, Egan, David A, Sunkara, Manjula, van Tilburg, Erica W, Schuurman, Karianne, van Tellingen, Olaf, Morris, Andrew J, Smyth, Susan S, Moolenaar, Wouter H, Ovaa, Huib

“…Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions as a lysophospholipase D to produce the lipid mediator…”
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Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis by Bai, Zhongbin, Cai, Linjun, Umemoto, Eiji, Takeda, Akira, Tohya, Kazuo, Komai, Yutaka, Veeraveedu, Punniyakoti Thanikachalam, Hata, Erina, Sugiura, Yuki, Kubo, Akiko, Suematsu, Makoto, Hayasaka, Haruko, Okudaira, Shinichi, Aoki, Junken, Tanaka, Toshiyuki, Albers, Harald M H G, Ovaa, Huib, Miyasaka, Masayuki

“…Lymphocyte extravasation from the high endothelial venules (HEVs) of lymph nodes is crucial for the maintenance of immune homeostasis, but its molecular…”
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Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right asymmetry in zebrafish by Lai, Shih-Lei, Yao, Wan-Ling, Tsao, Ku-Chi, Houben, Anna J S, Albers, Harald M H G, Ovaa, Huib, Moolenaar, Wouter H, Lee, Shyh-Jye

“…Left-right (L-R) patterning is essential for proper organ morphogenesis and function. Calcium fluxes in dorsal forerunner cells (DFCs) are known to regulate…”
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Integrating Chemical and Genetic Silencing Strategies To Identify Host Kinase-Phosphatase Inhibitor Networks That Control Bacterial Infection by Albers, Harald M. H. G, Kuijl, Coenraad, Bakker, Jeroen, Hendrickx, Loes, Wekker, Sharida, Farhou, Nadha, Liu, Nora, Blasco-Moreno, Bernat, Scanu, Tiziana, den Hertog, Jeroen, Celie, Patrick, Ovaa, Huib, Neefjes, Jacques

“…Every year three million people die as a result of bacterial infections, and this number may further increase due to resistance to current antibiotics. These…”
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Development of an Activity-Based Probe for Autotaxin by Cavalli, Silvia, Houben, Anna J. S., Albers, Harald M. H. G., van Tilburg, Erica W., de Ru, Arnoud, Aoki, Junken, van Veelen, Peter, Moolenaar, Wouter H., Ovaa, Huib

“…Autotaxin (ATX), or ecto‐nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted lysophospholipase D that hydrolyses lysophosphatidylcholine into…”
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Structural basis of substrate discrimination and integrin binding by autotaxin by Morris, Andrew J, Moolenaar, Wouter H, Perrakis, Anastassis, Hausmann, Jens, Kamtekar, Satwik, Christodoulou, Evangelos, Day, Jacqueline E, Wu, Tao, Fulkerson, Zachary, Albers, Harald M H G, van Meeteren, Laurens A, Houben, Anna J S, van Zeijl, Leonie, Jansen, Silvia, Andries, Maria, Hall, Troii, Pegg, Lyle E, Benson, Timothy E, Kasiem, Mobien, Harlos, Karl, Kooi, Craig W Vander, Smyth, Susan S, Ovaa, Huib, Bollen, Mathieu

“…The enzyme autotaxin (ATX) produces the lipid mediator LPA to stimulate cell migration and proliferation. The crystal structures of rat ATX, in its apo and…”
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Controlled Supramolecular Oligomerization of C3-Symmetrical Molecules in Water: The Impact of Hydrophobic Shielding by Besenius, Pol, van den Hout, Kelly P., Albers, Harald M. H. G., de Greef, Tom F. A., Olijve, Luuk L. C., Hermans, Thomas M., de Waal, Bas F. M., Bomans, Paul H. H., Sommerdijk, Nico A. J. M., Portale, Giuseppe, Palmans, Anja R. A., van Genderen, Marcel H. P., Vekemans, Jef A. J. M., Meijer, E. W.

“…The supramolecular oligomerization of three water‐soluble C3‐symmetrical discotic molecules is reported. The compounds all possess benzene‐1,3,5‐tricarboxamide…”
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Cover Picture: Development of an Activity-Based Probe for Autotaxin (ChemBioChem 16/2010) by Cavalli, Silvia, Houben, Anna J. S., Albers, Harald M. H. G., van Tilburg, Erica W., de Ru, Arnoud, Aoki, Junken, van Veelen, Peter, Moolenaar, Wouter H., Ovaa, Huib

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Controlled Supramolecular Oligomerization of C 3 ‐Symmetrical Molecules in Water: The Impact of Hydrophobic Shielding by Besenius, Pol, van den Hout, Kelly P., Albers, Harald M. H. G., de Greef, Tom F. A., Olijve, Luuk L. C., Hermans, Thomas M., de Waal, Bas F. M., Bomans, Paul H. H., Sommerdijk, Nico A. J. M., Portale, Giuseppe, Palmans, Anja R. A., van Genderen, Marcel H. P., Vekemans, Jef A. J. M., Meijer, E. W.

“…Abstract The supramolecular oligomerization of three water‐soluble C 3 ‐symmetrical discotic molecules is reported. The compounds all possess…”
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