Search Results - "Alberch, Jordi"

Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy by Fernández-García, Sara, Sancho-Balsells, Anna, Longueville, Sophie, Hervé, Denis, Gruart, Agnès, Delgado-García, José María, Alberch, Jordi, Giralt, Albert

“…Astrocytes have emerged as crucial regulators of neuronal network activity, synapse formation, and underlying behavioral and cognitive processes. Despite some…”
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Pyk2 in the amygdala modulates chronic stress sequelae via PSD-95-related micro-structural changes by Montalban, Enrica, Al-Massadi, Omar, Sancho-Balsells, Anna, Brito, Verónica, de Pins, Benoit, Alberch, Jordi, Ginés, Silvia, Girault, Jean-Antoine, Giralt, Albert

“…Major depressive disorder (MDD) is a common disorder with a variety of symptoms including mood alterations, anhedonia, sleep and appetite disorders, and…”
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Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's disease by Sánchez‐Danés, Adriana, Richaud‐Patin, Yvonne, Carballo‐Carbajal, Iria, Jiménez‐Delgado, Senda, Caig, Carles, Mora, Sergio, Di Guglielmo, Claudia, Ezquerra, Mario, Patel, Bindiben, Giralt, Albert, Canals, Josep M., Memo, Maurizio, Alberch, Jordi, López‐Barneo, José, Vila, Miquel, Cuervo, Ana Maria, Tolosa, Eduard, Consiglio, Antonella, Raya, Angel

“…Induced pluripotent stem cells (iPSC) offer an unprecedented opportunity to model human disease in relevant cell types, but it is unclear whether they could…”
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Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model by Giralt, Albert, Brito, Veronica, Chevy, Quentin, Simonnet, Clémence, Otsu, Yo, Cifuentes-Díaz, Carmen, de Pins, Benoit, Coura, Renata, Alberch, Jordi, Ginés, Sílvia, Poncer, Jean-Christophe, Girault, Jean-Antoine

“…The structure and function of spines and excitatory synapses are under the dynamic control of multiple signalling networks. Although tyrosine phosphorylation…”
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RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease by Pérez-Sisqués, Leticia, Sancho-Balsells, Anna, Solana-Balaguer, Júlia, Campoy-Campos, Genís, Vives-Isern, Marcel, Soler-Palazón, Ferran, Anglada-Huguet, Marta, López-Toledano, Miguel-Ángel, Mandelkow, Eva-Maria, Alberch, Jordi, Giralt, Albert, Malagelada, Cristina

“…RTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death. Its downregulation in Parkinson’s and…”
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Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease by Moreno-Delgado, David, Puigdellívol, Mar, Moreno, Estefanía, Rodríguez-Ruiz, Mar, Botta, Joaquín, Gasperini, Paola, Chiarlone, Anna, Howell, Lesley A, Scarselli, Marco, Casadó, Vicent, Cortés, Antoni, Ferré, Sergi, Guzmán, Manuel, Lluís, Carmen, Alberch, Jordi, Canela, Enric I, Ginés, Silvia, McCormick, Peter J

“…Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell…”
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Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons by Sancho-Balsells, Anna, Borràs-Pernas, Sara, Brito, Verónica, Alberch, Jordi, Girault, Jean-Antoine, Giralt, Albert

“…Chronic stress is a core risk factor for developing a myriad of neurological disorders, including major depression. The chronicity of such stress can lead to…”
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Postnatal Foxp2 regulates early psychiatric-like phenotypes and associated molecular alterations in the R6/1 transgenic mouse model of Huntington's disease by Rodríguez-Urgellés, Ened, Rodríguez-Navarro, Irene, Ballasch, Iván, del Toro, Daniel, del Castillo, Ignacio, Brito, Verónica, Alberch, Jordi, Giralt, Albert

“…Huntington's Disease (HD) is a devastating disorder characterized by a triad of motor, psychiatric and cognitive manifestations. Psychiatric and emotional…”
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Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease by Saavedra, Ana, Giralt, Albert, Arumí, Helena, Alberch, Jordi, Pérez-Navarro, Esther

“…Huntington's disease (HD) patients and mouse models show learning and memory impairment associated with hippocampal dysfunction. The neuronal nitric oxide…”
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Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia by López-Molina, Laura, Sancho-Balsells, Anna, Al-Massadi, Omar, Montalban, Enrica, Alberch, Jordi, Arranz, Belén, Girault, Jean-Antoine, Giralt, Albert

“…Pyk2 has been shown previously to be involved in several psychological and cognitive alterations related to stress, Huntington's disease, and Alzheimer's…”
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VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosis by García-García, Esther, Ramón-Lainez, Alba, Conde-Berriozabal, Sara, del Toro, Daniel, Escaramis, Georgia, Giralt, Albert, Masana, Mercè, Alberch, Jordi, Rodríguez, Manuel J.

“…Chorea-acanthocytosis (ChAc) is an inherited neurodegenerative movement disorder caused by VPS13A gene mutations leading to the absence of protein expression…”
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Impaired TrkB-mediated ERK1/2 Activation in Huntington Disease Knock-in Striatal Cells Involves Reduced p52/p46 Shc Expression by Ginés, Silvia, Paoletti, Paola, Alberch, Jordi

“…Altered neurotrophic support as a result of reduced brain-derived neurotrophic factor (BDNF) expression and trafficking has been revealed as a key factor in…”
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PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model by Giralt, Albert, Saavedra, Ana, Carretón, Olga, Arumí, Helena, Tyebji, Shiraz, Alberch, Jordi, Pérez-Navarro, Esther

“…ABSTRACT Huntington's disease (HD) causes motor disturbances, preceded by cognitive impairment, in patients and mouse models. We showed that increased…”
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Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration by Díaz-Hernández, Miguel, Díez-Zaera, María, Sánchez-Nogueiro, Jesús, Gómez-Villafuertes, Rosa, Canals, Josep M, Alberch, Jordi, Miras-Portugal, María Teresa, Lucas, José J

“…The precise mechanism by which mutant huntingtin elicits its toxicity remains unknown. However, synaptic alterations and increased susceptibility to neuronal…”
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Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation by Comella-Bolla, Andrea, Orlandi, Javier G., Miguez, Andrés, Straccia, Marco, García-Bravo, María, Bombau, Georgina, Galofré, Mireia, Sanders, Phil, Carrere, Jordi, Segovia, José Carlos, Blasi, Joan, Allen, Nicholas D., Alberch, Jordi, Soriano, Jordi, Canals, Josep M.

“…Human pluripotent stem cells (hPSCs) are a powerful tool for modelling human development. In recent years, hPSCs have become central in cell-based therapies…”
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Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus by del Toro, Daniel, Alberch, Jordi, Lázaro-Diéguez, Francisco, Martín-Ibáñez, Raquel, Xifró, Xavier, Egea, Gustavo, Canals, Josep M

“…Huntingtin regulates post-Golgi trafficking of secreted proteins. Here, we studied the mechanism by which mutant huntingtin impairs this process…”
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Reduced Fractalkine Levels Lead to Striatal Synaptic Plasticity Deficits in Huntington’s Disease by Kim, Anya, García-García, Esther, Straccia, Marco, Comella-Bolla, Andrea, Miguez, Andrés, Masana, Mercè, Alberch, Jordi, Canals, Josep M., Rodríguez, Manuel J.

“…Huntington’s disease (HD) is an inherited neurodegenerative disorder in which the striatum is the most affected brain region. Although a chronic inflammatory…”
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Aberrant epigenome in iPSC‐derived dopaminergic neurons from Parkinson's disease patients by Fernández‐Santiago, Rubén, Carballo‐Carbajal, Iria, Castellano, Giancarlo, Torrent, Roger, Richaud, Yvonne, Sánchez‐Danés, Adriana, Vilarrasa‐Blasi, Roser, Sánchez‐Pla, Alex, Mosquera, José Luis, Soriano, Jordi, López‐Barneo, José, Canals, Josep M, Alberch, Jordi, Raya, Ángel, Vila, Miquel, Consiglio, Antonella, Martín‐Subero, José I, Ezquerra, Mario, Tolosa, Eduardo

“…The epigenomic landscape of Parkinson's disease (PD) remains unknown. We performed a genomewide DNA methylation and a transcriptome studies in induced…”
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A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin by Damiano, Maria, Diguet, Elsa, Malgorn, Carole, D'Aurelio, Marilena, Galvan, Laurie, Petit, Fanny, Benhaim, Lucile, Guillermier, Martine, Houitte, Diane, Dufour, Noelle, Hantraye, Philippe, Canals, Josep M, Alberch, Jordi, Delzescaux, Thierry, Déglon, Nicole, Beal, M Flint, Brouillet, Emmanuel

“…Huntington's disease (HD) is a neurodegenerative disorder caused by an abnormal expansion of a CAG repeat encoding a polyglutamine tract in the huntingtin…”
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Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity by Anglada-Huguet, Marta, Vidal, Laura, Giralt, Albert, García-Díaz Barriga, Gerardo, Xifró, Xavier, Alberch, Jordi

“…Abstract Huntington's disease (HD) patients and mouse models show learning and memory impairment even before the onset of motor symptoms. Deficits in…”
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