Search Results - "Alberati, Daniela"

Glycine Transporter Type I (GlyT1) Inhibitor, Bitopertin: A Journey from Lab to Patient by Pinard, Emmanuel, Borroni, Edilio, Koerner, Annette, Umbricht, Daniel, Alberati, Daniela

“…Glycine transporter-1 (GlyT1) inhibition has been extensively studied both in pharmaceutical companies and academic institutions primarily as a potential new…”
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Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia by Alberati, Daniela, Moreau, Jean-Luc, Lengyel, Judith, Hauser, Nicole, Mory, Roland, Borroni, Edilio, Pinard, Emmanuel, Knoflach, Frederic, Schlotterbeck, Götz, Hainzl, Dominik, Wettstein, Joseph G.

“…Dysfunctional N-methyl- d-aspartate (NMDA) receptor neurotransmission has been implicated in the pathophysiology of schizophrenia. It is thought that this…”
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Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia by Pinard, Emmanuel, Alanine, Alexander, Alberati, Daniela, Bender, Markus, Borroni, Edilio, Bourdeaux, Patrick, Brom, Virginie, Burner, Serge, Fischer, Holger, Hainzl, Dominik, Halm, Remy, Hauser, Nicole, Jolidon, Synese, Lengyel, Judith, Marty, Hans-Peter, Meyer, Thierry, Moreau, Jean-Luc, Mory, Roland, Narquizian, Robert, Nettekoven, Mathias, Norcross, Roger D, Puellmann, Bernd, Schmid, Philipp, Schmitt, Sebastien, Stalder, Henri, Wermuth, Roger, Wettstein, Joseph G, Zimmerli, Daniel

“…The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia. Herein, we report on the optimization of the…”
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Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal–lesioned rats: reversal by glycine and a glycine transporter inhibitor by Le Pen, Gwenaëlle, Kew, James, Alberati, Daniela, Borroni, Edilio, Heitz, Marie-Paule, Moreau, Jean-Luc

“…Neonatal ventral hippocampal (NVH) lesions in rats induce behavioral abnormalities at adulthood thought to simulate some aspects of the positive, negative, and…”
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Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression by Gabernet, Laetitia, Pauly-Evers, Meike, Schwerdel, Cornelia, Lentz, Michèle, Bluethmann, Horst, Vogt, Kaspar, Alberati, Daniela, Mohler, Hanns, Boison, Detlev

“…The occupation of the glycine binding-site is a prerequisite for NMDA receptor activation by glutamate. To analyze the regulation of NMDA receptor function by…”
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5:45 PM THE NEUROBIOLOGY OF NEGATIVE SYMPTOMS AND THE EFFECT OF GLYCINE REUPTAKE INHIBITORS by Alberati, Daniela

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A TRANSLATIONAL SUCCESS STORY: FACILITATING NMDA RECEPTOR SIGNALING WITH THE GLYCINE REUPTAKE INHIBITOR RG1678 by Alberati, Daniela

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Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study by Umbricht, Daniel, Alberati, Daniela, Martin-Facklam, Meret, Borroni, Edilio, Youssef, Eriene A, Ostland, Michael, Wallace, Tanya L, Knoflach, Frédéric, Dorflinger, Ernest, Wettstein, Joseph G, Bausch, Alexander, Garibaldi, George, Santarelli, Luca

“…In schizophrenia, the severity of negative symptoms is a key predictor of long-term disability. Deficient signaling through the N-methyl-D-aspartate receptor…”
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Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions by Yohn, Samantha E., Alberati, Daniela, Correa, Merce, Salamone, John D.

“…Rationale Motivated behavior can be characterized by a substantial exertion of effort, and organisms often make effort-related decisions based upon analyses of…”
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Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers by Hofmann, Carsten, Pizzagalli, Flavia, Boetsch, Christophe, Alberati, Daniela, Ereshefsky, Larry, Jhee, Stanford, Patat, Alain, Boutouyrie-Dumont, Bruno, Martin-Facklam, Meret

“…Rationale Hypofunction of NMDA receptors has been implicated in neuropsychiatric disorders including schizophrenia. NMDA receptor neurotransmission can be…”
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Effects of GlyT1 inhibition on erythropoiesis and iron homeostasis in rats by Winter, Michael, Funk, Jürgen, Körner, Annette, Alberati, Daniela, Christen, Francois, Schmitt, Georg, Altmann, Bernd, Pospischil, Andreas, Singer, Thomas

“…Glycine is a key rate-limiting component of heme biosynthesis in erythropoietic cells, where the high intracellular glycine demand is primarily supplied by the…”
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Preclinical Reproductive and Developmental Toxicity Profile of a Glycine Transporter Type 1 (Glyt1) Inhibitor by Barrow, Paul, Parrott, Neil, Alberati, Daniela, Paehler, Axel, Koerner, Annette

“…Bitopertin is a glycine type 1 (GlyT1) inhibitor intended for the treatment of psychiatric disorders. The principle adverse effect in the regulatory…”
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Physiologically Based Pharmacokinetic Modelling to Predict Single- and Multiple-Dose Human Pharmacokinetics of Bitopertin by Parrott, Neil, Hainzl, Dominik, Alberati, Daniela, Hofmann, Carsten, Robson, Richard, Boutouyrie, Bruno, Martin-Facklam, Meret

“…Background Bitopertin (RG1678) is a glycine reuptake inhibitor currently in phase 3 trials for treatment of schizophrenia. This paper describes the use of…”
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Evaluation of the Subjective Similarity of the GlyT1 Inhibitor Bitopertin to Five Drugs of Abuse Using Drug Discrimination Testing in the Rat by Dinklo, Theo, Gauvin, David, Järbe, Torbjörn, Gifford, Roger, Körner, Annette, Alberati, Daniela

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Alterations in High-Frequency Neuronal Oscillations in a Cynomolgus Macaque Test of Sustained Attention Following NMDA Receptor Antagonism by Goonawardena, Anushka V, Heiss, Jaime, Glavis-Bloom, Courtney, Trube, Gerhard, Borroni, Edilio, Alberati, Daniela, Wallace, Tanya L

“…A growing body of evidence indicates that neuronal oscillations in the gamma frequency range (30-80 Hz) are disturbed in schizophrenic patients during…”
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Pre-clinical characterization of [11C]R05013853 as a novel radiotracer for imaging of the glycine transporter type 1 by positron emission tomography by Borroni, Edilio, Zhou, Yun, Ostrowitzki, Susanne, Alberati, Daniela, Kumar, Anil, Hainzl, Dominik, Hartung, Thomas, Hilton, John, Dannals, Robert F., Wong, Dean F.

“…A specific positron emission tomography (PET) radiotracer for the glycine transporter type 1 (GlyT1) would constitute an imaging biomarker to investigate the…”
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Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential by Alberati, Daniela, Moreau, Jean-Luc, Mory, Roland, Pinard, Emmanuel, Wettstein, Joseph G.

“…Multiple lines of evidence support the notion that hypofunction of glutamatergic neurotransmission is involved in the pathophysiology of schizophrenia…”
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Regulation of the kynurenine metabolic pathway by interferon-gamma in murine cloned macrophages and microglial cells by Alberati-Giani, D, Ricciardi-Castagnoli, P, Köhler, C, Cesura, A M

“…Several pieces of evidence suggest a major role for brain macrophages in the overproduction of neuroactive kynurenines, including quinolinic acid, in brain…”
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[11C]-RO5013853: a New PET Radioligand for the Glycine Transporter TYPE 1 by Wong, Dean, Ostrowitzki, Susanne, Zhou, Yun, Alberati, Daniela, Pinard, Emmanuel, Raymont, Vanessa, Martin-facklam, Meret, Hofmann, Carsten, Parkar, Nikhat, Brasic, James, Hilton, John, Dannals, Robert, Borroni, Edilio

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Erratum: [11C]-RO5013853: a New PET Radioligand for the Glycine Transporter TYPE 1 by Wong, Dean, Ostrowitzki, Susanne, Zhou, Yun, Alberati, Daniela, Pinard, Emmanuel, Raymont, Vanessa, Martin-Facklam, Meret, Hofmann, Carsten, Parkar, Nikhat, Brasic, James, Hilton, John, Dannals, Robert, Borroni, Edilio

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