Anterior thalamic nuclei lesions in rats disrupt markers of neural plasticity in distal limbic brain regions

Highlights ► Anterior thalamic lesions alter the ratio of hippocampal CREB to pCREB. ► Anterior thalamic lesions reduced pCREB in granular retrosplenial cortex. ► Changes in limbic pCREB may explain learning deficits after anterior thalamic lesions. ► zif268 Hypoactivity in granular retrosplenial co...

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Published in:	Neuroscience Vol. 224; no. 2; pp. 81 - 101
Main Authors:	Dumont, J.R, Amin, E, Poirier, G.L, Albasser, M.M, Aggleton, J.P
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 08-11-2012 Elsevier Elsevier Science
Subjects:	Animals Anterior Thalamic Nuclei - injuries Anterior Thalamic Nuclei - metabolism Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors CREB Cyclic AMP Response Element-Binding Protein - metabolism Fundamental and applied biological sciences. Psychology GAP-43 Genes, Immediate-Early - physiology hippocampus Immunohistochemistry Limbic System - metabolism Male Neural Pathways - metabolism Neurology Neuronal Plasticity - physiology phosphorylated CREB Rats retrosplenial cortex Vertebrates: nervous system and sense organs zif268 prelimbic cortex pSub Prh temporal CA3 PFA temporal CA1 N-methyl- d-aspartic acid mEnt BSA caudal dysgranular retrosplenial cortex dSub anterior thalamic lesion tCA3 rRdg GAP-43 PBS containing 0.2% Triton X-100 rostral granular retrosplenial cortex, area b PBS IL IEG primary auditory cortex iDG lateral entorhinal cortex intermediate dentate gyrus phosphorylated CREB Hpc iCA1 cRdg iCA3 medial entorhinal cortex bovine serum albumin 4% paraformaldehyde in 0.1 M PBS cRgb infralimbic cortex cRga intermediate CA3 intermediate CA1 rRgb growth associated protein43 CREB tCA caudal granular retrosplenial cortex, area a postsubiculum caudal granular retrosplenial cortex, area b NMDA zif268 immediate early gene diaminobenzidine lEnto DAB hippocampus phosphate buffer saline c-AMP response element binding protein perirhinal cortex pCREB PBST dorsal subiculum rostral dysgranular retrosplenial cortex ATN PL Audp retrosplenial cortex Phosphorylation Growth associated protein 43 Rat Rodentia Central nervous system Encephalon Vertebrata Mammalia Animal EGR1 transcription factor Plasticity Thalamus Lesion Transcription factor CREB Hippocampus
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Summary:	Highlights ► Anterior thalamic lesions alter the ratio of hippocampal CREB to pCREB. ► Anterior thalamic lesions reduced pCREB in granular retrosplenial cortex. ► Changes in limbic pCREB may explain learning deficits after anterior thalamic lesions. ► zif268 Hypoactivity in granular retrosplenial cortex after anterior thalamic lesions. ► Hippocampal zif268 levels relatively insensitive to anterior thalamic damage.
Bibliography:	Present address: École Polytechnique Fédérale de Lausanne, Brain Mind Institute, Laboratory of Behavioral Genetics, CH-1015 Lausanne, Switzerland.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.08.027