Search Results - "Alba, Lorena"

Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis by Alba-Castellón, Lorena, Olivera-Salguero, Rubén, Mestre-Farrera, Aida, Peña, Raúl, Herrera, Mercedes, Bonilla, Félix, Casal, J Ignacio, Baulida, Josep, Peña, Cristina, García de Herreros, Antonio

“…Snail1 transcriptional factor is essential for triggering epithelial-to-mesenchymal transition (EMT) and inducing tumor cell invasion. We report here an…”
Get full text

CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma by Rioja-Blanco, Elisa, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Gallardo, Alberto, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, León, Xavier, Alba-Castellón, Lorena, Mangues, Ramon

“…Therapy resistance, which leads to the development of loco-regional relapses and distant metastases after treatment, constitutes one of the major problems that…”
Get full text

Probiotic Consumption Boosts Thymus in Obesity and Senescence Mouse Models by Balcells, Florencia, Martínez Monteros, María José, Gómez, Alba Lorena, Cazorla, Silvia Inés, Perdigón, Gabriela, Maldonado-Galdeano, Carolina

“…The ability of the immune system to respond to different pathogens throughout life requires the constant production and selection of T cells in the thymus…”
Get full text

Multivesicular GSK3 Sequestration upon Wnt Signaling Is Controlled by p120-Catenin/Cadherin Interaction with LRP5/6 by Vinyoles, Meritxell, Del Valle-Pérez, Beatriz, Curto, Josué, Viñas-Castells, Rosa, Alba-Castellón, Lorena, García de Herreros, Antonio, Duñach, Mireia

“…The Wnt canonical ligands elicit the activation of β-catenin transcriptional activity, a response dependent on, but not limited to, β-catenin stabilization…”
Get full text

Altitude and community traits explain rain forest stand dynamics over a 2370‐m altitudinal gradient in Costa Rica by Hernández Gordillo, Alba Lorena, Vilchez Mendoza, Sergio, Ngo Bieng, Marie Ange, Delgado, Diego, Finegan, Bryan

“…Stand dynamic rates in Earth's vitally important tropical mountain rain forests are a central component of the response of these forests to global change, but…”
Get full text

GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases by Sala, Rita, Rioja-Blanco, Elisa, Serna, Naroa, Sánchez-García, Laura, Álamo, Patricia, Alba-Castellón, Lorena, Casanova, Isolda, López-Pousa, Antonio, Unzueta, Ugutz, Céspedes, María Virtudes, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon

“…Colorectal cancer (CRC) remains the third cause of cancer-related mortality in Western countries, metastases are the main cause of death. CRC treatment remains…”
Get full text

Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles by Martínez-Torró, Carlos, Alba-Castellón, Lorena, Carrasco-Díaz, Luis Miguel, Serna, Naroa, Imedio, Laura, Gallardo, Alberto, Casanova, Isolda, Unzueta, Ugutz, Vázquez, Esther, Mangues, Ramón, Villaverde, Antonio

“…Two human proteins involved in the inflammatory cell death, namely Gasdermin D (GSDMD) and the Mixed Lineage Kinase Domain-Like (MLKL) protein have been…”
Get full text

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination by Pallarès, Victor, Unzueta, Ugutz, Falgàs, Aïda, Sánchez-García, Laura, Serna, Naroa, Gallardo, Alberto, Morris, Gordon A, Alba-Castellón, Lorena, Álamo, Patricia, Sierra, Jorge, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon

“…Current acute myeloid leukemia (AML) therapy fails to eliminate quiescent leukemic blasts in the bone marrow, leading to about 50% of patient relapse by…”
Get full text

Multi-dimensional temperature sensitivity of protected tropical mountain rain forests by Finegan, Bryan, Delgado, Diego, Hernández Gordillo, Alba Lorena, Zamora Villalobos, Nelson, Núñez Florez, Rafael, Díaz Santos, Fabio, Vílchez Mendoza, Sergio

“…Introduction Tropical mountain rain forests (TMRF, natural forests at > 300 m asl) are globally important for biodiversity and ecosystem services and are…”
Get full text

A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice by Falgàs, Aïda, Garcia-León, Annabel, Núñez, Yáiza, Serna, Naroa, Sánchez-Garcia, Laura, Unzueta, Ugutz, Voltà-Durán, Eric, Aragó, Marc, Álamo, Patricia, Alba-Castellón, Lorena, Sierra, Jorge, Gallardo, Alberto, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Casanova, Isolda

“…High rates of relapsed and refractory diffuse large B-cell lymphoma (DLBCL) patients and life-threatening side effects associated with immunochemotherapy make…”
Get full text

Protumorigenic effects of Snail‐expression fibroblasts on colon cancer cells by Herrera, Alberto, Herrera, Mercedes, Alba‐Castellón, Lorena, Silva, Javier, García, Vanesa, Loubat‐Casanovas, Jordina, Álvarez‐Cienfuegos, Ana, Miguel García, José, Rodriguez, Rufo, Gil, Beatriz, Ma Jesús Citores, Ma Jesús Larriba, Ignacio Casal, J., Herreros, Antonio García, Bonilla, Félix, Peña, Cristina

“…Snail1 is a transcriptional factor that plays an important role in epithelial–mesenchymal transition and in the acquisition of invasive properties by…”
Get full text

Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors by Rioja-Blanco, Elisa, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Gallardo, Alberto, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Alba-Castellón, Lorena, León, Xavier

“…Loco-regional recurrences and distant metastases represent the main cause of head and neck squamous cell carcinoma (HNSCC) mortality. The overexpression of…”
Get full text

A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model by Rioja-Blanco, Elisa, Gallardo, Alberto, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, León, Xavier, Alba-Castellón, Lorena, Mangues, Ramon

“…Loco-regional recurrences and metastasis represent the leading causes of death in head and neck squamous cell carcinoma (HNSCC) patients, highlighting the need…”
Get full text

CXCR4 Expression as a Prognostic Biomarker in Soft Tissue Sarcomas by Virgili, Anna C, Salazar, Juliana, Gallardo, Alberto, López-Pousa, Antonio, Terés, Raúl, Bagué, Silvia, Orellana, Ruth, Fumagalli, Caterina, Mangues, Ramon, Alba-Castellón, Lorena, Unzueta, Ugutz, Casanova, Isolda, Sebio, Ana

“…Poor long-term survival in localized high-risk soft tissue sarcomas (STSs) of the extremities and trunk highlights the need to identify new prognostic factors…”
Get full text

Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease by Medina-Gutiérrez, Esperanza, Céspedes, María Virtudes, Gallardo, Alberto, Rioja-Blanco, Elisa, Pavón, Miquel Àngel, Asensio-Puig, Laura, Farré, Lourdes, Alba-Castellón, Lorena, Unzueta, Ugutz, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon

“…Advanced endometrial cancer (EC) lacks therapy, thus, there is a need for novel treatment targets. CXCR4 overexpression is associated with a poor prognosis in…”
Get full text

Snail1 Expression Is Required for Sarcomagenesis by Alba-Castellón, Lorena, Batlle, Raquel, Francí, Clara, Fernández-Aceñero, María J, Mazzolini, Rocco, Peña, Raúl, Loubat, Jordina, Alameda, Francesc, Rodríguez, Rufo, Curto, Josué, Albanell, Joan, Muñoz, Alberto, Bonilla, Félix, Ignacio Casal, J, Rojo, Federico, García de Herreros, Antonio

“…Abstract Snail1 transcriptional repressor is a major inducer of epithelial-to mesenchymal transition but is very limitedly expressed in adult animals. We have…”
Get full text

Keratinocyte-targeted overexpression of the glucocorticoid receptor delays cutaneous wound healing by Sanchis, Ana, Alba, Lorena, Latorre, Víctor, Sevilla, Lisa M, Pérez, Paloma

“…Delayed wound healing is one of the most common secondary adverse effects associated to the therapeutic use of glucocorticoid (GC) analogs, which act through…”
Get full text

Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion by Murray, Elizabeth R., Menezes, Shinelle, Henry, Jack C., Williams, Josie L., Alba-Castellón, Lorena, Baskaran, Priththivika, Quétier, Ivan, Desai, Ami, Marshall, Jacqueline J.T., Rosewell, Ian, Tatari, Marianthi, Rajeeve, Vinothini, Khan, Faraz, Wang, Jun, Kotantaki, Panoraia, Tyler, Eleanor J., Singh, Namrata, Reader, Claire S., Carter, Edward P., Hodivala-Dilke, Kairbaan, Grose, Richard P., Kocher, Hemant M., Gavara, Nuria, Pearce, Oliver, Cutillas, Pedro, Marshall, John F., Cameron, Angus J.M.

“…In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs)…”
Get full text

Preoperative dexamethasone reduces postoperative pain, nausea and vomiting following mastectomy for breast cancer by Gómez-Hernández, Jorge, Orozco-Alatorre, Alba Lorena, Domínguez-Contreras, Marisela, Oceguera-Villanueva, Antonio, Gómez-Romo, Salvador, Alvarez Villaseñor, Andrea Socorro, Fuentes-Orozco, Clotilde, González-Ojeda, Alejandro

“…Dexamethasone has been reported to reduce postoperative symptoms after different surgical procedures. We evaluated the efficacy of preoperative dexamethasone…”
Get full text

Desigualdad de resultados pruebas Saber-11 antes y durante la pandemia covid-19 (2014-2021) by Ballesteros Alfonso, Alba Lorena, Gómez Velasco, Nubia Yaneth

“…(analítico)Se realizó un análisis descriptivo de la desigualdad en los resultados de las pruebas Saber-11 en el periodo 2014-2021 del departamento de Boyacá,…”
Get full text