Search Results - "Alba, Grace"

Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3 by Li, Zhihong, Wang, Xianghong, Eksterowicz, John, Gribble, Michael W, Alba, Grace Q, Ayres, Merrill, Carlson, Timothy J, Chen, Ada, Chen, Xiaoqi, Cho, Robert, Connors, Richard V, DeGraffenreid, Michael, Deignan, Jeffrey T, Duquette, Jason, Fan, Pingchen, Fisher, Benjamin, Fu, Jiasheng, Huard, Justin N, Kaizerman, Jacob, Keegan, Kathleen S, Li, Cong, Li, Kexue, Li, Yunxiao, Liang, Lingming, Liu, Wen, Lively, Sarah E, Lo, Mei-Chu, Ma, Ji, McMinn, Dustin L, Mihalic, Jeffrey T, Modi, Kriti, Ngo, Rachel, Pattabiraman, Kanaka, Piper, Derek E, Queva, Christophe, Ragains, Mark L, Suchomel, Julia, Thibault, Steve, Walker, Nigel, Wang, Xiaodong, Wang, Zhulun, Wanska, Malgorzata, Wehn, Paul M, Weidner, Margaret F, Zhang, Alex J, Zhao, Xiaoning, Kamb, Alexander, Wickramasinghe, Dineli, Dai, Kang, McGee, Lawrence R, Medina, Julio C

“…We describe the structural optimization of a lead compound 1 that exhibits dual inhibitory activities against FLT3 and CDK4. A series of…”
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Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia by Keegan, Kathleen, Li, Cong, Li, Zhihong, Ma, Ji, Ragains, Mark, Coberly, Suzanne, Hollenback, David, Eksterowicz, John, Liang, Lingming, Weidner, Margaret, Huard, Justin, Wang, Xianghong, Alba, Grace, Orf, Jessica, Lo, Mei-Chu, Zhao, Sharon, Ngo, Rachel, Chen, Ada, Liu, Lily, Carlson, Timothy, Quéva, Christophe, McGee, Lawrence R, Medina, Julio, Kamb, Alexander, Wickramasinghe, Dineli, Dai, Kang

“…Acute myeloid leukemia (AML) remains a serious unmet medical need. Despite high remission rates with chemotherapy standard-of-care treatment, the disease…”
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Abstract A279: Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor by Dai, Kang, Keegan, Kathleen, Li, Zhihong, Ji, Ma, Li, Cong, Eksterowicz, John, Suzanne, Coberly, Hollenback, David, Weidner, Margret, Huard, Justin, Liang, Lingming, Alba, Grace, Orf, Jessica, Lo, Mei-Chu, Zhao, Sharon, Ngo, Rachel, Chen, Ada, Liu, Lily, Carlson, Timothy, McGee, Lawrence R., Medina, Julio, Kamb, Alexander, Wickramasinghe, Dineli

“…Abstract Acute myeloid leukemia (AML) remains a serious unmet medical need. Despite high remission rates with chemotherapy standard care treatment, the disease…”
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Abstract 2351: CDK4/FLT3 dual inhibitors as potential therapeutics for acute myeloid leukemia by Li, Zhihong, Dai, Kang, Keegan, Kathleen, Ma, Ji, Ragains, Mark, Kaizerman, Jacob, McMinn, Dustin, Fu, Jiasheng, Fisher, Benjamin, Gribble, Michael, McGee, Lawrence R., Eksterowicz, John, Li, Cong, Liang, Lingming, Weidner, Margaret, Huard, Justin, Cho, Robert, Carlson, Timothy, Alba, Grace M., Hollenback, David, Hill, John, Beaupre, Darrin, Kamb, Alexander, Wickramasinghe, Dineli, Medina, Julio C.

“…Abstract CDK4 is a cyclin D dependent kinase that promotes cell cycle progression in a broad range of tumor types by phosphorylating the tumor suppressor…”
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