The relations of circulating agouti-related peptide and leptin with altered sleep architecture in patients with active Cushing’s disease: a pilot study
Aim To evaluate sleep architecture of patients with Cushing’s disease (CD) and to explore whether agouti-related peptide (AgRP) and/or leptin play a permissive role in sleep alterations in patients with active CD. Methods We performed polysomnography on 26 patients with active CD and age 26 age- and...
Saved in:
| Published in: | Journal of endocrinological investigation Vol. 47; no. 1; pp. 167 - 178 |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Cham
Springer International Publishing
01-01-2024
Springer Nature B.V |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Aim
To evaluate sleep architecture of patients with Cushing’s disease (CD) and to explore whether agouti-related peptide (AgRP) and/or leptin play a permissive role in sleep alterations in patients with active CD.
Methods
We performed polysomnography on 26 patients with active CD and age 26 age- and sex-matched control subjects. Blood samples were obtained from all participants for the analyzes of AgRP and leptin. The laboratory and sleep-related parameters were compared.
Results
The groups were similar in age, gender, and body mass index. The CD group had reduced sleep efficiency (71.6 ± 12.1% vs. 78.8 ± 12.6%,
p
= 0.042) and increased wake after sleep onset (WASO%) (24.7 ± 13.1% vs. 17.4 ± 11.6%,
p
= 0.040) as compared to control group. Seventeen patients with CD (65.4%) and 18 control subjects (69.2%) had obstructive sleep apnea. Serum AgRP (13.2 ± 7.4 pg/ml vs. 9 ± 3.1,
p
= 0.029), leptin (59.5 mcg/l, [IQR] 32.6–94.6 vs. 25.3 mcg/l, [IQR] 12.9–57.5,
p
= 0.007) were higher in CD group. AgRP and leptin correlated negatively with total sleep time, sleep efficiency, stage N2 sleep (%), and positively with WASO%. In multiple regression analyses, serum cortisol (
ß
= − 0.359,
p
= 0.042) and AgRP (
ß
= − 0.481,
p
= 0.01) were significant predictor of sleep efficiency. AgRP was also significant predictor of WASO% (
ß
= 0.452 and p < 0.05).
Conclusions
Active CD carries an increased risk of impaired sleep efficiency and continuity which may worsen health-related quality of life. Elevated circulating AgRP and, to a lesser extent, leptin may be associated with decreased sleep efficiency and continuity in patients with CD. Patients with CD who have subjective sleep symptoms should be screened with polysomnography. |
|---|---|
| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1720-8386 0391-4097 1720-8386 |
| DOI: | 10.1007/s40618-023-02133-0 |