Search Results - "Alayash, Abdu I."

Mechanisms of Toxicity and Modulation of Hemoglobin-based Oxygen Carriers by Alayash, Abdu I

“…ABSTRACTSeveral adverse events have been associated with the infusion of hemoglobin-based oxygen carriers (HBOCs), including transient hypertension,…”
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Blood substitutes: why haven’t we been more successful? by Alayash, Abdu I

“…Highlights • HBOC therapeutics are intended to correct oxygen deficit. • Safety concerns slowed the development of these life-saving products. • Evidence is…”
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βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease by Alayash, Abdu I.

“…βcysteine 93 residue plays a key role in oxygen (O2)-linked conformational changes in the hemoglobin (Hb) molecule. This solvent accessible residue is also a…”
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Targeting the red cell enzyme pyruvate kinase with a small allosteric molecule AG-348 may correct underlying pathology of a glycolytic enzymopathy by Alayash, Abdu I

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Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease by Belcher, John D., Chen, Chunsheng, Nguyen, Julia, Milbauer, Liming, Abdulla, Fuad, Alayash, Abdu I., Smith, Ann, Nath, Karl A., Hebbel, Robert P., Vercellotti, Gregory M.

“…Treatment of sickle cell disease (SCD) is hampered by incomplete understanding of pathways linking hemolysis to vaso-occlusion. We investigated these pathways…”
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Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins by Schaer, Dominik J., Buehler, Paul W., Alayash, Abdu I., Belcher, John D., Vercellotti, Gregory M.

“…Hemolysis occurs in many hematologic and nonhematologic diseases. Extracellular hemoglobin (Hb) has been found to trigger specific pathophysiologies that are…”
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The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular Perspective by Alayash, Abdu I.

“…The novel coronavirus (2019-nCoV/SARS-CoV-2) causes respiratory symptoms including a substantial pulmonary dysfunction with worsening arterial hypoxemia (low…”
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Oxidation reactions of cellular and acellular hemoglobins: Implications for human health by Alayash, Abdu I

“…Oxygen reversibly binds to the redox active iron, a transition metal in human Hemoglobin (Hb), which subsequently undergoes oxidation in air. This process is…”
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Cell-Free Hemoglobin Does Not Attenuate the Effects of SARS-CoV-2 Spike Protein S1 Subunit in Pulmonary Endothelial Cells by Jana, Sirsendu, Heaven, Michael R., Alayash, Abdu I.

“…SARS-CoV-2 primarily infects epithelial airway cells that express the host entry receptor angiotensin-converting enzyme 2 (ACE2), which binds to the S1 spike…”
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Post-translational modification as a response to cellular stress induced by hemoglobin oxidation in sickle cell disease by Strader, Michael Brad, Jana, Sirsendu, Meng, Fantao, Heaven, Michael R., Shet, Arun S., Thein, Swee Lay, Alayash, Abdu I.

“…Intracellular oxidative stress and oxidative modification of sickle hemoglobin (HbS) play a role in sickle cell disease (SCD) pathogenesis. Recently, we…”
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The Providence Mutation (βK82D) in Human Hemoglobin Substantially Reduces βCysteine 93 Oxidation and Oxidative Stress in Endothelial Cells by Jana, Sirsendu, Strader, Michael Brad, Alayash, Abdu I

“…The highly toxic oxidative transformation of hemoglobin (Hb) to the ferryl state (HbFe ) is known to occur in both in vitro and in vivo settings. We recently…”
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Impact of cold storage on the oxygenation and oxidation reactions of red blood cells by Kassa, Tigist, Jana, Sirsendu, Baek, Jin Hyen, Alayash, Abdu I

“…Electrostatic binding of deoxyhemoglobin (Hb) to cytoplasmic domain of band 3 anion transport protein occurs as part of the glycolytic regulation in red blood…”
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HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected Hamsters by Jana, Sirsendu, Heaven, Michael R, Stauft, Charles B, Wang, Tony T, Williams, Matthew C, D'Agnillo, Felice, Alayash, Abdu I

“…The mechanistic interplay between SARS-CoV-2 infection, inflammation, and oxygen homeostasis is not well defined. Here, we show that the hypoxia-inducible…”
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Hemoglobin Oxidation Reactions in Stored Blood by Alayash, Abdu I

“…Hemoglobin (Hb) inside and outside the red blood cells (RBCs) undergoes constant transformation to an oxidized form in a process known as autoxidation. The…”
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Changes in hemoglobin oxidation and band 3 during blood storage impact oxygen sensing and mitochondrial bioenergetic pathways in the human pulmonary arterial endothelial cell model by Jana, Sirsendu, Kassa, Tigist, Wood, Francine, Hicks, Wayne, Alayash, Abdu I.

“…Red blood cells (RBCs) undergo metabolic, oxidative, and physiological changes during storage, collectively described as the “storage lesion.” The impact of…”
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Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help? by Alayash, Abdu I

“…Intense efforts have been made by both industry and academia over the last three decades to produce viable hemoglobin (Hb)-based oxygen carriers (HBOCs), also…”
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Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase‐1 by Kassa, Tigist, Jana, Sirsendu, Meng, Fantao, Alayash, Abdu I.

“…Despite advances in our understanding of the oxidative pathways mediated by free hemoglobin (Hb), the precise contribution of its highly reactive redox forms…”
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Antisickling Drugs Targeting βCys93 Reduce Iron Oxidation and Oxidative Changes in Sickle Cell Hemoglobin by Kassa, Tigist, Wood, Francine, Strader, Michael Brad, Alayash, Abdu I

“…Sickle cell disease is a genetic blood disorder caused by a single point mutation in the β globin gene where glutamic acid is replaced by valine at the sixth…”
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Molecular controls of the oxygenation and redox reactions of hemoglobin by Bonaventura, Celia, Henkens, Robert, Alayash, Abdu I, Banerjee, Sambuddha, Crumbliss, Alvin L

“…The broad classes of O(2)-binding proteins known as hemoglobins (Hbs) carry out oxygenation and redox functions that allow organisms with significantly…”
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Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification by Buehler, Paul W., Abraham, Bindu, Vallelian, Florence, Linnemayr, Charlotte, Pereira, Claudia P., Cipollo, John F., Jia, Yiping, Mikolajczyk, Malgorzata, Boretti, Felicitas S., Schoedon, Gabriele, Alayash, Abdu I., Schaer, Dominik J.

“…Detoxification and clearance of extracellular hemoglobin (Hb) have been attributed to its removal by the CD163 scavenger receptor pathway. However, even…”
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