Search Results - "Alastrue, Ana"
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A Hyaluronic Acid Demilune Scaffold and Polypyrrole-Coated Fibers Carrying Embedded Human Neural Precursor Cells and Curcumin for Surface Capping of Spinal Cord Injuries
Published in Biomedicines (16-12-2021)“…Tissue engineering, including cell transplantation and the application of biomaterials and bioactive molecules, represents a promising approach for…”
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Biohybrids for spinal cord injury repair
Published in Journal of tissue engineering and regenerative medicine (01-03-2019)“…Spinal cord injuries (SCIs) result in the loss of sensory and motor function with massive cell death and axon degeneration. We have previously shown that…”
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FM19G11 Favors Spinal Cord Injury Regeneration and Stem Cell Self-Renewal by Mitochondrial Uncoupling and Glucose Metabolism Induction
Published in Stem cells (Dayton, Ohio) (01-10-2012)“…Spinal cord injury is a major cause of paralysis with no currently effective therapies. Induction of self‐renewal and proliferation of endogenous regenerative…”
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Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment
Published in International journal of molecular sciences (31-05-2021)“…We currently lack effective treatments for the devastating loss of neural function associated with spinal cord injury (SCI). In this study, we evaluated a…”
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tappAS: a comprehensive computational framework for the analysis of the functional impact of differential splicing
Published in Genome Biology (18-05-2020)“…Recent advances in long-read sequencing solve inaccuracies in alternative transcript identification of full-length transcripts in short-read RNA-Seq data,…”
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Transplantation of Human-Fetal-Spinal-Cord-Derived NPCs Primed with a Polyglutamate-Conjugated Rho/Rock Inhibitor in Acute Spinal Cord Injury
Published in Cells (Basel, Switzerland) (01-10-2022)“…Neural precursor cell (NPC) transplantation represents a promising therapy for treating spinal cord injuries (SCIs); however, despite successful results…”
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Purinergic Receptors in Spinal Cord-Derived Ependymal Stem/Progenitor Cells and Their Potential Role in Cell-Based Therapy for Spinal Cord Injury
Published in Cell transplantation (01-08-2015)“…Spinal cord injury (SCI) is a major cause of paralysis with no current therapies. Following SCI, large amounts of ATP and other nucleotides are released by the…”
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FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury
Published in International journal of molecular sciences (09-01-2018)“…Spinal cord injury (SCI) suffers from a lack of effective therapeutic strategies. We have previously shown that individual therapeutic strategies,…”
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Acute transplantation of NPC on electrospun poly-lactic acid membranes containing curcumin into the injured spinal cord reduces neuronal degeneration
Published in Frontiers in biomaterials science (13-11-2023)“…Effective spinal cord injury (SCI) treatment remains a significant challenge, given the complex nature of the primary injury and associated devastating loss of…”
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Human Suprapatellar Fat Pad-Derived Mesenchymal Stem Cells Induce Chondrogenesis and Cartilage Repair in a Model of Severe Osteoarthritis
Published in Stem cells international (01-01-2017)“…Cartilage degeneration is associated with degenerative bone and joint processes in severe osteoarthritis (OA). Spontaneous cartilage regeneration is extremely…”
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Connexin 50 Expression in Ependymal Stem Progenitor Cells after Spinal Cord Injury Activation
Published in International journal of molecular sciences (06-11-2015)“…Ion channels included in the family of Connexins (Cx) help to control cell proliferation and differentiation of neuronal progenitors. Here we explored the role…”
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Methacrylate-endcapped caprolactone and FM19G11 provide a proper niche for spinal cord-derived neural cells
Published in Journal of tissue engineering and regenerative medicine (01-06-2015)“…Spinal cord injury (SCI) is a cause of paralysis. Although some strategies have been proposed to palliate the severity of this condition, so far no effective…”
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Connexin 50 modulates Sox2 expression in spinal-cord-derived ependymal stem/progenitor cells
Published in Cell and tissue research (01-08-2016)“…Ion channels included in the family of Connexins (Cx) have been reported to influence the secondary expansion of traumatic spinal cord injury (SCI) and…”
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Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery
Published in Biomaterials (01-01-2017)“…Abstract Spinal cord injury (SCI) suffers from a lack of effective therapeutic strategies. Animal models of acute SCI have provided evidence that…”
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NPC transplantation rescues sci-driven cAMP/EPAC2 alterations, leading to neuroprotection and microglial modulation
Published in Cellular and molecular life sciences : CMLS (01-08-2022)“…Neural progenitor cell (NPC) transplantation represents a promising treatment strategy for spinal cord injury (SCI); however, the underlying therapeutic…”
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Human adipose-derived mesenchymal stem cells accelerate decellularized neobladder regeneration
Published in Regenerative biomaterials (01-03-2020)“…Abstract Decellularized natural bladder matrices (neobladders) represent an exciting means to regenerate the bladder following bladder cancer-associated…”
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Experimental cell transplantation for traumatic spinal cord injury regeneration: intramedullar or intrathecal administration
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2014)“…Animal experimentation models are a necessary prerequisite to human trials for the use of regenerative medicine in the treatment of spinal cord injuries…”
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Histologically Invaded Intramammary Sentinel Node, but no Metastases found on Axillary Dissection
Published in The European journal of surgery (26-10-1999)Get full text
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