Search Results - "Alas, Germain C M"

Encystation stimuli sensing is mediated by adenylate cyclase AC2-dependent cAMP signaling in Giardia by Shih, Han-Wei, Alas, Germain C. M., Paredez, Alexander R.

“…Protozoan parasites use cAMP signaling to precisely regulate the place and time of developmental differentiation, yet it is unclear how this signaling is…”
Get full text

The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment by Hardin, William R, Alas, Germain C M, Taparia, Nikita, Thomas, Elizabeth B, Steele-Ogus, Melissa C, Hvorecny, Kelli L, Halpern, Aaron R, Tůmová, Pavla, Kollman, Justin M, Vaughan, Joshua C, Sniadecki, Nathan J, Paredez, Alexander R

“…Attachment to the intestinal epithelium is critical to the lifestyle of the ubiquitous parasite Giardia lamblia. The ventrolateral flange is a sheet-like…”
Get full text

Identification and Validation of Small-Gatekeeper Kinases as Drug Targets in Giardia lamblia by Hennessey, Kelly M, Smith, Tess R, Xu, Jennifer W, Alas, Germain C M, Ojo, Kayode K, Merritt, Ethan A, Paredez, Alexander R

“…Giardiasis is widely acknowledged to be a neglected disease in need of new therapeutics to address toxicity and resistance issues associated with the limited…”
Get full text

Hybrid Structured Illumination Expansion Microscopy Reveals Microbial Cytoskeleton Organization by Halpern, Aaron R, Alas, Germain C. M, Chozinski, Tyler J, Paredez, Alexander R, Vaughan, Joshua C

“…Recently developed tissue-hydrogel methods for specimen expansion now enable researchers to perform super-resolution microscopy with ∼65 nm lateral resolution…”
Get full text

Rac Regulates Giardia lamblia Encystation by Coordinating Cyst Wall Protein Trafficking and Secretion by Krtková, Jana, Thomas, Elizabeth B, Alas, Germain C M, Schraner, Elisabeth M, Behjatnia, Habib R, Hehl, Adrian B, Paredez, Alexander R

“…Encystation of the common intestinal parasite Giardia lamblia involves the production, trafficking, and secretion of cyst wall material (CWM). However, the…”
Get full text

Staging Encystation Progression in Giardia lamblia Using Encystation-Specific Vesicle Morphology and Associating Molecular Markers by Thomas, Elizabeth B, Sutanto, Renaldo, Johnson, Richard S, Shih, Han-Wei, Alas, Germain C M, Krtková, Jana, MacCoss, Michael J, Paredez, Alexander R

“…Differentiation into environmentally resistant cysts is required for transmission of the ubiquitous intestinal parasite . Encystation in requires the…”
Get full text

14-3-3 Regulates Actin Filament Formation in the Deep-Branching Eukaryote Giardia lamblia by Krtková, Jana, Xu, Jennifer, Lalle, Marco, Steele-Ogus, Melissa, Alas, Germain C M, Sept, David, Paredez, Alexander R

“…The phosphoserine/phosphothreonine-binding protein 14-3-3 is known to regulate actin; this function has been previously attributed to sequestration of…”
Get full text

A cell-cycle-dependent GARP-like transcriptional repressor regulates the initiation of differentiation in Giardia lamblia by Shih, Han-Wei, Alas, Germain C M, Paredez, Alexander R

“…Transcriptional regulation of differentiation is critical for parasitic pathogens to adapt to environmental changes and regulate transmission. In response to…”
Get full text

Myosin-independent cytokinesis in Giardia utilizes flagella to coordinate force generation and direct membrane trafficking by Hardin, William R., Li, Renyu, Xu, Jason, Shelton, Andrew M., Alas, Germain C. M., Minin, Vladimir N., Paredez, Alexander R.

“…Devoid of all known canonical actin-binding proteins, the prevalent parasite Giardia lamblia uses an alternative mechanism for cytokinesis. Unique aspects of…”
Get full text

Nek8445, a protein kinase required for microtubule regulation and cytokinesis in Giardia lamblia by Hennessey, Kelly M, Alas, Germain C M, Rogiers, Ilse, Li, Renyu, Merritt, Ethan A, Paredez, Alexander R

“…has 198 Nek kinases whereas humans have only 11. has a complex microtubule cytoskeleton that includes eight flagella and several unique microtubule arrays that…”
Get full text

Unraveling the role of cAMP signaling in Giardia : insights into PKA-mediated regulation of encystation and subcellular interactions by Shih, Han-Wei, Alas, Germain C M, Paredez, Alexander R

“…cAMP plays an important role as a second messenger in the stage transition of various protozoan parasites. This signaling pathway relies on multiple effectors,…”
Get full text

14-3-3 Regulates Actin Filament Formation in the Deep-Branching Eukaryote Giardia lamblia by Krtková, Jana, Xu, Jennifer, Lalle, Marco, Steele-Ogus, Melissa, Alas, Germain C. M., Sept, David, Paredez, Alexander R.

“…Giardia lacks canonical actin-binding proteins. Gl-14-3-3 was identified as an actin interactor, but the significance of this interaction was unknown. Loss of…”
Get full text