Search Results - "Alarcón‐Riquelme, Marta"

The genetic basis of systemic lupus erythematosus: What are the risk factors and what have we learned by Teruel, Maria, Alarcón-Riquelme, Marta E

“…Abstract The genome-wide association study is a free-hypothesis approach based on screening of thousands or even millions of genetic variants distributed…”
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Gene Expression and Pharmacodynamic Changes in 1,760 Systemic Lupus Erythematosus Patients From Two Phase III Trials of BAFF Blockade With Tabalumab by Hoffman, Robert W., Merrill, Joan T., Alarcón‐Riquelme, Marta M. E., Petri, Michelle, Dow, Ernst R., Nantz, Eric, Nisenbaum, Laura K., Schroeder, Krista M., Komocsar, Wendy J., Perumal, Narayanan B., Linnik, Matthew D., Airey, David C., Liu, Yushi, Rocha, Guilherme V., Higgs, Richard E.

“…Objective To characterize baseline gene expression and pharmacodynamically induced changes in whole blood gene expression in 1,760 systemic lupus erythematosus…”
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Genes, epigenetic regulation and environmental factors: Which is the most relevant in developing autoimmune diseases? by Costenbader, Karen H, Gay, Steffen, Alarcón-Riquelme, Marta E, Iaccarino, Luca, Doria, Andrea

“…Abstract Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and inflammatory bowel disease, have complex…”
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Machine Learning for the Identification of a Common Signature for Anti–SSA/Ro 60 Antibody Expression Across Autoimmune Diseases by Foulquier, Nathan, Le Dantec, Christelle, Bettacchioli, Eleonore, Jamin, Christophe, Alarcón‐Riquelme, Marta E., Pers, Jacques‐Olivier

“…Objective Anti‐Ro autoantibodies are among the most frequently detected extractable nuclear antigen autoantibodies, mainly associated with primary Sjögren's…”
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A basket genetic trial of the vasculitides by Carnero-Montoro, Elena, Alarcón-Riquelme, Marta E.

“…The rarity of various forms of vasculitis, as well as other rheumatic diseases, presents difficulties in studying the genetics of these diseases as well as for…”
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ImaGEO: integrative gene expression meta-analysis from GEO database by Toro-Domínguez, Daniel, Martorell-Marugán, Jordi, López-Domínguez, Raúl, García-Moreno, Adrián, González-Rumayor, Víctor, Alarcón-Riquelme, Marta E, Carmona-Sáez, Pedro

“…Abstract Summary The Gene Expression Omnibus (GEO) database provides an invaluable resource of publicly available gene expression data that can be integrated…”
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Precision medicine in autoimmune diseases: fact or fiction by Toro-Domínguez, Daniel, Alarcón-Riquelme, Marta E

“…Much is said about precision medicine, but its real significance and potential are far from certain. Several studies in each of the autoimmune diseases have…”
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Moving towards a molecular taxonomy of autoimmune rheumatic diseases by Barturen, Guillermo, Beretta, Lorenzo, Cervera, Ricard, Van Vollenhoven, Ronald, Alarcón-Riquelme, Marta E.

“…Key Points Current systemic autoimmune disease classification criteria are commonly used for diagnosing diseases and tend to be ambiguous, generic or difficult…”
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BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation by Wu, Ying-Yu, Kumar, Ramesh, Iida, Ryuji, Bagavant, Harini, Alarcón-Riquelme, Marta E

“…The purpose of our study was to investigate the effects of the adaptor Bank1 in TLR7 signaling using the B6.Sle1.yaa mouse, a lupus model that develops disease…”
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Urinary and plasma metabolite differences detected by HPLC-ESI-QTOF-MS in systemic sclerosis patients by Fernández-Ochoa, Álvaro, Quirantes-Piné, Rosa, Borrás-Linares, Isabel, Gemperline, David, Alarcón Riquelme, Marta E., Beretta, Lorenzo, Segura-Carretero, Antonio

“…•Metabolic differences in Systemic Sclerosis were found in plasma and urine samples.•The main deregulated metabolites were acylcarnitines, acylglycines and…”
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Genetics of systemic lupus erythematosus and Sjögrenʼs syndrome: an update by Teruel, Maria, Alarcón-Riquelme, Marta E

“…PURPOSE OF REVIEWTo describe the recent studies on the genetics of systemic lupus erythematosus (SLE) and Sjögrenʼs syndrome. RECENT FINDINGSWe overview the…”
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A Summary on the Genetics of Systemic Lupus Erythematosus, Rheumatoid Arthritis, Systemic Sclerosis, and Sjögren’s Syndrome by Ortiz-Fernandez, L, Martin, J, Alarcon-Riquelme, ME

“…Systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and Sjögren’s syndrome are four major autoimmune rheumatic diseases characterized by…”
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Shared signatures between rheumatoid arthritis, systemic lupus erythematosus and Sjögren's syndrome uncovered through gene expression meta-analysis by Toro-Domínguez, Daniel, Carmona-Sáez, Pedro, Alarcón-Riquelme, Marta E

“…Systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and Sjögren's syndrome (SjS) are inflammatory systemic autoimmune diseases (SADs) that share…”
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B Cells and Microbiota in Autoimmunity by Botía-Sánchez, María, Alarcón-Riquelme, Marta E., Galicia, Georgina

“…Trillions of microorganisms inhabit the mucosal membranes maintaining a symbiotic relationship with the host’s immune system. B cells are key players in this…”
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Metabolic Disturbances in Urinary and Plasma Samples from Seven Different Systemic Autoimmune Diseases Detected by HPLC-ESI-QTOF-MS by Fernández-Ochoa, Álvaro, Brunius, Carl, Borrás-Linares, Isabel, Quirantes-Piné, Rosa, Cádiz-Gurrea, María de la Luz, PRECISESADS Clinical Consortium, Alarcón Riquelme, Marta E, Segura-Carretero, Antonio

“…Systemic autoimmune diseases (SADs) are characterized by dysfunctioning of the immune system, which causes damage in several tissues and organs. Among these…”
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Towards the taxonomy of human disease by Hofmann-Apitius, Martin, Alarcón-Riquelme, Marta E., Chamberlain, Chris, McHale, Duncan

“…Consortia have begun to establish 'mechanism-based taxonomies' for inflammatory and neurodegenerative diseases that could aid drug development and personalized…”
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Microbial and metabolic multi‐omic correlations in systemic sclerosis patients by Bellocchi, Chiara, Fernández‐Ochoa, Álvaro, Montanelli, Gaia, Vigone, Barbara, Santaniello, Alessandro, Milani, Christian, Quirantes‐Piné, Rosa, Borrás‐Linares, Isabel, Ventura, Marco, Segura‐Carrettero, Antonio, Alarcón‐Riquelme, Marta Eugenia, Beretta, Lorenzo

“…Intestinal microbiota has been associated with systemic autoimmune diseases, yet the functional consequences of these associations are elusive. We…”
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Omics studies: their use in diagnosis and reclassification of SLE and other systemic autoimmune diseases by Teruel, Maria, Chamberlain, Chris, Alarcón-Riquelme, Marta E

“…Omics studies of systemic autoimmune diseases (SADs) in general, and SLE in particular, have delivered isolated information from transcriptome, epigenome,…”
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A survey of gene expression meta-analysis: methods and applications by Toro-Domínguez, Daniel, Villatoro-García, Juan Antonio, Martorell-Marugán, Jordi, Román-Montoya, Yolanda, Alarcón-Riquelme, Marta E, Carmona-Sáez, Pedro

“…Abstract The increasing use of high-throughput gene expression quantification technologies over the last two decades and the fact that most of the published…”
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BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling by Bernal-Quirós, Manuel, Wu, Ying-Yu, Alarcón-Riquelme, Marta E, Castillejo-López, Casimiro

“…The B cell adaptor protein with ankyrin repeats (BANK1) and the B lymphoid tyrosine kinase (BLK) have been genetically associated with autoimmunity. The…”
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