Search Results - "Alan Perelson"

Mechanistic Modeling of SARS‐CoV‐2 and Other Infectious Diseases and the Effects of Therapeutics by Perelson, Alan S., Ke, Ruian

“…Modern viral kinetic modeling and its application to therapeutics is a field that attracted the attention of the medical, pharmaceutical, and modeling…”
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Post-treatment control of HIV infection by Conway, Jessica M., Perelson, Alan S.

“…Antiretroviral therapy (ART) for HIV is not a cure. However, recent studies suggest that ART, initiated early during primary infection, may induce…”
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Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy by Rong, Libin, Perelson, Alan S

“…Although potent combination therapy is usually able to suppress plasma viral loads in HIV-1 patients to below the detection limit of conventional clinical…”
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Mathematical modeling of within‐host Zika virus dynamics by Best, Katharine, Perelson, Alan S

“…Summary Recent Zika virus outbreaks have been associated with severe outcomes, especially during pregnancy. A great deal of effort has been put toward…”
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Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action by Czuppon, Peter, Débarre, Florence, Gonçalves, Antonio, Tenaillon, Olivier, Perelson, Alan S, Guedj, Jérémie, Blanquart, François

“…Repurposed drugs that are safe and immediately available constitute a first line of defense against new viral infections. Despite limited antiviral activity…”
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In vivo kinetics of SARS-CoV-2 infection and its relationship with a person’s infectiousness by Ke, Ruian, Zitzmann, Carolin, Ho, David D., Ribeiro, Ruy M., Perelson, Alan S.

“…The within-host viral kinetics of SARS-CoV-2 infection and how they relate to a person’s infectiousness are not well understood. This limits our ability to…”
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Modeling the within-host dynamics of HIV infection by Perelson, Alan S, Ribeiro, Ruy M

“…The new field of viral dynamics, based on within-host modeling of viral infections, began with models of human immunodeficiency virus (HIV), but now includes…”
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Regulation of T cell expansion by antigen presentation dynamics by Mayer, Andreas, Zhang, Yaojun, Perelson, Alan S., Wingreen, Ned S.

“…An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of…”
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Modeling within-host dynamics of influenza virus infection including immune responses by Pawelek, Kasia A, Huynh, Giao T, Quinlivan, Michelle, Cullinane, Ann, Rong, Libin, Perelson, Alan S

“…Influenza virus infection remains a public health problem worldwide. The mechanisms underlying viral control during an uncomplicated influenza virus infection…”
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Quantifying T lymphocyte turnover by De Boer, Rob J., Perelson, Alan S.

“…Peripheral T cell populations are maintained by production of naive T cells in the thymus, clonal expansion of activated cells, cellular self-renewal (or…”
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Modelling hepatitis C therapy—predicting effects of treatment by Perelson, Alan S., Guedj, Jeremie

“…Key Points After patients receive therapy for HCV infection, HCV RNA declines in a biphasic manner, the first phase reflects viral clearance, the second phase…”
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Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising by Luo, Shishi, Perelson, Alan S.

“…The past decade has seen the discovery of numerous broad and potent monoclonal antibodies against HIV type 1 (HIV-1). Eliciting these antibodies via…”
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How robust are estimates of key parameters in standard viral dynamic models? by Zitzmann, Carolin, Ke, Ruian, Ribeiro, Ruy M, Perelson, Alan S

“…Mathematical models of viral infection have been developed, fitted to data, and provide insight into disease pathogenesis for multiple agents that cause…”
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Modeling resistance to the broadly neutralizing antibody PGT121 in people living with HIV-1 by Cassidy, Tyler, Stephenson, Kathryn E, Barouch, Dan H, Perelson, Alan S

“…PGT121 is a broadly neutralizing antibody in clinical development for the treatment and prevention of HIV-1 infection via passive administration. PGT121…”
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Impact of different oseltamivir regimens on treating influenza A virus infection and resistance emergence: insights from a modelling study by Canini, Laetitia, Conway, Jessica M, Perelson, Alan S, Carrat, Fabrice

“…Several studies have proven oseltamivir to be efficient in reducing influenza viral titer and symptom intensity. However, the usefulness of oseltamivir can be…”
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Residual Viremia in Treated HIV+ Individuals by Conway, Jessica M, Perelson, Alan S

“…Antiretroviral therapy (ART) effectively controls HIV infection, suppressing HIV viral loads. However, some residual virus remains, below the level of…”
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On Identifiability of Nonlinear ODE Models and Applications in Viral Dynamics by Miao, Hongyu, Xia, Xiaohua, Perelson, Alan S., Wu, Hulin

“…Ordinary differential equations (ODEs) are a powerful tool for modeling dynamic processes with wide applications in a variety of scientific fields. Over the…”
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Rapid emergence of protease inhibitor resistance in hepatitis C virus by Rong, Libin, Dahari, Harel, Ribeiro, Ruy M, Perelson, Alan S

“…About 170 million people worldwide are infected with hepatitis C virus (HCV). The current standard therapy leads to sustained viral elimination in only…”
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Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues by Fletcher, Courtney V., Staskus, Kathryn, Wietgrefe, Stephen W., Rothenberger, Meghan, Reilly, Cavan, Chipman, Jeffrey G., Beilman, Greg J., Khoruts, Alexander, Thorkelson, Ann, Schmidt, Thomas E., Anderson, Jodi, Perkey, Katherine, Stevenson, Mario, Perelson, Alan S., Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.

“…Antiretroviral therapy can reduce HIV-1 to undetectable levels in peripheral blood, but the effectiveness of treatment in suppressing replication in lymphoid…”
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Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers by Conway, Jessica M, Perelson, Alan S, Li, Jonathan Z

“…Antiretroviral therapy (ART) effectively controls HIV infection, suppressing HIV viral loads. Suspension of therapy is followed by rebound of viral loads to…”
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