Search Results - "Alan, Jamie K"

Mutationally activated Rho GTPases in cancer by Alan, Jamie K, Lundquist, Erik A

“…The Rho family of GTPases (members of the Ras superfamily) are best known for their roles in regulating cytoskeletal dynamics. It is also well established that…”
Get full text

The Atypical Rho GTPase CHW-1 Works with SAX-3/Robo To Mediate Axon Guidance in Caenorhabditis elegans by Alan, Jamie K, Robinson, Sara K, Magsig, Katie L, Demarco, Rafael S, Lundquist, Erik A

“…During development, neuronal cells extend an axon toward their target destination in response to a cue to form a properly functioning nervous system. Rho…”
Get full text

Regulation of the Rho Family Small GTPase Wrch-1/RhoU by C-Terminal Tyrosine Phosphorylation Requires Src by Alan, Jamie K., Berzat, Anastacia C., Dewar, Brian J., Graves, Lee M., Cox, Adrienne D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Transforming Rho Family GTPase Wrch-1 Disrupts Epithelial Cell Tight Junctions and Epithelial Morphogenesis by Brady, Donita C., Alan, Jamie K., Madigan, James P., Fanning, Alan S., Cox, Adrienne D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Analysis of Rho GTPase function in axon pathfinding using Caenorhabditis elegans by Alan, Jamie K, Lundquist, Erik A

“…We provide information and protocols for the analysis of Rho GTPase function in axon pathfinding in Caenorhabditis elegans. The powerful molecular, genetic,…”
Get more information

PI3K Functions Downstream of Cdc42 to Drive Cancer phenotypes in a Melanoma Cell Line by Poku, Rosemary, Amissah, Felix, Alan, Jamie K.

“…Rho proteins are part of the Ras superfamily, which function to modulate cytoskeletal dynamics including cell adhesion and motility. Recently, an activating…”
Get full text

Protein kinase C and epidermal growth factor stimulation of Raf1 potentiates adenylyl cyclase type 6 activation in intact cells by Beazely, Michael A, Alan, Jamie K, Watts, Val J

“…Adenylyl cyclase type 6 (AC6) activity is inhibited by protein kinase C (PKC) in vitro; however, in intact cells, PKC activation does not inhibit the activity…”
Get more information

RhoGDI2 antagonizes ovarian carcinoma growth, invasion and metastasis by Stevens, Ellen V., Banet, Natalie, Onesto, Cercina, Plachco, Ana, Alan, Jamie K., Nikolaishvili-Feinberg, Nana, Midkiff, Bentley R., Kuan, Pei Fen, Liu, Jinsong, Miller, C. Ryan, Vigil, Dominico, Graves, Lee M., Der, Channing J.

“…Previous studies described functional roles for Rho GDP dissociation inhibitor 2 (RhoGDI2) in bladder, gastric and breast cancers. However, only limited…”
Get full text

A Novel Approach to Addiction Medicine Education for Undergraduate Medical Students by Malinowski, Robert, Poland, Cara, Alan, Jamie K., Walsh, Madison O.

“…A virtual addiction medicine elective was developed using interactive multimedia modules, active learning strategies, and patient-based cases. Student had…”
Get full text

Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells by González-Pérez, Vanessa, Reiner, David J, Alan, Jamie K, Mitchell, Cicely, Edwards, Lloyd J, Khazak, Vladimir, Der, Channing J, Cox, Adrienne D

“…Activation of the mammalian Ras-Raf-MEK-ERK MAPK signaling cascade promotes cellular proliferation, and activating Ras mutations are implicated in cancer onset…”
Get full text

Diclofenac Enhances Docosahexaenoic Acid-Induced Apoptosis in Vitro in Lung Cancer Cells by Poku, Rosemary A., Jones, Kylee J., Van Baren, Megan, Alan, Jamie K., Amissah, Felix

“…Polyunsaturated fatty acids (PUFAs) and non-steroidal anti-inflammatory drugs (NSAIDs) show anticancer activities through diverse molecular mechanisms…”
Get full text

Multiple cytoskeletal pathways and PI3K signaling mediate CDC-42-induced neuronal protrusion in C. elegans by Alan, Jamie K, Struckhoff, Eric C, Lundquist, Erik A

“…Rho GTPases are key regulators of cellular protrusion and are involved in many developmental events including axon guidance during nervous system development…”
Get full text

Antagonism of neurosteroid modulation of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol by Kelley, Stephen P., Alan, Jamie K., O'Buckley, Todd K., Mennerick, Steven, Krishnan, Kathiresan, Covey, Douglas F., Leslie Morrow, A.

“…Endogenous pregnane neurosteroids are allosteric modulators at γ-aminobutyric acid type-A (GABA A) receptors at nanomolar concentrations. There is direct…”
Get full text

An ELISA based method for quantifying arabinoxylan in wheat flour by Hoffstetter, Amber L., Griffin, Daniel P., Brown, Linda K., Alan, Jamie K., Olson, Eric L.

“…Arabinoxylans (AX) are a type of dietary fiber present in cereal grains. Recent studies have shown consuming water-extractable AX (WE-AX) can reduce blood…”
Get full text

Tyrosine kinase modulation of trafficking and biological functions of the atypical Rho GTPase, Wrch-1 by Alan, Jamie K

“…Wrch-1 is an atypical Rho family small GTPase with roles in oncogenic transformation, epithelial cell morphogenesis, osteoclastogenesis, and migration. We have…”
Get full text