Search Results - "Alamri, Ali H"
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Enhancing plant-derived smart nano inhibitor in targeting mammalian target of rapamycin (mTOR) in breast cancer using Curcuma longa-derived compound curcumin
Published in Environmental science and pollution research international (01-07-2024)“…Breast cancer is a diverse female malignancy; its classification is based on clinical evidence and pathological elucidation. Large public drug screening data…”
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A detailed insight of the tumor targeting using nanocarrier drug delivery system
Published in Drug delivery (01-12-2023)“…Human struggle against the deadly disease conditions is continued since ages. The contribution of science and technology in fighting against these diseases…”
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3
Nanotechnological synergy of mangiferin and curcumin in modulating PI3K/Akt/mTOR pathway: a novel front in ovarian cancer precision therapeutics
Published in Frontiers in pharmacology (04-01-2024)“…Ovarian cancer, colloquially termed the "silent killer" among gynecological malignancies, remains elusive due to its often-asymptomatic progression and…”
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Green Synthesis, Characterizations of Zinc Oxide Nanoparticles from Aqueous Leaf Extract of Tridax procumbens Linn. and Assessment of their Anti-Hyperglycemic Activity in Streptozoticin-Induced Diabetic Rats
Published in Materials (18-11-2022)“…Herein, zinc oxide nanoparticles (ZnO NPs) were greenly synthesized from Tridax procumbens aqueous leaf extract (TPE) and characterized physically (e.g.,…”
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Novel Drug Delivery Systems as an Emerging Platform for Stomach Cancer Therapy
Published in Pharmaceutics (29-07-2022)“…Cancer has long been regarded as one of the world's most fatal diseases, claiming the lives of countless individuals each year. Stomach cancer is a prevalent…”
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Cyclodextrins and Amino Acids Enhance Solubility and Tolerability of Retinoic Acid/Tretinoin: Molecular Docking, Physicochemical, Cytotoxicity, Scratch Assay, and Topical Gel Formulations Investigation
Published in Pharmaceutics (25-06-2024)“…With increasing longevity globally, the search for effective and patient-friendly anti-aging solutions has been growing. Retinoic acid (Ret) is an FDA-approved…”
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Enhancing Oral Bioavailability of Simvastatin Using Uncoated and Polymer-Coated Solid Lipid Nanoparticles
Published in Pharmaceutics (01-06-2024)“…Simvastatin (SVA) is a well-prescribed drug for treating cardiovascular and hypercholesterolemia. Due to the extensive hepatic first-pass metabolism and poor…”
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Fabrication, In Vitro, and In Vivo Assessment of Eucalyptol-Loaded Nanoemulgel as a Novel Paradigm for Wound Healing
Published in Pharmaceutics (01-09-2022)“…Wounds are the most common causes of mortality all over the world. Topical drug delivery systems are more efficient in treating wounds as compared to oral…”
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Anti-Proliferative Potential of Quercetin Loaded Polymeric Mixed Micelles on Rat C6 and Human U87MG Glioma Cells
Published in Pharmaceutics (06-08-2022)“…Quercetin (Qu) is a natural flavonoid present in many commonly consumed food items and is also identified as a potential anticancer agent. The present study…”
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Development and Evaluation of Solid Lipid Nanoparticles for the Clearance of Aβ in Alzheimer's Disease
Published in Pharmaceutics (09-01-2023)“…Aggregation of Amyloid-β (Aβ) leads to the formation and deposition of neurofibrillary tangles and plaques which is the main pathological hallmark of…”
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Carvedilol Precipitation Inhibition by the Incorporation of Polymeric Precipitation Inhibitors Using a Stable Amorphous Solid Dispersion Approach: Formulation, Characterization, and In Vitro In Vivo Evaluation
Published in Polymers (17-11-2022)“…An amorphous solid dispersion (ASD) of carvedilol (CVL) was prepared via the solvent evaporation method, using cellulose derivatives as polymeric precipitation…”
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Formulation development of lipid polymer hybrid nanoparticles of doxorubicin and its in-vitro, in-vivo and computational evaluation
Published in Frontiers in pharmacology (07-02-2023)“…The purpose of this study was to assess the parameters of doxorubicin (DOX) loaded lipid polymer hybrid nanoparticles (LPHNs) formulation development, and then…”
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Development and Characterization of Oral Raft Forming In Situ Gelling System of Neratinib Anticancer Drug Using 32 Factorial Design
Published in Polymers (21-06-2022)“…Neratinib (NTB) is an irreversible inhibitor of pan-human epidermal growth factor receptor (HER-2) tyrosine kinase and is used in the treatment of breast…”
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Rapid oral transmucosal delivery of zaleplon-lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation
Published in Drug delivery (31-12-2022)“…Based on the administration convenience, transmucosal buccal drug delivery allows special strength points over peroral routes for systemic delivery. It could…”
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Development of paroxetine loaded nanotransferosomal gel for intranasal delivery with enhanced antidepressant activity in rats
Published in Colloids and surfaces, B, Biointerfaces (01-02-2025)“…The aim of this study was to develop paroxetine (PXT) loaded nanotransferosomal gel (PXT-NTFG) for intranasal brain delivery. The process involved fabricating…”
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Sodium alginate-based smart gastro-retentive drug delivery system of revaprazan loaded SLNs; Formulation and characterization
Published in International journal of biological macromolecules (31-12-2023)“…Revaprazan (REV), a novel reversible Proton Pump Inhibitor (PPI) used to treat peptic ulcers, faces challenges in therapeutic efficacy due to its poor…”
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Formulation and statistical optimization of letrozole loaded nanotransferosomal gel for tumor targeting
Published in Pharmaceutical development and technology (08-08-2024)“…Letrozole (LTZ) is used as first-line treatment for hormone-positive breast cancer (BC) in postmenopausal women. However, its poor aqueous solubility and…”
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The Use of Nanoneedles in Drug Delivery: an Overview of Recent Trends and Applications
Published in AAPS PharmSciTech (19-10-2023)“…Nanoneedles (NN) are growing rapidly as a means of navigating biological membranes and delivering therapeutics intracellularly. Nanoneedle arrays (NNA) are…”
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Efficacy of Various Types of Berries Extract for the Synthesis of ZnO Nanocomposites and Exploring Their Antimicrobial Potential for Use in Herbal Medicines
Published in BioMed research international (16-08-2022)“…Nanoscience has developed various greener approaches as an alternate method for the synthesis of nanoparticles and nanocomposites. The present study discusses…”
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Solubility enhancement of decitabine as anticancer drug via green chemistry solvent: Novel computational prediction and optimization
Published in Arabian journal of chemistry (01-12-2022)“…Nowadays, supercritical fluid technology (SFT) has been an interesting scientific subject in disparate industrial-based activities such as drug delivery,…”
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