Association of three polymorphisms selected from a genome-wide association study with coronary heart disease in the Tunisian population

Despite extensive exploration of many genes, strong evidence of a molecular genetic association with coronary heart disease (CHD) or myocardial infarction (MI) remains to be obtained. Recently, significant interest has emerged in mapping genetic susceptibility for complex traits through whole-genome...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of thrombosis and thrombolysis Vol. 29; no. 1; pp. 114 - 118
Main Authors:	Ghazouani, Lakhdar, Khalifa, Sonia Ben Hadj, Abboud, Nesrine, Perret, Claire, Nicaud, Viviane, Khalfallah, Ali Ben, Alamawi, Wassim Youssef, Cambien, François, Mahjoub, Touhami
Format:	Journal Article
Language:	English
Published:	Boston Springer US 2010 Springer Nature B.V
Subjects:	Aged Aminohydrolases - genetics Cardiology Case-Control Studies Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 9 Coronary Disease - genetics Female Formate-Tetrahydrofolate Ligase - genetics Genome Genome-Wide Association Study Genotype Hematology Humans Male Medicine Medicine & Public Health Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics Middle Aged Multienzyme Complexes - genetics Polymorphism, Single Nucleotide Tunisia Tunisia Genetics Rs polymorphisms Coronary heart disease Atherosclerosis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Despite extensive exploration of many genes, strong evidence of a molecular genetic association with coronary heart disease (CHD) or myocardial infarction (MI) remains to be obtained. Recently, significant interest has emerged in mapping genetic susceptibility for complex traits through whole-genome studies association generating promoting data that will determine the genetic contribution to common human diseases such as coronary heart disease. The aim of the present case-control study including 324 healthy controls and 296 patients with coronary heart disease from Tunisia, was to assess relation between three polymorphisms previously reported to be strongly associated with coronary heart disease in the Welcome Trust Case Control Consortium (WTCCC) and the German myocardial infarction family studies: locus 9p21.3 (rs 1333049), locus 6q25.1 (rs6922269) and 2q36.3 (rs2943634). By single locus analysis, no differences in genotype distribution and allelic frequency were found between the two groups of study. The risk allele (C) for rs2943634 was less frequent among Tunisian population than in controls from the WTCCC and German studies (57% vs 65%). The three SNPs previously reported to be associated with CHD were not replicated in our small sample.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0929-5305 1573-742X
DOI:	10.1007/s11239-009-0336-0