Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways

(SF), a valuable Bangladeshi fruit, is considered an alternative therapeutic agent. Mainly, seeds are used as nutritional phytotherapy to ease physical and mental status by preventing chronic diseases. Here, we scrutinized the seed's fundamental importance in traditional medicine by following a...

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Bibliographic Details
Published in:	Life (Basel, Switzerland) Vol. 11; no. 2; p. 155
Main Authors:	Moni, Jannatul Nasma Rupa, Adnan, Md, Tareq, Abu Montakim, Kabir, Md Imtiazul, Reza, A S M Ali, Nasrin, Mst Samima, Chowdhury, Kamrul Hasan, Sayem, Syed Al Jawad, Rahman, Md Atiar, Alam, Ahm Khurshid, Alam, Seema Binte, Sakib, Mahfuz Ahmed, Oh, Ki Kwang, Cho, Dong Ha, Capasso, Raffaele
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 17-02-2021 MDPI AG
Subjects:	analgesic and anti-inflammatory computational studies GC-MS neuropharmacology Syzygium fruticosum thrombolytic GC-MS Syzygium fruticosum analgesic and anti-inflammatory computational studies neuropharmacology thrombolytic
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Summary:	(SF), a valuable Bangladeshi fruit, is considered an alternative therapeutic agent. Mainly, seeds are used as nutritional phytotherapy to ease physical and mental status by preventing chronic diseases. Here, we scrutinized the seed's fundamental importance in traditional medicine by following an integrated approach combining in vivo, in vitro, and in silico studies. The SF was fractionated with different solvents, and the ethyl acetate fraction of SF (EaF-SF) was further studied. Mice treated with EaF-SF (200 and 400 mg/kg) manifested anxiolysis evidenced by higher exploration in elevated plus maze and hole board tests. Similarly, a dose-dependent drop of immobility time in a forced swimming test ensured significant anti-depressant activity. Moreover, higher dose treatment exposed reduced exploratory behaviour resembling decreased movement and prolonged sleeping latency with a quick onset of sleep during the open field and thiopental-induced sleeping tests, respectively. In parallel, EaF-SF significantly ( < 0.001) and dose-dependently suppressed acetic acid and formalin-induced pain in mice. Also, a noteworthy anti-inflammatory activity and a substantial ( < 0.01) clot lysis activity (thrombolytic) was observed. Gas chromatography-mass spectrometry (GC-MS) analysis resulted in 49 bioactive compounds. Among them, 12 bioactive compounds with Lipinski's rule and safety confirmation showed strong binding affinity (molecular docking) against the receptors of each model used. To conclude, the seed is a prospective source of health-promoting effects that can be an excellent candidate for preventing degenerative diseases.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	2075-1729 2075-1729
DOI:	10.3390/life11020155