Search Results - "Alam, Neyaz"
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Supra-physiological concentration of glyoxylate inhibits proliferation of human colon cancer cells through oxidative stress
Published in Life sciences (1973) (15-08-2018)“…The cytotoxic response of an intermediate metabolite glyoxylate (Glx) on colon carcinoma has been evaluated in vitro. The anti-proliferative effect of Glx was…”
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2
Phosphorylation of EphA2 receptor and vasculogenic mimicry is an indicator of poor prognosis in invasive carcinoma of the breast
Published in Breast cancer research and treatment (2020)“…Purpose The occurrence of vasculogenic mimicry (VM) and EphA2-mediated tumour progression are associated with poor prognosis in various solid tumours. Here, we…”
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3
RGS5–TGFβ–Smad2/3 axis switches pro- to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth
Published in Cell death and differentiation (01-11-2021)“…Regulator-of-G-protein-signaling-5 (RGS5), a pro-apoptotic/anti-proliferative protein, is a signature molecule of tumor-associated pericytes, highly expressed…”
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4
Study of association and molecular analysis of human papillomavirus in breast cancer of Indian patients: Clinical and prognostic implication
Published in PloS one (28-02-2017)“…Human papillomavirus (HPV) causes tumors primarily Cervical cancer. Recently, inconsistent reports came up in Breast cancer (BC) too. In India, despite…”
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Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer
Published in Journal of cell communication and signaling (01-09-2023)“…Vasculogenic mimicry (VM), defined as an endothelial cell independent alternative mechanism of blood and nutrient supply by dysregulated tumor cells, is…”
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6
Association of mTOR pathway with risk of gastric cancer in male smoker with potential prognostic significance
Published in Molecular biology reports (01-10-2020)“…Aberrant expression of mTOR signaling pathway is significantly associated with gastric cancer. However, the effect of smoking on mTOR expression and its…”
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Subtype‐specific alterations of the Wnt signaling pathway in breast cancer: Clinical and prognostic significance
Published in Cancer science (01-02-2012)“…The aim of the study is to understand the importance of the Wnt/β‐catenin pathway in the development of breast cancer (BC) and its association with different…”
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Differential Wnt-β- catenin pathway activation in HPV positive and negative oral epithelium is transmitted during head and neck tumorigenesis: clinical implications
Published in Medical microbiology and immunology (01-02-2021)“…The aim of this study is to understand the association of HPV infection and wnt-β-catenin self-renewal pathway in development of head and neck squamous cell…”
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Downregulation of beta-catenin in chemo-tolerant TNBC through changes in receptor and antagonist profiles of the WNT pathway: Clinical and prognostic implications
Published in Cellular oncology (Dordrecht) (01-08-2020)“…Purpose In approximately 30% of triple-negative breast cancer (TNBC) patients a complete pathological response is achieved. However, after neo-adjuvant…”
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Differential transmission of the molecular signature of RBSP3, LIMD1 and CDC25A in basal/ parabasal versus spinous of normal epithelium during head and neck tumorigenesis: A mechanistic study
Published in PloS one (19-04-2018)“…Head and neck squamous cell carcinoma (HNSCC) is a global disease and mortality burden, necessitating the elucidation of its molecular progression for…”
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Association of Augmented Immune-Staining of G-Quadruplex Tertiary DNA Structure in Chemo-Tolerant TNBC with Downregulation of WNT/Epidermal Growth Factor Receptor Pathway receptor Genes: A Pilot Clinicopathological Study
Published in Journal of radiation and cancer research (01-01-2023)“…Purpose: The aim of the study is to understand the involvement of G-Quadruplex (G-Q) structures in altering the expression profile of WNT/epidermal growth…”
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12
Lupeol synergizes with 5-fluorouracil to combat c-MET/EphA2 mediated chemoresistance in triple negative breast cancer
Published in iScience (15-12-2023)“…Triple-negative breast cancer (TNBC) is the most elusive subtype of breast cancer that encounters treatment dilemmas owing to the paucity of druggable targets…”
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Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma
Published in Molecular cancer (06-11-2008)“…Younger women with breast carcinoma (BC) exhibits more aggressive pathologic features compared to older women; young age could be an independent predictor of…”
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Frequent alterations of hMLH1 and RBSP3/HYA22 at chromosomal 3p22.3 region in early and late‐onset breast carcinoma: clinical and prognostic significance
Published in Cancer science (01-10-2008)“…Young age can be an independent prognostic factor for adverse prognosis in women with breast carcinoma (BC). In younger women, BC exhibited more aggressive…”
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Activation of epidermal growth factor receptor/insulin-like growth factor 1 receptor-β-Catenin-CD44 pathway in periampullary cancer
Published in Journal of radiation and cancer research (01-01-2020)“…Background: Periampullary cancer (PC) is a global medical burden. Less than 5% of patients experience an overall survival of 5 years or more. The study aims to…”
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Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: clinical and prognostic implications
Published in Human genetics (01-03-2009)“…Deletion of chromosomal 3p12.3 was suggested to be associated with dysplastic lesions of head and neck. This region harbors two candidate tumor suppressors…”
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CD44highCD24low molecular signature determines the Cancer Stem Cell and EMT phenotype in Oral Squamous Cell Carcinoma
Published in Stem cell research (01-03-2016)“…Almost all epithelial tumours contain cancer stem-like cells, which possess a unique property of self-renewal and differentiation. In oral cancer, several…”
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CD44 high CD24 low molecular signature determines the Cancer Stem Cell and EMT phenotype in Oral Squamous Cell Carcinoma
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Frequent alterations of LOH11CR2A, PIG8 and CHEK1 genes at chromosomal 11q24.1-24.2 region in breast carcinoma: Clinical and prognostic implications
Published in Molecular oncology (01-10-2011)“…To understand the importance of frequent deletions at chromosome 11q24.1-24.2 region in breast carcinoma, alterations (deletion/methylation) of the candidate…”
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Abstract 1985: Activation of EGFR/IGF1R - beta catenin - CD44 pathway in periampullary cancer
Published in Cancer research (Chicago, Ill.) (01-07-2021)“…Abstract Background: Periampullary cancer (PC) is a global medical burden, although infrequent but less than 5% of patients experience an overall survival of…”
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