Search Results - "Alam, M Mumtaz"

Nerolidol attenuates cyclophosphamide-induced cardiac inflammation, apoptosis and fibrosis in Swiss Albino mice by Iqubal, Ashif, Sharma, Sumit, Ansari, Mohd Asif, Najmi, Abul Kalam, Syed, Mansoor Ali, Ali, Javed, Alam, M. Mumtaz, Ahmad, Shaniya, Haque, Syed Ehtaishamul

“…Incidence and prevalence of cancer is an alarming situation globally. For the treatment of cancer many anticancer drugs have been developed but, unfortunately,…”
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Pyrazolines: a biological review by Marella, Akranth, Ali, Md Rahmat, Alam, Md Tauquir, Saha, Rikta, Tanwar, Omprakash, Akhter, Mymoona, Shaquiquzzaman, Md, Alam, M Mumtaz

“…Pyrazoline is an important five membered nitrogen heterocycle, which has been extensively researched upon. The ring is quite stable and has inspired chemists…”
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Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents by Tasneem, Sharba, Sheikh, Khursheed A., Naematullah, Md, Mumtaz Alam, M., Khan, Farah, Garg, Manika, Amir, Mohd, Akhter, Mymoona, Amin, Shaista, Haque, Anzarul, Shaquiquzzaman, Mohammad

“…[Display omitted] •A series of potent Cyanopyrimidine-hydrazone derivatives were synthesized and evaluated for their in-vitro anticancer screening on NCI 60…”
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Synthesis, in-Silico studies and biological evaluation of pyrimidine based thiazolidinedione derivatives as potential anti-diabetic agent by Amin, Shaista, Sheikh, Khursheed A, Iqubal, Ashif, Ahmed Khan, Mohammad, Shaquiquzzaman, M., Tasneem, Sharba, Khanna, Suruchi, Najmi, A.K., Akhter, Mymoona, Haque, Anzarul, Anwer, Tarique, Mumtaz Alam, M.

“…[Display omitted] •A novel series of pyrimidine-thiazolidinedione derivatives was synthesized.•In-silico molecular docking and ADME evaluation using…”
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Exploring cyclopropylamine containing cyanopyrimidines as LSD1 inhibitors: Design, synthesis, ADMET, MD analysis and anticancer activity profiling by Ahmad Sheikh, Khursheed, Parveen, Darakhshan, Mumtaz Alam, M., Azam, Faizul, Ahmed Khan, Mohammad, Akhter, Mymoona, Tasneem, Sharba, Meenu, Parvez, Suhel, Imtiyaz, Khalid, Rizvi, Moshahid A., Shaquiquzzaman, M.

“…[Display omitted] •A series of cyclopropylamine containing cyanopyrimidine derivatives were synthesized and evaluated for anticancer activity.•VIIb, VIIi and…”
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Recent updates on biological activities of oxadiazoles by Saha, Rikta, Tanwar, Omprakash, Marella, Akranth, Alam, M Mumtaz, Akhter, Mymoona

“…Among the plethora of heterocyclic nucleus discovered, the oxadiazoles have also been explored extensively. The oxadiazole structure has been demonstrated to…”
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Pyrrole: An insight into recent pharmacological advances with structure activity relationship by Ahmad, Shujauddin, Alam, Ozair, Naim, Mohd. Javed, Shaquiquzzaman, Mohammad, Alam, M. Mumtaz, Iqbal, Muzaffar

“…Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for the generation of library of enormous lead molecules. Owing to its…”
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N-acetyl-L-cysteine ameliorates mitochondrial dysfunction in ischemia/reperfusion injury via attenuating Drp-1 mediated mitochondrial autophagy by Ali, Mubashshir, Tabassum, Heena, Alam, M Mumtaz, Parvez, Suhel

“…Ischemic reperfusion (I/R) injury causes a wide array of functional and structure alternations of mitochondria, associated with oxidative stress and increased…”
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Levocabastine ameliorates cyclophosphamide-induced cardiotoxicity in Swiss albino mice: Targeting TLR4/NF-κB/NLRP3 signaling pathway by Akram, Wasim, Najmi, Abul Kalam, Alam, M. Mumtaz, Haque, Syed Ehtaishamul

“…Cyclophosphamide (CP), although a potent anti-cancer drug, causes cardiotoxicity as a side effect that limits its use. Hence, a specific medicine that can…”
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Therapeutic evolution of benzimidazole derivatives in the last quinquennial period by Akhtar, Wasim, Khan, Mohemmed Faraz, Verma, Garima, Shaquiquzzaman, M., Rizvi, M.A., Mehdi, Syed Hassan, Akhter, Mymoona, Alam, M. Mumtaz

“…Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained considerable attention in the field of contemporary medicinal chemistry. The moiety…”
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Nerolidol ameliorates cyclophosphamide-induced oxidative stress, neuroinflammation and cognitive dysfunction: Plausible role of Nrf2 and NF- κB by Iqubal, Ashif, Sharma, Sumit, Najmi, Abul Kalam, Syed, Mansoor Ali, Ali, Javed, Alam, M. Mumtaz, Haque, Syed Ehtaishamul

“…Cyclophosphamide (CP) is a potent anticancer and immunosuppressant drug. Studies have shown significant oxidative stress and cognitive impairment but…”
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The therapeutic journey of pyridazinone by Akhtar, Wasim, Shaquiquzzaman, M., Akhter, Mymoona, Verma, Garima, Khan, Mohemmed Faraz, Alam, M. Mumtaz

“…Pyridazinones have drawn a substantial attention within the field of research analysis and development. The moiety is a subject matter of intensive research…”
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4, 5-Dihydrooxazole-pyrazoline hybrids: Synthesis and their evaluation as potential antimalarial agents by Pandey, Ashutosh Kumar, Sharma, Supriya, Pandey, Minakshi, Alam, M. Mumtaz, Shaquiquzzaman, M., Akhter, Mymoona

“…A new series of oxazoline-pyrazoline hybrids (4a-p) were synthesized by condensation reaction of substituted oxazoline based chalcones (3a-m) and substituted…”
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Role of NLRP3 Inflammasome and Its Inhibitors as Emerging Therapeutic Drug Candidate for Alzheimer’s Disease: a Review of Mechanism of Activation, Regulation, and Inhibition by Sharma, Barkha, Satija, Garvit, Madan, Anish, Garg, Mansi, Alam, M. Mumtaz, Shaquiquzzaman, M., Khanna, Suruchi, Tiwari, Prachi, Parvez, Suhel, Iqubal, Ashif, Haque, Syed Ehtaishamul, Khan, Mohammad Ahmed

“…Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative disorders. The etiology and pathology of AD are complicated, variable, and yet to be…”
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Effect of melatonin on Aβ42 induced changes in the mitochondrial function related to Alzheimer’s disease in Drosophila melanogaster by Khatoon, Rehana, Rasheed, Md. Zeeshan, Rawat, Mahika, Alam, M. Mumtaz, Tabassum, Heena, Parvez, Suhel

“…[Display omitted] •Our study provides critical link between mitochondria dysfunction and Alzheimers Disease.•Melatonin has potential to restore the normal…”
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Unveiling novel diphenyl-1H-pyrazole based acrylates tethered to 1,2,3-triazole as promising apoptosis inducing cytotoxic and anti-inflammatory agents by Khan, Mohemmed Faraz, Anwer, Tarique, Bakht, Afroz, Verma, Garima, Akhtar, Wasim, Alam, M. Mumtaz, Rizvi, Moshahid Alam, Akhter, Mymoona, Shaquiquzzaman, Mohammad

“…[Display omitted] •1,2,3-triazole linked 3-(1,3-diphenyl-1H-pyrazol-4-yl)acrylates were synthesized.•6e, 6f and 6n inhibited proliferation of cell lines MCF-7,…”
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Effectiveness of estrogen and its derivatives over dexamethasone in the treatment of COVID-19 by Parveen, Darakhshan, Das, Anwesha, Amin, Shaista, Alam, M. Mumtaz, Akhter, Mymoona, Ahmed Khan, Mohammad, Ali, Ruhi, Anwer, Tarique, Sheikh, Khursheed A., Azam, Faizul, Shaquiquzzaman, M.

“…Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus and dexamethasone is a glucocorticoid widely used for its treatment…”
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Synthesis and HDAC1 inhibitory activity of a novel series of coumarin-based amide derivatives for treatment of cancer by Tasneem, Sharba, Alam, M Mumtaz, Parvez, Suhel, Pinky, Khan, Farah, Garg, Manika, Amir, Mohd, Akhter, Mymoona, Amin, Shaista, Khan, Mohammad Ahmed, Shaquiquzzaman, Mohammad

“…Histone deacetylases (HDACs) play a vital role in the epigenetic regulation of transcription and expression. HDAC1 overexpression is seen in many cancers. The…”
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Identification of novel small molecule non-peptidomimetic inhibitor for prolyl oligopeptidase through in silico and in vitro approaches by Shrivastava, Apeksha, Srivastava, Shubham, Malik, Ruchi, Alam, M. Mumtaz, Shaqiquzamman, M., Akhter, Mymoona

“…Prolyl oligopeptidase (POP) enzyme has been studied for various disorders, viz. Schizophrenia, Alzheimer's, Parkinson's, Depression, Inflammation, etc., for…”
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A review on synthetic procedures and applications of phosphorus oxychloride (POCl3) in the last biennial period (2018-19) by Amin, Shaista, Alam, M. Mumtaz, Akhter, Mymoona, Najmi, A. K., Siddiqui, Nadeem, Husain, Asif, Shaquiquzzaman, M.

“…Phosphorus oxychloride, POCl 3 , an important phosphorus compound, has diverse applications in synthetic chemistry. It plays an important role in chlorination,…”
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