Search Results - "Alam, Kazi A"

Molecular landscape of the overlap between Alzheimer's disease and somatic insulin-related diseases by Ruisch, I Hyun, Widomska, Joanna, De Witte, Ward, Mota, Nina R, Fanelli, Giuseppe, Van Gils, Veerle, Jansen, Willemijn J, Vos, Stephanie J B, Fóthi, Abel, Barta, Csaba, Berkel, Simone, Alam, Kazi A, Martinez, Aurora, Haavik, Jan, O'Leary, Aet, Slattery, David, Sullivan, Mairéad, Glennon, Jeffrey, Buitelaar, Jan K, Bralten, Janita, Franke, Barbara, Poelmans, Geert

“…Alzheimer's disease (AD) is a multifactorial disease with both genetic and environmental factors contributing to its etiology. Previous evidence has implicated…”
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Corrigendum: Addressing the Glycine‐Rich Loop of Protein Kinases by a Multi‐Facetted Interaction Network: Inhibition of PKA and a PKB Mimic by Lauber, Birgit S., Hardegger, Leo A., Alam, Kazi A., Lund, Bjarte A., Dumele, Oliver, Harder, Michael, Kuhn, Bernd, Engh, Richard A., Diederich, François

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Inhibitor binding to mutants of protein kinase A with GGGxxG and GxGxxA glycine‐rich loop motifs by Alam, Kazi A., Gani, Osman A. S. B. M., Engh, Richard A.

“…The conserved GxGxxG motif of protein kinases forms a beta turn at the tip of the flexible glycine‐rich loop and creates much of the ATP pocket binding…”
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Assessing protein kinase target similarity: Comparing sequence, structure, and cheminformatics approaches by Gani, Osman A., Thakkar, Balmukund, Narayanan, Dilip, Alam, Kazi A., Kyomuhendo, Peter, Rothweiler, Ulli, Tello-Franco, Veronica, Engh, Richard A.

“…In just over two decades, structure based protein kinase inhibitor discovery has grown from trial and error approaches, using individual target structures, to…”
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Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic by Lauber, Birgit S., Hardegger, Leo A., Asraful, Alam K., Lund, Bjarte A., Dumele, Oliver, Harder, Michael, Kuhn, Bernd, Engh, Richard A., Diederich, François

“…Protein kinases continue to be hot targets in drug discovery research, as they are involved in many essential cellular processes and their deregulation can…”
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