Search Results - "Alam, Jenefer"

Functionalization of Peptides and Proteins by Mukaiyama Aldol Reaction by Alam, Jenefer, Keller, Thomas H, Loh, Teck-Peng

“…The scope of the catalyst-free water-based Mukaiyama aldol reaction was explored through its application to the site-selective functionalization of N-terminal…”
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The Biosynthesis of GDP-l-Colitose:  C-3 Deoxygenation Is Catalyzed by a Unique Coenzyme B6-Dependent Enzyme by Beyer, Noelle, Alam, Jenefer, Hallis, Tina M, Guo, Zhihong, Liu, Hung-wen

“…l-Colitose (1) is a 3,6-dideoxyhexose found in the O-antigen of gram-negative lipopoly-saccharides. While the biosynthesis of many deoxysugars have previously…”
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Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors by Ho, Soo Yei, Alam, Jenefer, Jeyaraj, Duraiswamy Athisayamani, Wang, Weiling, Lin, Grace Ruiting, Ang, Shi Hua, Tan, Eldwin Sum Wai, Lee, May Ann, Ke, Zhiyuan, Madan, Babita, Virshup, David M, Ding, Li Jun, Manoharan, Vithya, Chew, Yun Shan, Low, Choon Bing, Pendharkar, Vishal, Sangthongpitag, Kanda, Hill, Jeffrey, Keller, Thomas H, Poulsen, Anders

“…Porcupine is an O-acyltransferase that regulates Wnt secretion. Inhibiting porcupine may block the Wnt pathway which is often dysregulated in various cancers…”
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Discovery and Optimization of a Porcupine Inhibitor by Duraiswamy, Athisayamani Jeyaraj, Lee, May Ann, Madan, Babita, Ang, Shi Hua, Tan, Eldwin Sum Wai, Cheong, Wei Wen Vivien, Ke, Zhiyuan, Pendharkar, Vishal, Ding, Li Jun, Chew, Yun Shan, Manoharan, Vithya, Sangthongpitag, Kanda, Alam, Jenefer, Poulsen, Anders, Ho, Soo Yei, Virshup, David M, Keller, Thomas H

“…Wnt proteins regulate various cellular functions and serve distinct roles in normal development throughout life. Wnt signaling is dysregulated in various…”
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Indium mediated allylation in peptide and protein functionalization by Alam, Jenefer, Keller, Thomas H, Loh, Teck-Peng

“…Indium-mediated allylation has been used in the site-selective functionalization of N-terminal aldehydes of peptides and proteins. This is the first…”
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Fragment-Based Ligand Design of Novel Potent Inhibitors of Tankyrases by Larsson, E. Andreas, Jansson, Anna, Ng, Fui Mee, Then, Siew Wen, Panicker, Resmi, Liu, Boping, Sangthongpitag, Kanda, Pendharkar, Vishal, Tai, Shi Jing, Hill, Jeffrey, Dan, Chen, Ho, Soo Yei, Cheong, Wei Wen, Poulsen, Anders, Blanchard, Stephanie, Lin, Grace Ruiting, Alam, Jenefer, Keller, Thomas H, Nordlund, Pär

“…Tankyrases constitute potential drug targets for cancer and myelin-degrading diseases. We have applied a structure- and biophysics-driven fragment-based ligand…”
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Pharmacophore Model for Wnt/Porcupine Inhibitors and Its Use in Drug Design by Poulsen, Anders, Ho, Soo Yei, Wang, Weiling, Alam, Jenefer, Jeyaraj, Duraiswamy A, Ang, Shi Hua, Tan, Eldwin Sum Wai, Lin, Grace Ruiting, Cheong, Vivien Wei Wen, Ke, Zhiyuan, Lee, May Ann, Keller, Thomas H

“…Porcupine is a component of the Wnt pathway which regulates cell proliferation, migration, stem cell self-renewal, and differentiation. The Wnt pathway has…”
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Peptide inhibitors of dengue virus NS3 protease. Part 1: Warhead by Yin, Zheng, Patel, Sejal J., Wang, Wei-Ling, Wang, Gang, Chan, Wai-Ling, Rao, K.R. Ranga, Alam, Jenefer, Jeyaraj, Duraiswamy A., Ngew, Xinyi, Patel, Viral, Beer, David, Lim, Siew Pheng, Vasudevan, Subhash G., Keller, Thomas H.

“…Substrate-based tetrapeptide inhibitors with various warheads were designed, synthesized, and evaluated against the Dengue virus NS3 protease. Effective…”
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Abstract 4449: A novel Porcupine inhibitor is effective in the treatment of cancers with RNF43 mutations by Ke, Zhiyuan, Madan, Babita, Lim, Shermaine Q.y., Wang, Sifang, Alam, Jenefer, Ho, Soo Yei, Jeyaraj, Duraiswamy Athisayamani, Ghosh, Kakaly, Chew, Yun Shan, Ding, Li Jun, Monoharan, Vithya, Pendharkar, Vishal, Ong, Esther, Hill, Jeffrey, Sangthongpitag, Kanda, Keller, Thomas, Lee, May Ann, Virshup, David M.

“…Abstract Various mutations in the Wnt pathway contribute to aberrant activation of Wnt signaling, which is implicated in multiple cancers. Besides the mutation…”
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Abstract C248: Novel PORCN inhibitors are safe and effective in the treatment of WNT-dependent cancers by Madan, Babita, Ke, Zhiyuan, Lim, Shermaine Q.y., Alam, Jenefer, Ho, Soo Yei, Jeyaraj, Duraiswamy A., Ghosh, Kakaly, Chew, Yun Shan, Aliyev, Jamal, Ding, Li Jun, Pendharkar, Vishal, Wang, Sifang, Sangthongpitag, Kanda, Keller, Thomas, Lee, May Ann, Virshup, David M.

“…Abstract Dysregulation of the Wnt signaling cascades is implicated in multiple disorders. There are 19 human Wnts that mediate signaling through diverse…”
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Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results by Pichota, Arkadius, Duraiswamy, Jeyaraj, Yin, Zheng, Keller, Thomas H., Alam, Jenefer, Liung, Sarah, Lee, Gladys, Ding, Mei, Wang, Gang, Chan, Wai Ling, Schreiber, Mark, Ma, Ida, Beer, David, Ngew, Xinyi, Mukherjee, Kakoli, Nanjundappa, Mahesh, Teo, Jeanette W.P., Thayalan, Pamela, Yap, Amelia, Dick, Thomas, Meng, Wuyi, Xu, Mei, Koehn, James, Pan, Shi-Hao, Clark, Kirk, Xie, Xiaoling, Shoen, Carolyn, Cynamon, Michael

“…Bacterial peptide deformylase (PDF) belongs to a subfamily of metalloproteases catalyzing the removal of the N-terminal formyl group from newly synthesized…”
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Biosynthesis of Colitose:  Expression, Purification, and Mechanistic Characterization of GDP-4-keto-6-deoxy-d-mannose-3-Dehydrase (ColD) and GDP-l-colitose Synthase (ColC) by Alam, Jenefer, Beyer, Noelle, Liu, Hung-wen

“…l-Colitose is a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides. To study the biosynthesis of this unusual sugar, we have cloned…”
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The Biosynthesis of GDP- l -Colitose:  C-3 Deoxygenation Is Catalyzed by a Unique Coenzyme B 6 -Dependent Enzyme by Beyer, Noelle, Alam, Jenefer, Hallis, Tina M., Guo, Zhihong, Liu, Hung-wen

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