Search Results - "Alam, Hasan B."

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation by Magupalli, Venkat Giri, Negro, Roberto, Tian, Yuzi, Hauenstein, Arthur V, Di Caprio, Giuseppe, Skillern, Wesley, Deng, Qiufang, Orning, Pontus, Alam, Hasan B, Maliga, Zoltan, Sharif, Humayun, Hu, Jun Jacob, Evavold, Charles L, Kagan, Jonathan C, Schmidt, Florian I, Fitzgerald, Katherine A, Kirchhausen, Tom, Li, Yongqing, Wu, Hao

“…Inflammasomes are supramolecular complexes that play key roles in immune surveillance. This is accomplished by the activation of inflammatory caspases, which…”
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Citrullinated Histone H3 as a Therapeutic Target for Endotoxic Shock in Mice by Deng, Qiufang, Pan, Baihong, Alam, Hasan B, Liang, Yingjian, Wu, Zhenyu, Liu, Baoling, Mor-Vaknin, Nirit, Duan, Xiuzhen, Williams, Aaron M, Tian, Yuzi, Zhang, Justin, Li, Yongqing

“…Sepsis results in millions of deaths every year, with acute lung injury (ALI) being one of the leading causes of mortality in septic patients. As neutrophil…”
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Trauma care: Finding a better way by Alam, Hasan B

“…In a Perspective, Hasan Alam discusses emerging treatment approaches in trauma care…”
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Citrullinated histone H3: A novel target for the treatment of sepsis by Li, Yongqing, MD, PhD, Liu, Zhengcai, MD, PhD, Liu, Baoling, MD, Zhao, Ting, MD, Chong, Wei, MD, PhD, Wang, Yanming, PhD, Alam, Hasan B., MD

“…Introduction We have recently demonstrated that in a rodent model of lipopolysaccharide (LPS)-induced shock, an increase in circulating citrullinated histone…”
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CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock by Pan, Baihong, Alam, Hasan B., Chong, Wei, Mobley, James, Liu, Baoling, Deng, Qiufang, Liang, Yinjian, Wang, Yanming, Chen, Eric, Wang, Tianbing, Tewari, Muneesh, Li, Yongqing

“…Current biomarkers for sepsis are limited by their non-specificity, short half-life, and insensitive response to therapy. Recently, we have demonstrated that…”
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Peptidylarginine Deiminase 2 in Host Immunity: Current Insights and Perspectives by Wu, Zhenyu, Li, Patrick, Tian, Yuzi, Ouyang, Wenlu, Ho, Jessie Wai-Yan, Alam, Hasan B, Li, Yongqing

“…Peptidylarginine deiminases (PADs) are a group of enzymes that catalyze post-translational modifications of proteins by converting arginine residues into…”
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Early single-dose exosome treatment improves neurologic outcomes in a 7-day swine model of traumatic brain injury and hemorrhagic shock by Williams, Aaron M., Wu, Zhenyu, Bhatti, Umar F., Biesterveld, Ben E., Kemp, Michael T., Wakam, Glenn K., Vercruysse, Claire A., Chtraklin, Kiril, Siddiqui, Ali Z., Pickell, Zachary, Dekker, Simone E., Tian, Yuzi, Liu, Baoling, Li, Yongqing, Buller, Benjamin, Alam, Hasan B.

“…Early single-dose treatment with human mesenchymal stem cell-derived exosomes promotes neuroprotection and promotes blood-brain barrier integrity in models of…”
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Prolonging the zone 1 aortic occlusion time to 4 hours using a partial resuscitative endovascular balloon in a swine model by Ho, Jessie W., Jin, Guang, Nguyen, Jessica, Keeney-Bonthrone, Toby P., Diaz-Perez, Dariel A., Dawood, Zaiba Shafik, Kemp, Michael T., Alam, Jenna S., Gauger, Megan A., Shaikh, Aleezeh, Chtraklin, Kiril, Liu, Baoling, Alam, Hasan B.

“…The clinical usage of the resuscitative endovascular balloon occlusion of the aorta (REBOA) is limited by distal ischemia resulting from complete aortic…”
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Histone Deacetylase Inhibitors: A Novel Strategy for Neuroprotection and Cardioprotection Following Ischemia/Reperfusion Injury by Pickell, Zachary, Williams, Aaron M, Alam, Hasan B, Hsu, Cindy H

“…Ischemia/reperfusion injury is a complex molecular cascade that causes deleterious cellular damage and organ dysfunction. Stroke, sudden cardiac arrest, and…”
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Changing Demographics of the American Population by Halaweish, Ihab, MD, Alam, Hasan B., MD

“…Since 1950, the United States has been in the midst of a profound demographic change: the rapid aging of the population. The baby boom generation began turning…”
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Modulation of Acetylation : Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock by Li, Yongqing, Alam, Hasan B.

“…Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histone and nonhistone proteins and in regulating fundamental cellular…”
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Citrullinated Histone H3 Mediates Sepsis-Induced Lung Injury Through Activating Caspase-1 Dependent Inflammasome Pathway by Tian, Yuzi, Li, Patrick, Wu, Zhenyu, Deng, Qiufang, Pan, Baihong, Stringer, Kathleen A, Alam, Hasan B, Standiford, Theodore J, Li, Yongqing

“…Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection that often results in acute lung injury (ALI)/acute…”
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Derivation and Validation of a Novel Severity Classification for Intraoperative Adverse Events by Kaafarani, Haytham M.A., MD, MPH, Mavros, Michael N., MD, Hwabejire, John, MD, MPH, Fagenholz, Peter, MD, Yeh, Daniel D., MD, FACS, Demoya, Marc, MD, King, David R., MD, FACS, Alam, Hasan B., MD, FACS, Chang, Yuchiao, PhD, Hutter, Matthew, MD, MPH, FACS, Antonelli, Donna, BS, CPHQ, Gervasini, Alice, RN, PhD, Velmahos, George C., MD, PhD, FACS

“…Background There is currently no systematic approach to evaluating the severity of intraoperative adverse events (iAEs). Study Design A 3-phase project was…”
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Pain-associated respiratory failure in chest trauma by Ahn, Young, Görlinger, Klaus, Alam, Hasan B, Eikermann, Matthias

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New Developments in Fluid Resuscitation by Alam, Hasan B., MD, Rhee, Peter, MD, MPH

“…Hemorrhagic shock is the leading cause of death in civilian and military trauma. Effective hemorrhage control and optimal resuscitation are the main goals in…”
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Early Resuscitation with Fresh Frozen Plasma for Traumatic Brain Injury Combined with Hemorrhagic Shock Improves Neurologic Recovery by Halaweish, Ihab, MD, Bambakidis, Ted, MS, He, Wei, MD, Linzel, Durk, MD, Chang, Zhigang, MD, Srinivasan, Ashok, MD, Dekker, Simone E., BSc, Liu, Baoling, MD, Li, Yongqing, MD, PhD, Alam, Hasan B., MD, FACS

“…Background We have shown that early administration of fresh frozen plasma (FFP) reduces the size of brain lesions 6 hours after injury in a large animal model…”
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Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock by Li, Yongqing, MD, PhD, Liu, Baoling, MD, Fukudome, Eugene Y., MD, Lu, Jenifer, BS, Chong, Wei, MD, PhD, Jin, Guang, MD, PhD, Liu, Zhengcai, MD, PhD, Velmahos, George C., MD, PhD, deMoya, Marc, MD, King, David R., MD, Alam, Hasan B., MD, FACS

“…Background Circulating proteins may serve as biomarkers for the early diagnosis and treatment of shock. We have recently demonstrated that treatment with…”
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Inhibition of histone deacetylase 6 restores intestinal tight junction in hemorrhagic shock by Chang, Zhigang, Li, Yongqing, He, Wei, Liu, Baoling, Duan, Xiuzhen, Halaweish, Ihab, Bambakidis, Ted, Pan, Baihong, Liang, Yingjian, Nikolian, Vahagn C, Georgoff, Patrick, Alam, Hasan B

“…We recently discovered that Tubastatin-A, a histone deacetylase (HDAC6) inhibitor, can improve survival in a rodent model of hemorrhagic shock (HS), but…”
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Fresh Frozen Plasma Modulates Brain Gene Expression in a Swine Model of Traumatic Brain Injury and Shock: A Network Analysis by Sillesen, Martin, MD, Phd, Bambakidis, Theodore, Msc, Dekker, Simone, MD, Li, Yongqing, MD, PhD, Alam, Hasan B., MD, FACS

“…Abstract Background Resuscitation with Fresh Frozen Plasma (FFP) decreases brain lesion size and swelling in a swine model of Traumatic Brain Injury (TBI) and…”
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Compliance with Recommended Care at Trauma Centers: Association with Patient Outcomes by Shafi, Shahid, MD, MPH, FACS, Barnes, Sunni A., PhD, Rayan, Nadine, MHA, Kudyakov, Rustam, MD, Foreman, Michael, MD, FACS, Cryer, H. Gil, MD, PhD, FACS, Alam, Hasan B., MD, FACS, Hoff, William, MD, FACS, Holcomb, John, MD, FACS

“…Background State health departments and the American College of Surgeons focus on the availability of optimal resources to designate hospitals as trauma…”
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