Search Results - "Alakhov, V Y"

Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion by BATRAKOVA, E. V, LI, S, ELMQUIST, W. F, MILLER, D. W, ALAKHOV, V. Y, KABANOV, A. V

“…This paper, for the first time, demonstrates that exposure of cells to the poly(ethylene oxide)-poly(propylene oxide) block copolymer, Pluronic P85, results in…”
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Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents by NGUYEN, H.-K, LEMIEUX, P, VINOGRADOV, S. V, GEBHART, C. L, GUERIN, N, PARADIS, G, BRONICH, T. K, ALAKHOV, V. Y, KABANOV, A. V

“…Cationic copolymers consisting of polycations linked to non-ionic polymers are evaluated as non-viral gene delivery systems. These copolymers are known to…”
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Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles : in vivo evaluation of anti-cancer activity by BATRAKOVA, E. V, DORODNYCH, T. Y, KLINSKII, E. Y, KLIUSHNENKOVA, E. N, SHEMCHUKOVA, O. B, GONCHAROVA, O. N, ARJAKOV, S. A, ALAKHOV, V. Y, KABANOV, A. V

“…The chemosensitising effects of poly(ethylene oxide)-poly(propylene oxide)-poly-(ethylene oxide) (PEO-PPO-PEO) block copolymers (Pluronic) in…”
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Polyethyleneimine grafted with pluronic P85 enhances Ku86 antisense delivery and the ionizing radiation treatment efficacy in vivo by BELENKOV, A. I, ALAKHOV, V. Y, KABANOV, A. V, VINOGRADOV, S. V, PANASCI, L. C, MONIA, B. P, CHOW, T. Y. K

“…In an effort to improve the efficacy of antisense delivery, we evaluated polyethyleneimine (PEI, 2 kDa) alone or grafted with nonionic amphiphilic block…”
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Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization by Batrakova, E V, Li, S, Vinogradov, S V, Alakhov, V Y, Miller, D W, Kabanov, A V

“…Pluronic block copolymer, P85, inhibits the P-glycoprotein (Pgp) drug efflux system and increases the permeability of a broad spectrum of drugs in the…”
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Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies by Batrakova, E V, Miller, D W, Li, S, Alakhov, V Y, Kabanov, A V, Elmquist, W F

“…Drug delivery across the blood-brain barrier is limited by several mechanisms. One important mechanism is drug efflux, mediated by several transport proteins,…”
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Block and Graft Copolymers and Nanogel™ Copolymer Networks for DNA Delivery into Cell by Lemieux, P., Vinogradov, S., Gebhart, C., Guerin, N., Paradis, G., Nguyen, H.-K., Ochietti, B., Suzdaltseva, Y., Bartakova, E., Bronich, T., St-Pierre, Y., Alakhov, V., Kabanov, A.

“…AbstractSelf-assembling complexes from nucleic acids and synthetic polymers are evaluated for plasmid and oligonucleotide (oligo) delivery. Polycations having…”
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Micelle Formation and Solubilization of Fluorescent Probes in Poly(oxyethylene-b-oxypropylene-b-oxyethylene) Solutions by Kabanov, Alexander V, Nazarova, Irina R, Astafieva, Irina V, Batrakova, Elena V, Alakhov, Valery Yu, Yaroslavov, Alexander A, Kabanov, Victor A

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Pluronic ® block copolymers as novel polymer therapeutics for drug and gene delivery by Kabanov, Alexander V, Batrakova, Elena V, Alakhov, Valery Yu

“…Pluronic ® block copolymers are found to be an efficient drug delivery system with multiple effects. The incorporation of drugs into the core of the micelles…”
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Pluronic micelles as a tool for low-molecular compound vector delivery into a cell: effect of Staphylococcus aureus enterotoxin B on cell loading with micelle incorporated fluorescent dye by Kabanov, A V, Slepnev, V I, Kuznetsova, L E, Batrakova, E V, Alakhov VYu, Melik-Nubarov, N S, Sveshnikov, P G, Kabanov, V A

“…Micelles of pluronic P85 (poly(oxyethylene)-poly(oxypropylene) block copolymer) are used as microcontainers for in vitro delivery of fluorescein into Jurkat…”
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Pluronic ® block copolymers for overcoming drug resistance in cancer by Kabanov, Alexander V, Batrakova, Elena V, Alakhov, Valery Yu

“…Pluronic ® block copolymers have been used extensively in a variety of pharmaceutical formulations including delivery of low molecular mass drugs and…”
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Pluronic block copolymers in drug delivery: from micellar nanocontainers to biological response modifiers by Kabanov, Alexander V, Alakhov, Valery Yu

“…Pluronic block copolymers are recognized pharmaceutical excipients listed in the US and British Pharmacopoeia. The incorporation of drugs into Pluronic…”
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Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells by Batrakova, Elena V, Li, Shu, Alakhov, Valery Yu, Miller, Donald W, Kabanov, Alexander V

“…Pluronic block copolymer P85 was shown to inhibit the P-glycoprotein (Pgp) drug efflux system and to increase the permeability of a broad spectrum of drugs in…”
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Effect of pluronic P85 on ATPase activity of drug efflux transporters by Batrakova, Elena V, Li, Shu, Li, Yili, Alakhov, Valery Yu, Kabanov, Alexander V

“…Pluronic block copolymers are potent sensitizers of multi-drug resistant (MDR) cancer cells. The sensitization effect by Pluronics is a result of two processes…”
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Pluronic block copolymers alter apoptotic signal transduction of doxorubicin in drug-resistant cancer cells by Minko, Tamara, Batrakova, Elena V., Li, Shu, Li, Yili, Pakunlu, Refika I., Alakhov, Valery Yu, Kabanov, Alexander V.

“…Pluronic block copolymer P85 (P85) sensitizes multidrug resistant (MDR) cancer cells resulting in the increase of cytotoxic activity of antineoplastic agents…”
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An essential relationship between ATP depletion and chemosensitizing activity of Pluronic ® block copolymers by Kabanov, Alexander V., Batrakova, Elena V., Yu. Alakhov, Valery

“…Pluronic ® block copolymers are known to sensitize multidrug resistant (MDR) tumors with respect to various anticancer agents, particularly, anthracycline…”
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Fatty acid acylated antibodies against virus suppress its reproduction in cells by Kabanov, A.V., Ovcharenko, A.V., Melik-Hubarov, N.S., Bannikov, A.I., Alakhov, V.Yu, Kiselev, V.I., Sveshnikov, P.G., Kiselev, O.I., Levashov, A.V., Severin, E.S.

“…A method for suppression of virus reproduction in cells using fatty acylated antiviral antibodies, which in contrast to non-modified antibodies are capable of…”
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Cell-free translation in reversed micelles by Nametkin, Sergey N., Kolosov, Michael I., Ovodov, Sergey Yu, Alexandrov, Alexander N., Levashov, Andrey V., Alakhov, Valery Yu, Kabanov, Alexander V.

“…Cell-free translation in reversed micelles (RM) of surfactants in organic solvents is demonstrated using as an example the synthesis of human interleukin-2 by…”
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The effect of the nonionic block copolymer pluronic P85 on gene expression in mouse muscle and antigen-presenting cells by Gaymalov, Zagit Z, Yang, Zhihui, Pisarev, Vladimir M, Alakhov, Valery Yu, Kabanov, Alexander V

“…Abstract DNA vaccines can be greatly improved by polymer agents that simultaneously increase transgene expression and activate immunity. We describe here…”
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Transcriptional Activation of Gene Expression by Pluronic Block Copolymers in Stably and Transiently Transfected Cells by Sriadibhatla, Srikanth, Yang, Zhihui, Gebhart, Catherine, Alakhov, Valery Yu, Kabanov, Alexander

“…Amphiphilic block copolymers of poly(ethylene oxide) and poly(propylene oxide) (Pluronics) enhance gene expression, but the mechanism remains unclear. We…”
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