Search Results - "Alajmi, Mohammed F"
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In silico exploration of deep-sea fungal metabolites as inhibitor of Ebola and Marburg VP35 and VP40
Published in PloS one (25-07-2024)“…VP30 and VP40 proteins of Ebola and Marburg viruses have been recognized as potential targets for antiviral drug development due to their essential roles in…”
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Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study
Published in Saudi pharmaceutical journal (01-03-2019)“…Despite high anti-HBV efficacies, while the nucleoside analogs (e.g., lamivudine) lead to the emergence of drug-resistance, interferons (e.g., IFN-α causes…”
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3
Determination of chloramphenicol in biological matrices by solid-phase membrane micro-tip extraction and capillary electrophoresis
Published in Biomedical chromatography (01-12-2016)“…Solid‐phase membrane micro‐tip extraction (SPMMTE) and capillary electrophoresis (CE) methods were developed and validated for analysis of chloramphenicol in…”
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Structural Analysis and Conformational Dynamics of STN1 Gene Mutations Involved in Coat Plus Syndrome
Published in Frontiers in molecular biosciences (12-06-2019)“…The human CST complex (CTC1-STN1-TEN1) is associated with telomere functions including genome stability. We have systemically analyzed the sequence of STN and…”
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5
Inhibition of hepatitis B virus activities by Rhazya stricta ‑derived acacetin and acetyl‑β‑carboline
Published in Experimental and therapeutic medicine (01-07-2023)“…Hepatitis B virus (HBV) causes acute and chronic liver diseases, leading to cirrhosis and hepatocellular carcinoma. Although direct-acting nucleoside analogs,…”
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New terpenic and phenolic compounds from Suaeda monoica reverse oxidative and apoptotic damages in human endothelial cells
Published in Saudi pharmaceutical journal (01-10-2021)“…Elevation in hyperglycemia-associated methylglyoxal level can trigger vascular endothelial cells oxidative stress and apoptosis. The present work assesses the…”
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Corrigendum to “New terpenic and phenolic compounds from Suaeda monoica reverse oxidative and apoptotic damages in human endothelial cells”. [Saudi Pharm. J. 29(10) (2021) 1102–1111]
Published in Saudi pharmaceutical journal (01-12-2021)“…[This corrects the article DOI: 10.1016/j.jsps.2021.08.007.]…”
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Oncoglabrinol C, a new flavan from Oncocalyx glabratus protects endothelial cells against oxidative stress and apoptosis, and modulates hepatic CYP3A4 activity
Published in Saudi pharmaceutical journal (01-06-2020)“…Active herbal or natural compounds have high chemical diversity and specificity than synthetic drugs. Recently, we have validated the hypoglycemic salutation…”
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Theoretical and experimental study on lipophilicity and wound healing activity of ginger compounds
Published in Asian Pacific journal of tropical biomedicine (01-04-2014)“…Objective:To correlate the chromatographic and computational method to calculate lipophilicity of selected ginger compounds and to observe the effects of log P…”
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Functional implications of pH-induced conformational changes in the Sphingosine kinase 1
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (15-01-2020)“…Sphingosine kinase 1 (SphK1) catalyzes the conversion of sphingosine to sphingosine-1-phosphate that acts as a bioactive signalling molecule, and regulates…”
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The anti‐hepatitis B virus therapeutic potential of anthraquinones derived from Aloe vera
Published in Phytotherapy research (01-11-2019)“…Although the approved hepatitis B virus (HBV)‐polymerase inhibitors (e.g., lamivudine) often lead to drug‐resistance, several natural products have shown…”
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Molecular docking and ADMET studies of halogenated metabolites from marine sponges as inhibitors of wild-type and mutants PBP2 in Neisseria gonorrhoeae
Published in Journal of biomolecular structure & dynamics (13-12-2023)“…Gonorrhoea is a sexually transmitted infection (STI) caused by the bacteria . Gonorrhoea symptoms can vary, although roughly 50% of women and 10% of men…”
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Identification and evaluation of glutathione conjugate gamma-l-glutamyl-l-cysteine for improved drug delivery to the brain
Published in Journal of biomolecular structure & dynamics (12-08-2020)“…Glutathione (GU), an endogenous antioxidant tripeptide, is frequently transferred in the human brain through N-methyl-d-aspartate receptor (NMDAR), profusely…”
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Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: Towards therapeutic management of Alzheimer's disease
Published in Journal of biomolecular structure & dynamics (01-09-2020)“…Microtubule affinity regulating kinase 4 (MARK4) plays essential role in the tau-assisted regulation of microtubule dynamics. Over expression of MARK4 causes…”
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Chiral HPLC Separation and Modeling of Four Stereomers of DL-Leucine-DL-Tryptophan Dipeptide on Amylose Chiral Column
Published in Chirality (New York, N.Y.) (01-09-2016)“…Chiral high‐performance liquid chromatography (HPLC) separation and modeling of four stereomers of DL‐leucine‐tryptophan DL‐dipeptide on AmyCoat‐RP column are…”
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16
Inhibition of hepatitis B virus activities by Rhazya stricta-derived acacetin and acetyl-[beta]-carboline
Published in Experimental and therapeutic medicine (01-07-2023)“…Hepatitis B virus (HBV) causes acute and chronic liver diseases, leading to cirrhosis and hepatocellular carcinoma. Although direct-acting nucleoside analogs,…”
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Cover Image, Volume 28, Issue 9
Published in Chirality (New York, N.Y.) (01-09-2016)Get full text
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