Search Results - "Alaiwa, Mahmoud H. Abou"

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung by Pezzulo, Alejandro A., Tang, Xiao Xiao, Hoegger, Mark J., Abou Alaiwa, Mahmoud H., Ramachandran, Shyam, Moninger, Thomas O., Karp, Phillip H., Wohlford-Lenane, Christine L., Haagsman, Henk P., van Eijk, Martin, Bánfi, Botond, Horswill, Alexander R., Stoltz, David A., McCray, Paul B., Welsh, Michael J., Zabner, Joseph

“…In a porcine cystic fibrosis model, lack of cystic fibrosis transmembrane conductance regulator (CFTR) is shown to result in acidification of airway surface…”
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Gel-forming mucins form distinct morphologic structures in airways by Ostedgaard, Lynda S., Moninger, Thomas O., McMenimen, James D., Sawin, Nicholas M., Parker, Connor P., Thornell, Ian M., Powers, Linda S., Gansemer, Nicholas D., Bouzek, Drake C., Cook, Daniel P., Meyerholz, David K., Alaiwa, Mahmoud H. Abou, Stoltz, David A., Welsh, Michael J.

“…Gel-forming mucins, the primary macromolecular components of airway mucus, facilitate airway clearance by mucociliary transport. In cystic fibrosis (CF)…”
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pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37 by Alaiwa, Mahmoud H. Abou, Reznikov, Leah R., Gansemer, Nicholas D., Sheets, Kelsey A., Horswill, Alexander R., Stoltz, David A., Zabner, Joseph, Welsh, Michael J.

“…Significance Although lungs are continuously bombarded by bacteria, pulmonary defense mechanisms normally keep them sterile. Those defenses include a complex…”
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Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling by Mao, Suifang, Shah, Alok S., Moninger, Thomas O., Ostedgaard, Lynda S., Lu, Lin, Tang, Xiao Xiao, Thornell, Ian M., Reznikov, Leah R., Ernst, Sarah E., Karp, Philip H., Tan, Ping, Keshavjee, Shaf, Alaiwa, Mahmoud H. Abou, Welsh, Michael J.

“…Differentiated airway epithelia produce sonic hedgehog (SHH), which is found in the thin layer of liquid covering the airway surface. Although previous studies…”
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Tromethamine improves mucociliary clearance in cystic fibrosis pigs by Ash, Jamison J., Hilkin, Brieanna M., Gansemer, Nicholas D., Hoffman, Eric A., Zabner, Joseph, Stoltz, David A., Abou Alaiwa, Mahmoud H.

“…In cystic fibrosis (CF), the loss of cystic fibrosis transmembrane conductance regulator (CFTR) mediated Cl− and HCO3− secretion across the epithelium…”
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Mucus strands from submucosal glands initiate mucociliary transport of large particles by Fischer, Anthony J, Pino-Argumedo, Maria I, Hilkin, Brieanna M, Shanrock, Cullen R, Gansemer, Nicholas D, Chaly, Anna L, Zarei, Keyan, Allen, Patrick D, Ostedgaard, Lynda S, Hoffman, Eric A, Stoltz, David A, Welsh, Michael J, Abou Alaiwa, Mahmoud H

“…Mucus produced by submucosal glands is a key component of respiratory mucociliary transport (MCT). When it emerges from submucosal gland ducts, mucus forms…”
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Polarized AAVR expression determines infectivity by AAV gene therapy vectors by Hamilton, Bradley A., Li, Xiaopeng, Pezzulo, Alejandro A., Abou Alaiwa, Mahmoud H., Zabner, Joseph

“…Adeno-associated virus (AAV) has been investigated to transfer the cystic fibrosis transmembrane conductance regulator ( CFTR ) to airways. Inhaled AAV2- CFTR…”
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Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs by Pino-Argumedo, Maria I, Fischer, Anthony J, Hilkin, Brieanna M, Gansemer, Nicholas D, Allen, Patrick D, Hoffman, Eric A, Stoltz, David A, Welsh, Michael J, Abou Alaiwa, Mahmoud H

“…SignificanceIn many lung diseases, increased amounts of and/or abnormal mucus impair mucociliary clearance, a key defense against inhaled and aspirated…”
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Early Lung Disease Exhibits Bacteria-Dependent and -Independent Abnormalities in Cystic Fibrosis Pigs by Bouzek, Drake C, Abou Alaiwa, Mahmoud H, Adam, Ryan J, Pezzulo, Alejandro A, Reznikov, Leah R, Cook, Daniel P, Aguilar Pescozo, Maria I, Ten Eyck, Patrick, Wu, Chaorong, Gross, Thomas J, Hornick, Douglas B, Hoffman, Eric A, Meyerholz, David K, Stoltz, David A

“…Although it is clear that cystic fibrosis (CF) airway disease begins at a very young age, the early and subsequent steps in disease pathogenesis and the…”
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Mucociliary Transport in Healthy and Cystic Fibrosis Pig Airways by Xie, Yuliang, Ostedgaard, Lynda, Abou Alaiwa, Mahmoud H, Lu, Lin, Fischer, Anthony J, Stoltz, David A

“…Cystic fibrosis (CF) lung disease is the major cause of morbidity and mortality in people with CF. Abnormal mucociliary transport has been the leading…”
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Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid by Vargas Buonfiglio, Luis G, Mudunkotuwa, Imali A, Abou Alaiwa, Mahmoud H, Vanegas Calderón, Oriana G, Borcherding, Jennifer A, Gerke, Alicia K, Zabner, Joseph, Grassian, Vicki H, Comellas, Alejandro P

“…Sustained exposure to ambient particulate matter (PM) is a global cause of mortality. Coal fly ash (CFA) is a byproduct of coal combustion and is a source of…”
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Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs by Stoltz, David A, Rokhlina, Tatiana, Ernst, Sarah E, Pezzulo, Alejandro A, Ostedgaard, Lynda S, Karp, Philip H, Samuel, Melissa S, Reznikov, Leah R, Rector, Michael V, Gansemer, Nicholas D, Bouzek, Drake C, Abou Alaiwa, Mahmoud H, Hoegger, Mark J, Ludwig, Paula S, Taft, Peter J, Wallen, Tanner J, Wohlford-Lenane, Christine, McMenimen, James D, Chen, Jeng-Haur, Bogan, Katrina L, Adam, Ryan J, Hornick, Emma E, Nelson, 4th, George A, Hoffman, Eric A, Chang, Eugene H, Zabner, Joseph, McCray, Jr, Paul B, Prather, Randall S, Meyerholz, David K, Welsh, Michael J

“…Cystic fibrosis (CF) pigs develop disease with features remarkably similar to those in people with CF, including exocrine pancreatic destruction, focal biliary…”
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Air Trapping and Airflow Obstruction in Newborn Cystic Fibrosis Piglets by ADAM, Ryan J, MICHALSKI, Andrew S, DIWAKAR, Amit, OCHS, Matthias, REINHARDT, Joseph M, HOFFMAN, Eric A, BEICHEL, Reinhard R, MEYERHOLZ, David K, STOLTZ, David A, BAUER, Christian, ABOU ALAIWA, Mahmoud H, CROSS, Thomas J, AWADALLA, Maged S, BOUZEK, Drake C, GANSEMER, Nicholas D, TAFT, Peter J, HOEGGER, Mark J

“…Air trapping and airflow obstruction are being increasingly identified in infants with cystic fibrosis. These findings are commonly attributed to airway…”
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Cystic Fibrosis Carrier States Are Associated With More Severe Cases of Bronchiectasis by Miller, Aaron C, Harris, Logan M, Winthrop, Kevin L, Cavanaugh, Joseph E, Abou Alaiwa, Mahmoud H, Hornick, Douglas B, Stoltz, David A, Polgreen, Philip M

“…Abstract Background People with cystic fibrosis (CF) are at increased risk for bronchiectasis, and several reports suggest that CF carriers may also be at…”
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CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes by Steines, Benjamin, Dickey, David D, Bergen, Jamie, Excoffon, Katherine Jda, Weinstein, John R, Li, Xiaopeng, Yan, Ziying, Abou Alaiwa, Mahmoud H, Shah, Viral S, Bouzek, Drake C, Powers, Linda S, Gansemer, Nicholas D, Ostedgaard, Lynda S, Engelhardt, John F, Stoltz, David A, Welsh, Michael J, Sinn, Patrick L, Schaffer, David V, Zabner, Joseph

“…The physiological components that contribute to cystic fibrosis (CF) lung disease are steadily being elucidated. Gene therapy could potentially correct these…”
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Postnatal airway growth in cystic fibrosis piglets by Adam, Ryan J, Abou Alaiwa, Mahmoud H, Bouzek, Drake C, Cook, Daniel P, Gansemer, Nicholas D, Taft, Peter J, Powers, Linda S, Stroik, Mallory R, Hoegger, Mark J, McMenimen, James D, Hoffman, Eric A, Zabner, Joseph, Welsh, Michael J, Meyerholz, David K, Stoltz, David A

“…Mutations in the gene encoding the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) anion channel cause CF. The leading cause of death in the CF…”
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Early Airway Structural Changes in Cystic Fibrosis Pigs as a Determinant of Particle Distribution and Deposition by Awadalla, Maged, Miyawaki, Shinjiro, Abou Alaiwa, Mahmoud H., Adam, Ryan J., Bouzek, Drake C., Michalski, Andrew S., Fuld, Matthew K., Reynolds, Karen J., Hoffman, Eric A., Lin, Ching-Long, Stoltz, David A.

“…The pathogenesis of cystic fibrosis (CF) airway disease is not well understood. A porcine CF model was recently generated, and these animals develop lung…”
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Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis by Abou Alaiwa, Mahmoud H, Launspach, Jan L, Grogan, Brenda, Carter, Suzanne, Zabner, Joseph, Stoltz, David A, Singh, Pradeep K, McKone, Edward F, Welsh, Michael J

“…Disruption of cystic fibrosis transmembrane conductance regulator (CFTR) anion channel function causes cystic fibrosis (CF), and lung disease produces most of…”
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Repurposing tromethamine as inhaled therapy to treat CF airway disease by Abou Alaiwa, Mahmoud H, Launspach, Janice L, Sheets, Kelsey A, Rivera, Jade A, Gansemer, Nicholas D, Taft, Peter J, Thorne, Peter S, Welsh, Michael J, Stoltz, David A, Zabner, Joseph

“…In cystic fibrosis (CF), loss of CF transmembrane conductance regulator (CFTR) anion channel activity causes airway surface liquid (ASL) pH to become acidic,…”
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Risk for Dehydration and Fluid and Electrolyte Disorders Among Cystic Fibrosis Carriers by Lee, Sulyun, Harris, Logan M., Miller, Aaron C., Cavanaugh, Joseph E., Nizar, Jonathan M., Simmering, Jacob E., Abou Alaiwa, Mahmoud H., Polgreen, Linnea A., Polgreen, Philip M.

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