Search Results - "Alain, Tommy"

Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 h before COVID-19 clinical tests and 96 h before hospitalizations by D'Aoust, Patrick M., Graber, Tyson E., Mercier, Elisabeth, Montpetit, Danika, Alexandrov, Ilya, Neault, Nafisa, Baig, Aiman Tariq, Mayne, Janice, Zhang, Xu, Alain, Tommy, Servos, Mark R., Srikanthan, Nivetha, MacKenzie, Malcolm, Figeys, Daniel, Manuel, Douglas, Jüni, Peter, MacKenzie, Alex E., Delatolla, Robert

“…Curtailing the Spring 2020 COVID-19 surge required sweeping and stringent interventions by governments across the world. Wastewater-based COVID-19 epidemiology…”
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mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation by Morita, Masahiro, Gravel, Simon-Pierre, Chénard, Valérie, Sikström, Kristina, Zheng, Liang, Alain, Tommy, Gandin, Valentina, Avizonis, Daina, Arguello, Meztli, Zakaria, Chadi, McLaughlan, Shannon, Nouet, Yann, Pause, Arnim, Pollak, Michael, Gottlieb, Eyal, Larsson, Ola, St-Pierre, Julie, Topisirovic, Ivan, Sonenberg, Nahum

“…mRNA translation is thought to be the most energy-consuming process in the cell. Translation and energy metabolism are dysregulated in a variety of diseases…”
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Transcriptional profiling of macrophages reveals distinct parasite stage-driven signatures during early infection by Leishmania donovani by Chaparro, Visnu, Graber, Tyson E., Alain, Tommy, Jaramillo, Maritza

“…Macrophages undergo swift changes in mRNA abundance upon pathogen invasion. Herein we describe early remodelling of the macrophage transcriptome during…”
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Ionizing Radiation and Translation Control: A Link to Radiation Hormesis? by Kabilan, Usha, Graber, Tyson E, Alain, Tommy, Klokov, Dmitry

“…Protein synthesis, or mRNA translation, is one of the most energy-consuming functions in cells. Translation of mRNA into proteins is thus highly regulated by…”
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La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1) by Fonseca, Bruno D., Zakaria, Chadi, Jia, Jian-Jun, Graber, Tyson E., Svitkin, Yuri, Tahmasebi, Soroush, Healy, Danielle, Hoang, Huy-Dung, Jensen, Jacob M., Diao, Ilo T., Lussier, Alexandre, Dajadian, Christopher, Padmanabhan, Niranjan, Wang, Walter, Matta-Camacho, Edna, Hearnden, Jaclyn, Smith, Ewan M., Tsukumo, Yoshinori, Yanagiya, Akiko, Morita, Masahiro, Petroulakis, Emmanuel, González, Jose L., Hernández, Greco, Alain, Tommy, Damgaard, Christian K.

“…The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of protein synthesis. The best studied targets of mTORC1 in translation are the…”
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Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma by Beug, Shawn T., Beauregard, Caroline E., Healy, Cristin, Sanda, Tarun, St-Jean, Martine, Chabot, Janelle, Walker, Danielle E., Mohan, Aditya, Earl, Nathalie, Lun, Xueqing, Senger, Donna L., Robbins, Stephen M., Staeheli, Peter, Forsyth, Peter A., Alain, Tommy, LaCasse, Eric C., Korneluk, Robert G.

“…Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-α-induced killing while simultaneously…”
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Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3 by Tsukumo, Yoshinori, Alain, Tommy, Fonseca, Bruno D., Nadon, Robert, Sonenberg, Nahum

“…Targeting mTORC1 is a highly promising strategy in cancer therapy. Suppression of mTORC1 activity leads to rapid dephosphorylation of eIF4E-binding proteins…”
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La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs by Lahr, Roni M, Fonseca, Bruno D, Ciotti, Gabrielle E, Al-Ashtal, Hiba A, Jia, Jian-Jun, Niklaus, Marius R, Blagden, Sarah P, Alain, Tommy, Berman, Andrea J

“…The 5'terminal oligopyrimidine (5'TOP) motif is a -regulatory RNA element located immediately downstream of the 7-methylguanosine [m G] cap of TOP mRNAs, which…”
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Translational Control of Entrainment and Synchrony of the Suprachiasmatic Circadian Clock by mTOR/4E-BP1 Signaling by Cao, Ruifeng, Robinson, Barry, Xu, Haiyan, Gkogkas, Christos, Khoutorsky, Arkady, Alain, Tommy, Yanagiya, Akiko, Nevarko, Tatiana, Liu, Andrew C., Amir, Shimon, Sonenberg, Nahum

“…Protein synthesis is critical for circadian clock function, but little is known of how translational regulation controls the master pacemaker in mammals, the…”
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Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer by Lee, Won Suk, Lee, Seung Joon, Lee, Hye Jin, Yang, Hannah, Go, Eun-Jin, Gansukh, Enkhtaivan, Song, Ki-Hoon, Xiang, Xiao, Park, Dong Guk, Alain, Tommy, Chon, Hong Jae, Kim, Chan

“…The route of oncolytic virotherapy is pivotal for immunotherapeutic efficacy in advanced cancers. In this preclinical study, an oncolytic reovirus (RC402) is…”
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Distinct perturbation of the translatome by the antidiabetic drug metformin by Larsson, Ola, Morita, Masahiro, Topisirovic, Ivan, Alain, Tommy, Blouin, Marie-Jose, Pollak, Michael, Sonenberg, Nahum

“…Metformin has been reported to lower cancer incidence among type Il diabetics. Metformin exhibits antiproliferative and antineoplastic effects associated with…”
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Cap-binding protein 4EHP effects translation silencing by microRNAs by Chapat, Clément, Jafarnejad, Seyed Mehdi, Matta-Camacho, Edna, Hesketh, Geoffrey G., Gelbart, Idit A., Attig, Jan, Gkogkas, Christos G., Alain, Tommy, Stern-Ginossar, Noam, Fabian, Marc R., Gingras, Anne-Claude, Duchaine, Thomas F., Sonenberg, Nahum

“…MicroRNAs (miRNAs) play critical roles in a broad variety of biological processes by inhibiting translation initiation and by destabilizing target mRNAs. The…”
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eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies by Alain, Tommy, Morita, Masahiro, Fonseca, Bruno D, Yanagiya, Akiko, Siddiqui, Nadeem, Bhat, Mamatha, Zammit, Domenick, Marcus, Victoria, Metrakos, Peter, Voyer, Lucie-Anne, Gandin, Valentina, Liu, Yi, Topisirovic, Ivan, Sonenberg, Nahum

“…Active-site mTOR inhibitors (asTORi) hold great promise for targeting dysregulated mTOR signaling in cancer. Because of the multifaceted nature of mTORC1…”
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LARP1 on TOP of ribosome production by Fonseca, Bruno D., Lahr, Roni M., Damgaard, Christian K., Alain, Tommy, Berman, Andrea J.

“…The ribosome is an essential unit of all living organisms that commands protein synthesis, ultimately fuelling cell growth (accumulation of cell mass) and cell…”
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Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds by Malone, Kyle, Dugas, Melanie, Earl, Nathalie, Alain, Tommy, LaCasse, Eric C., Beug, Shawn T.

“…Smac mimetic compounds (SMCs) are small molecule drugs that sensitize cancer cells to TNF-α-induced cell death and have multiple immunostimulatory effects…”
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Identification of Novel Regulators of Radiosensitivity Using High-Throughput Genetic Screening by Tamaddondoust, Rosette N, Wong, Alicia, Chandrashekhar, Megha, Azzam, Edouard I, Alain, Tommy, Wang, Yi

“…The biological impact of ionizing radiation (IR) on humans depends not only on the physical properties and absorbed dose of radiation but also on the unique…”
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Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies by Azad, Taha, Rezaei, Reza, Singaravelu, Ragunath, Pelin, Adrian, Boulton, Stephen, Petryk, Julia, Onsu, Kemal Alper, Martin, Nikolas T., Hoskin, Victoria, Ghahremani, Mina, Marotel, Marie, Marius, Ricardo, He, Xiaohong, Crupi, Mathieu J. F., Hoang, Huy-Dung, Nik-Akhtar, Abolfazl, Ahmadi, Mahsa, Zamani, Nika Kooshki, Golshani, Ashkan, Alain, Tommy, Greer, Peter, Ardolino, Michele, Dickinson, Bryan C., Tai, Lee-Hwa, Ilkow, Carolina S., Bell, John C.

“…The large coding potential of vaccinia virus (VV) vectors is a defining feature. However, limited regulatory switches are available to control viral…”
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Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale by Gandin, Valentina, Sikström, Kristina, Alain, Tommy, Morita, Masahiro, McLaughlan, Shannon, Larsson, Ola, Topisirovic, Ivan

“…mRNA translation plays a central role in the regulation of gene expression and represents the most energy consuming process in mammalian cells. Accordingly,…”
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Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling by Fonseca, Bruno D., Diering, Graham H., Bidinosti, Michael A., Dalal, Kush, Alain, Tommy, Balgi, Aruna D., Forestieri, Roberto, Nodwell, Matt, Rajadurai, Charles V., Gunaratnam, Cynthia, Tee, Andrew R., Duong, Franck, Andersen, Raymond J., Orlowski, John, Numata, Masayuki, Sonenberg, Nahum, Roberge, Michel

“…Mammalian target of rapamycin complex 1 (mTORC1) signaling is frequently dysregulated in cancer. Inhibition of mTORC1 is thus regarded as a promising strategy…”
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A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development by Morita, Masahiro, Ler, Lian Wee, Fabian, Marc R., Siddiqui, Nadeem, Mullin, Michael, Henderson, Valerie C., Alain, Tommy, Fonseca, Bruno D., Karashchuk, Galina, Bennett, Christopher F., Kabuta, Tomohiro, Higashi, Shinji, Larsson, Ola, Topisirovic, Ivan, Smith, Robert J., Gingras, Anne-Claude, Sonenberg, Nahum

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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