Grading of Fatty Liver Based on Computed Tomography Hounsfield Unit Values versus Ultrasonography Grading

Grading of Fatty Liver Based on Computed Tomography Hounsfield Unit Values versus Ultrasonography Grading

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) ranges from hepatic steatosis to nonalcoholic steatohepatitis and may lead to liver cirrhosis. This study aimed to assess the feasibility of numerical grading MASLD using noncontrast computed tomography (NCCT). Methods: In...

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Published in:Gastroenterology insights Vol. 15; no. 3; pp. 588 - 598
Main Authors: Alshoabi, Sultan Abdulwadoud, Alharbi, Reyan Mohammed, Algohani, Rufaydah Bader, Alahmadi, Shahad Abdullah, Ahmed, Maryam, Faqeeh, Samah F., Alahmadi, Dalal, Qurashi, Abdulaziz A., Alhazmi, Fahad H., Alrehaili, Rakan Mohammed, Almughathawi, Abdulrahman Khalil
Format: Journal Article
Language:English
Published: Boston MDPI AG 01-09-2024
Subjects:
Alcoholism
Biopsy
computed tomography Hounsfield units (CT HU)
Diabetes
grading of MASLD
Liver cirrhosis
liver density (HU)
Liver diseases
Males
metabolic dysfunction-associated steatotic liver disease (MASLD)
Metabolism
Patients
Spleen
Tomography
Ultrasonic imaging
ultrasonography grading of MASLD
Variance analysis
Saudi Arabia
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Summary:Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) ranges from hepatic steatosis to nonalcoholic steatohepatitis and may lead to liver cirrhosis. This study aimed to assess the feasibility of numerical grading MASLD using noncontrast computed tomography (NCCT). Methods: In a retrospective study of 166 patients diagnosed with MASLD between June 2020 and January 2024, MASLD was graded by ultrasonography, and liver density was measured on NCCT. The MASLD grades and NCCT densities were compared. Results: The MASLD grades were distributed as follows: grade 0 (n = 79, 47.6%), grade 2 (n = 48, 28.9%), grade 1 (n = 25, 15.1%), and grade 3 (n = 14, 8.4%). The mean liver density was 57.75 Hounsfield units (HU) ± 6.18 (range: 48.9–78.2), 51.1 HU ± 4.7 (range: 41.4–59.7), 39.3 ± 6.4 (range: 21.4–48.9), and 22.87 ± 7.5 (range: 12–36.4) in the grade 0, grade 1, grade 2, and grade 3 patients, respectively. An analysis of variance test showed significant variance in the distribution of mean liver density in the different MASLD grades (p < 0.001). Conclusions: After ultrasonography diagnosis of MASLD, NCCT offers an objective, numerical, and calculable method for MASLD grading that is available for radiologists, radiologic technologists, and interested physicians away from experience dependence. NCCT determined that grade 2 had a specific density from 36.4 to 41.4 HU that significantly overlapped with grade 1 (41.4–48.9) HU and with grade 3 (21.4–36.4 HU). Grade 1 showed a significant overlap with the normal liver (48.9–59.7 HU).
ISSN:2036-7422
2036-7414
2036-7422
DOI:10.3390/gastroent15030043