Search Results - "Alagarsamy, V"

An overview of quinazolines: Pharmacological significance and recent developments by Alagarsamy, V., Chitra, K., Saravanan, G., Solomon, V. Raja, Sulthana, M.T., Narendhar, B.

“…Most of the drugs and pharmacologically relevant molecules possess heterocyclic ring structures and presence of hetero atoms or groupings divulges privileged…”
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Drug Repurposing: An Effective Tool in Modern Drug Discovery by Kulkarni, V. S., Alagarsamy, V., Solomon, V. R., Jose, P. A., Murugesan, S.

“…Drug repurposing is using an existing drug for a new treatment that was not indicated before. It has received immense attention during the COVID-19 pandemic…”
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Synthesis of New 1-Substituted-3-(3-(2-Chlorophenyl)-4-Oxo-3,4-Dihydrobenzopyrimidin-2-Ylamino)Isothioureas as Anti-HIV and Antibacterial Agents by Narendhar, B., Chitra, K., Alagarsamy, V.

“…In this study, a new benzopyrimidine analog was designed and synthesized by substituting 3-nitrophenyl ring and thiosemicarbazide nucleus at N-3 and C-2…”
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Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents by Alagarsamy, V, Raja Solomon, V, Dhanabal, K

“…A variety of novel 3-phenyl-2-substituted-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-phenyl-3H-quinazolin-4-one with…”
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Parametric studies on dry sliding wear behaviour of Al-7075 alloy matrix composite using S/N ratio and ANOVA analysis by Alagarsamy, S V, Ravichandran, M

“…Al7075/10 wt% TiO2 alloy composite has been fabricated by the stir casting method to investigate the influence of wear parameters. The microstructure of the…”
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Current trends and future perspectives on dental nanomaterials – An overview of nanotechnology strategies in dentistry by Umapathy, Vidhya Rekha, Natarajan, Prabhu Manickam, SumathiJones, C., Swamikannu, Bhuminathan, Johnson, W.M.S., Alagarsamy, V., Milon, Ashequr Rahman

“…The field of nanotechnology or nanoscience encompasses research and development in the applied sciences at the atomic or molecular levels and has a huge impact…”
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3D Printing Manufacturing Techniques, Materials, and Applications: An Overview by Srinivasan, D., Meignanamoorthy, M., Ravichandran, M., Mohanavel, V., Alagarsamy, S. V., Chanakyan, C., Sakthivelu, S., Karthick, Alagar, Prabhu, T. Ram, Rajkumar, S.

“…3D printing, also called additive manufacturing (AM), is a method of creating 3D solid parts from a digital document. By utilizing additive routes, the…”
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In Silico Screening of Some Active Phytochemicals to Identify Promising Inhibitors Against SARS-CoV-2 Targets by Alagarsamy, V, Solomon, V Raja, Murugesan, S, Sundar, P Shyam, Muzaffar-Ur-Rehman, M D, Chandu, A, Aishwarya, A Dharshini, Narendhar, B, Sulthana, M T, Ravikumar, V

“…There are very few small-molecule drug candidates developed against SARS-CoV-2 that have been revealed since the epidemic began in November 2019. The typical…”
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Design, Synthesis, and Structure–Activity Relationships of Novel N-Substituted-5-phenyl-[1,2,4]triazolo[1,5-c]quinazolin-2-amine for Their Anti-HIV and Antibacterial Activities by Alagarsamy, V., Narendhar, B., Chitra, K., Sriram, D., Sarvanan, G., Solomon, V. Raja

“…A new series of N -substituted-5-phenyl-[1,2,4]triazolo[1,5- c ]quinazolin-2-amine ( XIa–o ) were synthesized by the nucleophilic substitution reaction of…”
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Synthesis and pharmacological investigation of novel 4 -benzyl -1 -substituted -4H-[1,2,4 ]triazolo [4,3 -a]quinazolin -5 -ones as new class of H1-antihistaminic agents by ALAGARSAMY, V, SOLOMON, V. R, MURUGAN, M

“…A series of novel 1-substituted-4-benzyl-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones were synthesized by the cyclization of…”
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Pharmacophore modelling-based drug repurposing approaches for monkeypox therapeutics by Alagarsamy, V., Shyam Sundar, P., Raja Solomon, V., Narendhar, B., Sulthana, M. T., Rohitha, Kotha, Dhanwar, Sangeeta, Dharshini Aishwarya, A., Murugesan, S.

“…Monkeypox is a zoonotic viral disease that mainly affects tropical rainforest regions of central and west Africa, with sporadic exportations to other places…”
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Computational Search for Potential COVID-19 Drugs from Ayurvedic Medicinal Plants to Identify Potential Inhibitors against SARS-CoV-2 Targets by Alagarsamy, V, Solomon, V Raja, Sundar, P Shyam, Kulkarni, Vishaka S, Sulthana, M T, Aishwarya, A Dharshini, Narendhar, B, Murugesan, S

“…To date, very few small drug molecules are used for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has been discovered since the epidemic…”
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Isolation, Functionalization, In Silico Investigation, and Synthesis of 1,8-Cineole Analog as Antitubercular Agent Targeting InhA by Sabarees, G., Gouthaman, S., Alagarsamy, V., Velmurugan, V., Solomon, V. Raja

“…A desirable and established target for creating antituberculosis drug lead molecules is the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase…”
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Parametric Optimization of Mechanical Properties via FSW on AA5052 Using Taguchi Based Grey Relational Analysis by CHANAKYAN, C., SIVASANKAR, S., MEIGNANAMOORTHY, M., ALAGARSAMY, S. V.

“…The Friction stir processing benefits of aluminium composites contain advanced exploration in the region of aluminium alloy Friction Stir Welding - FSW. The…”
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Study of Wear Behavior on AA6061 Reinforced with Hybrid Ceramic Composites through Optimization by Shabbir, Omar, Alagarsamy, S. V., Krishnamurthy, C., Nagaraj, A., Singh, Pradeep Kumar, Ketema Sida, Sisay

“…This present work uses the three main components for alloying, silver nitrate, aluminium nitride, and titanium diboride. Stir casting was used to make AA 6061…”
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Design and Synthesis of 1-Substituted-4-(4-Nitrophenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-ones as a New Class of Antihistaminic Agents by Gobinath, M., Subramanian, N., Alagarsamy, V., Nivedhitha, S., Solomon, Viswas Raja

“…Some new 1-substituted-4-(4-nitrophenyl)-[1,2,4]triazolo[4,3- a ]quinazolin-5(4 H )-ones were synthesized and screened for their H 1 -antihistaminic activity…”
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Synthesis and Pharmacological Evaluation of 3‐propyl‐2‐substitutedamino‐3H‐quinazolin‐4‐ones as Analgesic and Anti‐Inflammatory Agents by Sheorey, R. V., Thangathiruppathy, A., Alagarsamy, V.

“…A variety of novel 3‐propyl‐2‐substitutedamino‐quinazolin‐4(3H)‐ones were synthesized by reacting the amino group of 2‐hydrazino‐3‐propyl quinazolin‐4(3H)‐one…”
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Design, Synthesis, and Structure–Activity Relationships of Novel 1-(Substituted)-2-Methyl-3-(4-Oxo-2-Methylquinazolin-3(4H)-yl) Isothioureas for Their Anti-HIV and Antibacterial Activities by Alagarsamy, V., Sulthana, M. T., Chitra, K., Solomon, V. Raja, Saravanan, G.

“…In this study, a novel quinazolinone analogue was designed and synthesized by substituting the thiourea group and phenyl ring at N-3 and C-2 positions of the…”
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Design and Synthesis of Novel 3-(Phenyl)-2-(3-substituted propylthio) Quinazolin-4-(3H)-ones as a New Class of H1-Antihistaminic Agents by Alagarsamy, V., Parthiban, P.

“…A series of novel 3‐(phenyl)‐2‐(3‐substituted propylthio) quinazolin‐4‐(3H)‐ones were synthesized by the reaction of 2‐(3‐bromopropylthio)‐3‐(phenyl)…”
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AntiHIV, antitubercular and antibacterial activities of novel 1-substituted-3-(3-(4-methylphenyl)-4-oxo-3,4-dihydrobenzopyrimidin-2-yl amino) isothioureas by Narendhar B, Chitra K, Alagarsamy V

“…In this research, substituted thiosemicarbazide group was placed at 2nd position & 4-methylphenyl group was placed at 3rd position of condensed pyrimidine…”
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