Search Results - "Aladesuyi Arogundade, Olubankole"
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Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization
Published in Acta neuropathologica communications (15-02-2021)“…Nucleolar stress has been implicated in the pathology and disease pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration…”
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Adolescent impulsivity as a sex-dependent and subtype-dependent predictor of impulsivity, alcohol drinking and dopamine D 2 receptor expression in adult rats
Published in Addiction biology (01-03-2019)“…Impulsivity is a personality trait associated with a heightened risk for drug use and other psychiatric conditions. Because impulsivity-related disorders…”
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Journal Article -
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Adolescent impulsivity as a sex‐dependent and subtype‐dependent predictor of impulsivity, alcohol drinking and dopamine D2 receptor expression in adult rats
Published in Addiction biology (01-03-2019)“…Impulsivity is a personality trait associated with a heightened risk for drug use and other psychiatric conditions. Because impulsivity‐related disorders…”
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Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition
Published in Nature cell biology (01-09-2022)“…While acetylated, RNA-binding-deficient TDP-43 reversibly phase separates within nuclei into complex droplets (anisosomes) comprised of TDP-43-containing…”
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Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis
Published in Acta neuropathologica (01-12-2021)“…Amyotrophic lateral sclerosis is a progressive fatal neurodegenerative disease caused by loss of motor neurons and characterized neuropathologically in almost…”
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Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision
Published in Proceedings of the National Academy of Sciences - PNAS (23-04-2024)“…Efforts to genetically reverse C9orf72 pathology have been hampered by our incomplete understanding of the regulation of this complex locus. We generated five…”
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TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination
Published in The Journal of cell biology (06-09-2021)“…Cholesterol metabolism operates autonomously within the central nervous system (CNS), where the majority of cholesterol resides in myelin. We demonstrate that…”
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Antisense RNA foci are associated with nucleoli and TDP-43 mislocalization in C9orf72-ALS/FTD: a quantitative study
Published in Acta neuropathologica (01-03-2019)Get full text
Journal Article -
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Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures
Published in Cell systems (17-02-2021)“…Induced pluripotent stem cell (iPSC)-derived neural cultures from amyotrophic lateral sclerosis (ALS) patients can model disease phenotypes. However,…”
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Nucleolar Stress and RNA Toxicity in C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Published 01-01-2020“…In 2011, two independent groups discovered that hexanucleotide repeat expansion in C9orf72 cause amyotrophic lateral sclerosis and frontotemporal dementia…”
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Dissertation -
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Adolescent impulsivity as a sex- and subtype-dependent predictor of impulsivity, alcohol drinking, and dopamine D2 receptor expression in adult rats
Published in Addiction biology (05-12-2017)“…Impulsivity is a personality trait associated with a heightened risk for drug use and other psychiatric conditions. Because impulsivity-related disorders…”
Get full text
Journal Article