Search Results - "Alabdullah, Muslim"

The silibinin-loaded Zein-β cyclodextrin nano-carriers (SZBC-NCs) as a novel selective cancer cell drug delivery system in HT-29 cell line by al Alabdullah, Muslim Abdulrazzaq A., Goodarzi, Mohammad Taghi, Homayouni Tabrizi, Masoud

“…Entrapping phytochemical bioactive compounds into nano-structured biocompatible polymers has been successfully utilized for improving cancer treatment…”
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Molecular disruption of DNA polymerase β for platinum sensitisation and synthetic lethality in epithelial ovarian cancers by Ali, Reem, Alblihy, Adel, Miligy, Islam M., Alabdullah, Muslim L., Alsaleem, Mansour, Toss, Michael S., Algethami, Mashael, Abdel-Fatah, Tarek, Moseley, Paul, Chan, Stephen, Mongan, Nigel P., Narayan, Satya, Rakha, Emad A., Madhusudan, Srinivasan

“…Targeting PARP1 [Poly(ADP-Ribose) Polymerase 1] for synthetic lethality is a new strategy for BRCA germ-line mutated or platinum sensitive ovarian cancers…”
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RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers by Alblihy, Adel, Alabdullah, Muslim L., Toss, Michael S., Algethami, Mashael, Mongan, Nigel P., Rakha, Emad A., Madhusudan, Srinivasan

“…Intrinsic or acquired resistance seriously limits the use of platinating agents in advanced epithelial ovarian cancers. Increased DNA repair capacity is a key…”
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Clinicopathological and Functional Evaluation Reveal NBS1 as a Predictor of Platinum Resistance in Epithelial Ovarian Cancers by Alblihy, Adel, Alabdullah, Muslim L, Ali, Reem, Algethami, Mashael, Toss, Michael S, Mongan, Nigel P, Rakha, Emad A, Madhusudan, Srinivasan

“…Platinum resistance seriously impacts on the survival outcomes of patients with ovarian cancers. Platinum-induced DNA damage is processed through DNA repair…”
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ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity by Ali, Reem, Alabdullah, Muslim, Miligy, Islam, Normatova, Makhliyo, Babaei-Jadidi, Roya, Nateri, Abdolrahman S, Rakha, Emad A, Madhusudan, Srinivasan

“…Ataxia-telegiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), and p85α are key tumour suppressors. Whether ATM regulates PTEN expression and…”
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Exploring the Role of Cell Signalling and Dna Damage Pathways in Primary Surgically Resected Ovarian Cancer by Alabdullah, Muslim

“…Background: Ovarian cancer (OC) is the most lethal gynaecologic malignancy. It is a heterogeneous disease at the molecular, histological and clinical levels…”
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PARP1 blockade is synthetically lethal in XRCC1 deficient sporadic epithelial ovarian cancers by Ali, Reem, Alabdullah, Muslim, Alblihy, Adel, Miligy, Islam, Mesquita, Katia A., Chan, Stephen YT, Moseley, Paul, Rakha, Emad A., Madhusudan, Srinivasan

“…PARP1 inhibitor (Niraparib, Olaparib, Rucaparib) maintenance therapy improves progression-free survival in platinum sensitive sporadic epithelial ovarian…”
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ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers by Mesquita, Katia A., Alabdullah, Muslim, Griffin, Michaela, Toss, Michael S., Fatah, Tarek M.A. Abdel, Alblihy, Adel, Moseley, Paul, Chan, Stephen Y.T., Rakha, Emad A., Madhusudan, Srinivasan

“…PARP inhibitor maintenance therapy in platinum sensitive sporadic ovarian cancers improves progression free survival. However, biomarker for synthetic…”
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Molecular disruption of DNA polymerase [beta] for platinum sensitisation and synthetic lethality in epithelial ovarian cancers by Ali, Reem, Alblihy, Adel, Miligy, Islam M, Alabdullah, Muslim L, Alsaleem, Mansour, Toss, Michael S, Algethami, Mashael, Abdel-Fatah, Tarek, Moseley, Paul, Chan, Stephen, Mongan, Nigel P, Narayan, Satya, Rakha, Emad A, Madhusudan, Srinivasan

“…Targeting PARP1 [Poly(ADP-Ribose) Polymerase 1] for synthetic lethality is a new strategy for BRCA germ-line mutated or platinum sensitive ovarian cancers…”
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Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers by Ali, Reem, Alabdullah, Muslim, Algethami, Mashael, Alblihy, Adel, Miligy, Islam, Shoqafi, Ahmed, Mesquita, Katia A, Abdel-Fatah, Tarek, Chan, Stephen Yt, Chiang, Pei Wen, Mongan, Nigel P, Rakha, Emad A, Tomkinson, Alan E, Madhusudan, Srinivasan

“…The human ligases (LIG1, LIG3 and LIG4) are essential for the maintenance of genomic integrity by catalysing the formation of phosphodiester bonds between…”
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