Search Results - "Alaa El-Sisi"

Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-κB-NLRP3 pathway in hepatic ischemia/reperfusion injury by El-Sisi, Alaa El-Din El-Sayed, Sokar, Samia Salim, Shebl, Abdelhadi Mohamed, Mohamed, Dina Zakaria, Abu-Risha, Sally El-Sayed

“…The Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB)/NLRP3 inflammasome signaling pathway is essential in the pathogenesis of hepatic ischemia/…”
Get full text

Targeting autophagy to modulate hepatic ischemia/reperfusion injury: A comparative study between octreotide and melatonin as autophagy modulators through AMPK/PI3K/AKT/mTOR/ULK1 and Keap1/Nrf2 signaling pathways in rats by Mohamed, Dina Zakaria, El-Sisi, Alaa El-Din El-Sayed, Sokar, Samia Salim, Shebl, Abdelhadi Mohamed, Abu-Risha, Sally El-Sayed

“…Hepatic ischemia-reperfusion (HIR) injury is a common pathophysiological process in many clinical settings. This study was designed to compare the protective…”
Get full text

Numerical investigation of the monotonic behavior of strengthened Steel-Concrete composite girders by Alsharari, Fahad, El-Zohairy, Ayman, Salim, Hani, El-Din El-Sisi, Alaa

“…•The behavior of post-tensioned steel–concrete composite girders is numerically studied.•Finite element model was developed and validated using experimental…”
Get full text

JNK inhibitor and ferroptosis modulator as possible therapeutic modalities in Alzheimer disease (AD) by Zakaria, Sherin, Ibrahim, Nashwa, Abdo, Walied, E. El-Sisi, Alaa

“…Alzheimer disease (AD) is among the most prevalent neurodegenerative diseases globally, marked by cognitive and behavioral disruptions. Ferroptosis is a form…”
Get full text

Deformation and load transfer analysis of staggered composite-steel lap joints subjected to progressive damage by El-Sisi, Alaa El-Din A., El-Emam, Hesham M., Salim, Hani A., Sallam, Hossam El-Din M.

“…•Composite-steel double lapped joints were studied experimentally and numerically.•There is a good agreement between the experimental data and predicted…”
Get full text

Progressive failure analysis of woven and non‐woven CFRP composite/steel bolted joints by El‐Sisi, Alaa El‐Din A., Salim, Hani A., Gomaa, Shady A., El‐Feky, Mohamed H.

“…Abstract Due to recent advancements in textile fabrication, woven fabric reinforcements are used in composite structures as an alternative to traditional…”
Get full text

Structural behavior of hybrid CFRP/steel bolted staggered joints by El-Sisi, Alaa El-Din, Sallam, Hossam El-Din, Salim, Hani A., El-Husseiny, Osama M.

“…•Experimental tests were performed to study the composite joints behaviors.•3D finite element model was developed and validated with experimental works.•The…”
Get full text

Metformin potentiates the chemotherapeutic effects of doxorubicin on 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5b] pyridine‐induced Mammary Carcinoma in rats by Salim, Elsayed, El‐Sisi, Alaa El‐Din, Sokar, Samia, EL‐Sayad, Magda, Moussa, Ethar

“…This study was carried out to evaluate the antitumor activity of Metformin (Met) and its impending utility to potentiate the chemotherapeutic action of…”
Get full text

Effect of the Progressive Failure of Shear Connectors on the Behavior of Steel-Reinforced Concrete Composite Girders by Alsharari, Fahad, El-Sisi, Alaa El-Din, Mutnbak, Mohammed, Salim, Hani, El-Zohairy, Ayman

“…Pre-stressed steel-concrete composite beams are widely used in bridges around the world. Loads during the service life of bridges may cause failure in the form…”
Get full text

Damage Detection in One- and Two-Dimensional Structures using Residual Error Method by Alshalal, Iqbal, Al Zubaidi, Faten, El-Sisi, Alaa El-Din, Feng, Z.C.

“…Damage detection at the early stages of structural design is crucial to prevent the occurrence of unpredictable failures. The residual error method can be used…”
Get full text

Comparative effects of enalapril versus perindopril on serum levels of leptin and adiponectin in hypertensive patients by Werida, Rehab, Khairat, Ibtsam, Khedr, Lamiaa, El-Sisi, Alaa El-Din

“…Introduction: Abnormal adipokine levels affect blood pressure (BP) regulation. Hypo-adiponectinaemia and hyperleptinaemia were reported in hypertension, little…”
Get full text

Cyclic performance of RC frame joints with drilled openings by Galustanian, Narek, El-Sisi, Alaa El-Din, Panahshahi, Nader, Orton, Sarah, Sobhy, Asmaa

“…The construction industry commonly employs reinforced concrete (RC) beams with utility pipe openings to facilitate the passage of pipes through structures…”
Get full text

Antifibrotic effect of diethylcarbamazine combined with hesperidin against ethanol induced liver fibrosis in rats by El-Sisi, Alaa El-Din El-Sayed, Sokar, Samia Salim, Shebl, Abdelhadi Mohamed, Mohamed, Dina Zakaria

“…Abstract Chronic alcohol consumption leads to extracellular matrix hyperplasia and liver fibrosis with a great role of hepatic stellate cell (HSC) activation…”
Get full text

Effect of atorvastatin and methotrexate on solid Ehrlich tumor by Kabel, Ahmed M., Abdel-Rahman, Mohamed Nabih, El-Sisi, Alaa El-Din E., Haleem, Mahmoud Said, Ezzat, Nadia M., El Rashidy, Mohamed A.

“…Hydroxymethyl glutaryl CoA reductase is the key enzyme in cholesterol synthesis. A relationship was found between cholesterol and the development of many types…”
Get full text

Pre-damage effect on the residual behavior of externally post-tensioned fatigued steel-concrete composite beams by Alsharari, Fahad, El-Zohairy, Ayman, Salim, Hani, El-Din El-Sisi, Alaa

“…Steel-concrete composite beams in highway bridges are susceptible to various types of damage during their service life. These damages can greatly affect the…”
Get full text

Field-testing and numerical simulation of vantage steel bridge by El-Sisi, Alaa El-Din A., El-Husseiny, Osama M., Matar, Ehab B., Sallam, Hossam El-Din M., Salim, Hani A.

“…Several steel bridges in Egypt were built during the late nineteenth to early twentieth centuries. At this time, riveted construction was the method used for…”
Get full text

Targeting MDR‐1 gene expression, BAX/BCL2, caspase‐3, and Ki‐67 by nanoencapsulated imatinib and hesperidin to enhance anticancer activity and ameliorate cardiotoxicity by El‐Sisi, Alaa E., Sokkar, Samia S., Ibrahim, Hanaa A., Hamed, Mohamed F., Abu‐Risha, Sally E.

“…There is a great demand to introduce new approaches into cancer treatment field due to incidence of increased breast cancer all over the world. The current…”
Get full text

Efficient 3D modeling of damage in composite materials by El-Sisi, Alaa El-Din A, El-Emam, Hesham M, Salim, Hani A, Sallam, Hossam El-Din M

“…Due to the complexity of composite material, numerical methods are generally utilized in their analysis and design. Commercial finite element (FE) codes, such…”
Get full text

Quasi-static strength of bridge fingerplates under various design parameters by Mutnbak, Mohammed, Salim, Hani, El-Sisi, Alaa El-Din

“…Fingerplate expansion devices are commonly used to account for movements and rotations of two bridge deck slabs. Under high traffic volumes, these devices…”
Get full text

Celecoxib and omega-3 fatty acids alone and in combination with risperidone affect the behavior and brain biochemistry in amphetamine-induced model of schizophrenia by El-Sayed El-Sisi, Alaa, Sokkar, Samia Salem, El-Sayed El-Sayad, Magda, Sayed Ramadan, Ehab, Osman, Enass Yossef

“…Abstract The implications of oxidative stress and neuro-inflammation in the pathogenesis of schizophrenia have been elucidated. Despite their effectiveness…”
Get full text