Search Results - "AlSharari, Shakir D"

Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse by Toma, Wisam, Kyte, S. Lauren, Bagdas, Deniz, Alkhlaif, Yasmin, Alsharari, Shakir D., Lichtman, Aron H., Chen, Zhi-Jian, Del Fabbro, Egidio, Bigbee, John W., Gewirtz, David A., Damaj, M. Imad

“…Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively extends the progression-free survival of breast, lung, and ovarian cancer…”
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Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: Studies in transgenic mice by AlSharari, Shakir D., Freitas, Kelen, Damaj, M. Imad

“…A growing body of evidence indicates that α7 nicotinic receptor subtypes play an important role in chronic inflammatory and neuropathic pain signaling. In the…”
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Effect of 25-methoxy hispidol A isolated from Poncirus trifoliate against bacteria-induced anxiety and depression by targeting neuroinflammation, oxidative stress and apoptosis in mice by Shal, Bushra, Khan, Adnan, Naveed, Muhammad, Ullah Khan, Naseem, Ihsan-Ul-Haq, D AlSharari, Shakir, Kim, Yeong Shik, Khan, Salman

“…[Display omitted] •25-MHA attenuates bacteria-induced anxiety and depression-like behaviors.•25-MHA prevents neuroinflammation and oxidative stress.•DNA damage…”
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Increased Permeability of the Blood-Brain Barrier in a Diabetic Mouse Model ( Lepr db / db Mice) by Alshammari, Musaad A, Alshehri, Abdulaziz O, Alqahtani, Faleh, Khan, Mohammad R, Bakhrebah, Muhammed A, Alasmari, Fawaz, Alshammari, Tahani K, Alsharari, Shakir D

“…Type 2 Diabetes Mellitus (T2DM) is linked to multiple complications, including cognitive impairment, and the prevalence of memory-related neurodegenerative…”
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Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice by Alsharari, Shakir D, King, Justin R, Nordman, Jacob C, Muldoon, Pretal P, Jackson, Asti, Zhu, Andy Z X, Tyndale, Rachel F, Kabbani, Nadine, Damaj, M Imad

“…Although menthol, a common flavoring additive to cigarettes, has been found to impact the addictive properties of nicotine cigarettes in smokers little is…”
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Clavulanic Acid Improves Memory Dysfunction and Anxiety Behaviors through Upregulating Glutamatergic Transporters in the Nucleus Accumbens of Mice Repeatedly Exposed to Khat Extract by Arab, Amal O, Alasmari, Fawaz, Albaker, Awatif B, Alhazmi, Hassan A, Alameen, Alaa Alnoor, Alagail, Naser M, Alwaeli, Saleh A, Rizwan Ahamad, Syed, AlAsmari, Abdullah F, AlSharari, Shakir D

“…Khat (Catha edulis) is an evergreen shrub whose buds and leaves give a state of delight and euphoria when chewed. Cathinone, an amphetamine-like stimulant that…”
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The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management by Alfarouk, Khalid O, Bashir, Adil H H, Aljarbou, Ahmed N, Ramadan, AbdelRahman M, Muddathir, Abdel Khalig, AlHoufie, Sari T S, Hifny, Abdelhamid, Elhassan, Gamal O, Ibrahim, Muntaser E, Alqahtani, Saad S, AlSharari, Shakir D, Supuran, Claudiu T, Rauch, Cyril, Cardone, Rosa Angela, Reshkin, Stephan J, Fais, Stefano, Harguindey, Salvador

“…(HP) is a facultative anaerobic bacterium. HP is a normal flora having immuno-modulating properties. This bacterium is an example of a microorganism inducing…”
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The potential effect of α7 nicotinic receptors modulation on palatable food-induced dependence-like behaviors by Alameen, Alaa A., AlSharari, Shakir D., Alshammari, Musaad A., Damaj, M.I., Sari, Y.

“…The recent global increase in obesity rates, coupled with excessive palatable food (PF) consumption, has become a serious societal concern. Literature…”
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Therapeutic benefits of quercetin in traumatic brain injury model exposed to cigarette smoke by Alqahtani, Faleh, Mohamed Ali, Yousif S., Almutairi, Mohammed M., Alotaibi, Abdullah F., Imran, Imran, Alshammari, Musaad A, Alshememry, Abdullah K., AlSharari, Shakir D., Albekairi, Thamer H.

“…Scientific evidences reported the deleterious effect of cigarette smoking or passive smoking on brain health particularly cognitive functions, blood–brain…”
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The antinociceptive effects of nicotinic partial agonists varenicline and sazetidine-A in murine acute and tonic pain models by AlSharari, Shakir D, Carroll, F Ivy, McIntosh, J Michael, Damaj, M Imad

“…Nicotinic agonists display a wide-range profile of antinociceptive activity in acute, tonic, and chronic pain models. However, their effectiveness is limited…”
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Effects of novel beta-lactam, MC-100093, and ceftriaxone on astrocytic glutamate transporters and neuroinflammatory factors in nucleus accumbens of C57BL/6 mice exposed to escalated doses of morphine by Sari, Youssef, Swiss, Ghadeer M.S., Alrashedi, Fatin A., Baeshen, Kholoud A., Alshammari, Sultan A., Alsharari, Shakir D., Ali, Nemat, Alasmari, Abdullah F., Alhoshani, Ali, Alameen, Alaa A., Childers, Wayne E., Abou-Gharbia, Magid, Alasmari, Fawaz

“…Chronic exposure to opioids can lead to downregulation of astrocytic glutamate transporter 1 (GLT-1), which regulates the majority of glutamate uptake. Studies…”
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Systemic TNF-α blockade attenuates anxiety and depressive-like behaviors in db/db mice through downregulation of inflammatory signaling in peripheral immune cells by Alshammari, Musaad A., Khan, Mohammad R., Majid Mahmood, Hafiz, Alshehri, Abdulaziz O., Alasmari, Fawaz F., Alqahtani, Faleh M., Alasmari, Abdullah F., Alsharari, Shakir D., Alhossan, Abdulaziz, Ahmad, Sheikh F., Nadeem, Ahmed, Alshammari, Tahani K.

“…Research studies have indicated that the comorbidity burden of mood disorders and obesity is reasonably high. Insulin signaling has been shown to modulate…”
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Novel insights on the effect of nicotine in a murine colitis model by AlSharari, Shakir D, Akbarali, Hamid I, Abdullah, Rehab A, Shahab, Omer, Auttachoat, Wimolnut, Ferreira, Gabriela A, White, Kimber L, Lichtman, Aron H, Cabral, Guy A, Damaj, M Imad

“…Studies showed that nicotine has a positive influence on symptoms of ulcerative colitis. In the present study, we explored the effect of nicotine treatment…”
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Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model by AlSharari, Shakir D., Bagdas, Deniz, Akbarali, Hamid I., Lichtman, Patraic A., Raborn, Erinn S., Cabral, Guy A., Carroll, F. Ivy, McGee, Elizabeth A., Damaj, M. Imad

“…α7 nicotinic acetylcholine receptors (nAChRs) play an important role in vagus nerve-based cholinergic anti-inflammatory effects. This study was designed to…”
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Mucoadhesive In Situ Rectal Gel Loaded with Rifampicin: Strategy to Improve Bioavailability and Alleviate Liver Toxicity by Al-Joufi, Fakhria, Elmowafy, Mohammed, Alruwaili, Nabil K, Alharbi, Khalid S, Shalaby, Khaled, Alsharari, Shakir D, Ali, Hazim M

“…Although it is a front-line in tuberculosis treatment, rifampicin (RF) exhibits poor oral bioavailability and hepatotoxicity. Rectal mucoadhesive and in situ…”
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Investigating Behavioral and Neuronal Changes in Adolescent Mice Following Prenatal Exposure to Electronic Cigarette (E-Cigarette) Vapor Containing Nicotine by AlHarthi, Alaa, Alasmari, Fawaz, AlSharari, Shakir D, Alrasheed, Nouf M, Alshammari, Musaad A, Alshammari, Tahani K

“…A substantial percentage of pregnant smokers stop using traditional cigarettes and switch to alternative nicotine-related products such as e-cigarettes…”
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Neuroinflammation and Neurometabolomic Profiling in Fentanyl Overdose Mouse Model Treated with Novel β-Lactam, MC-100093, and Ceftriaxone by Alasmari, Mohammed S, Alasmari, Fawaz, Alsharari, Shakir D, Alasmari, Abdullah F, Ali, Nemat, Ahamad, Syed Rizwan, Alghamdi, Abdullah M, Kadi, Aban A, Hammad, Alaa M, Ali, Yousif S Mohamed, Childers, Wayne E, Abou-Gharbia, Magid, Sari, Youssef

“…Opioid-related deaths are attributed to overdoses, and fentanyl overdose has been on the rise in many parts of the world, including the USA. Glutamate…”
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Effects of Chronic Inhalation of Electronic Cigarette Vapor Containing Nicotine on Neurobehaviors and Pre/Postsynaptic Neuron Markers by Alasmari, Fawaz, Alotibi, Farraj M., Alqahtani, Faleh, Alshammari, Tahani K., Kadi, Aban A., Alghamdi, Abdullah M., Allahem, Bassil S., Alasmari, Abdullah F., Alsharari, Shakir D., Al-Rejaie, Salim S., Alshammari, Musaad A.

“…Nicotine-exposed animal models exhibit neurobehavioral changes linked to impaired synaptic plasticity. Previous studies highlighted alterations in…”
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Nelotanserin, a selective 5-HT2A receptor inverse agonist, attenuates aspects of nicotine withdrawal but not reward in mice by Buzzi, Belle, AlSharari, Shakir D., Walentiny, David M., Damaj, M. Imad

“…Nicotine smoking contributes to many preventable disabilities, diseases and deaths. Targeting nicotine reward and withdrawal is a basis for the majority of…”
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The role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain by Bagdas, Deniz, AlSharari, Shakir D., Freitas, Kelen, Tracy, Matthew, Damaj, M. Imad

“…The aim of the present study was to determine the impact of α5 nicotinic acetylcholine receptor (nAChR) subunit deletion in the mouse on the development and…”
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