Search Results - "Al Temimi, Abbas H. K"

Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis by Temimi, Abbas H. K. Al, Reddy, Y. Vijayendar, White, Paul B., Guo, Hong, Qian, Ping, Mecinović, Jasmin

“…Histone lysine methyltransferases (KMTs) represent an important class of epigenetic enzymes that play essential roles in regulation of gene expression in…”
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Importance of the main chain of lysine for histone lysine methyltransferase catalysis by Al Temimi, Abbas H K, Teeuwen, Ruben S, Tran, Vu, Altunc, Arthur J, Lenstra, Danny C, Ren, Wansheng, Qian, Ping, Guo, Hong, Mecinović, Jasmin

“…Histone lysine methyltransferases (KMTs) are biomedicinally important class of epigenetic enzymes that catalyse methylation of lysine residues in histones and…”
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Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases by Al Temimi, Abbas H K, White, Paul B, Mulders, Marcus J M, van der Linden, Nicole G A, Blaauw, Richard H, Wegert, Anita, Rutjes, Floris P J T, Mecinović, Jasmin

“…We report synthesis and enzymatic assays on human histone lysine methyltransferase catalysed methylation of histones that possess lysine and its geometrically…”
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Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis by Temimi, Abbas H. K. Al, Tran, Vu, Teeuwen, Ruben S., Altunc, Arthur J., Amatdjais-Groenen, Helene I. V., White, Paul B., Lenstra, Danny C., Proietti, Giordano, Wang, Yali, Wegert, Anita, Blaauw, Richard H., Qian, Ping, Ren, Wansheng, Guo, Hong, Mecinović, Jasmin

“…Methylation of lysine residues in histone proteins is catalyzed by S -adenosylmethionine (SAM)-dependent histone lysine methyltransferases (KMTs), a genuinely…”
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Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins by Hintzen, Jordi C J, Poater, Jordi, Kumar, Kiran, Al Temimi, Abbas H K, Pieters, Bas J G E, Paton, Robert S, Bickelhaupt, F Matthias, Mecinović, Jasmin

“…Gaining a fundamental insight into the biomolecular recognition of posttranslationally modified histones by epigenetic reader proteins is of crucial importance…”
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Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases by Al Temimi, Abbas H. K., Merx, Jona, van Noortwijk, Christian J., Proietti, Giordano, Buijs, Romano, White, Paul B., Rutjes, Floris P. J. T., Boltje, Thomas J., Mecinović, Jasmin

“…Histone lysine methyltransferases (KMTs) play an important role in epigenetic gene regulation and have emerged as promising targets for drug discovery…”
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γ‑Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones by Al Temimi, Abbas H. K, van der Wekken-de Bruijne, Renate, Proietti, Giordano, Guo, Hong, Qian, Ping, Mecinović, Jasmin

“…Biomedicinally important histone lysine methyltransferases (KMTs) transfer a methyl group from S-adenosylmethionine to lysine residues in histones and other…”
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Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition by Belle, Roman, Al Temimi, Abbas H K, Kumar, Kiran, Pieters, Bas J G E, Tumber, Anthony, Dunford, James E, Johansson, Catrine, Oppermann, Udo, Brown, Tom, Schofield, Christopher J, Hopkinson, Richard J, Paton, Robert S, Kawamura, Akane, Mecinović, Jasmin

“…Histone lysine methylation is regulated by N -methyltransferases, demethylases, and N -methyl lysine binding proteins. Thermodynamic, catalytic and…”
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Lysine Ethylation by Histone Lysine Methyltransferases by Al Temimi, Abbas H. K., Martin, Michael, Meng, Qingxi, Lenstra, Danny C., Qian, Ping, Guo, Hong, Weinhold, Elmar, Mecinović, Jasmin

“…Biomedicinally important histone lysine methyltransferases (KMTs) catalyze the transfer of a methyl group from S‐adenosylmethionine (AdoMet) cosubstrate to…”
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Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation by Pieters, Bas J. G. E, Hintzen, Jordi C. J, Grobben, Yvonne, Al Temimi, Abbas H. K, Kamps, Jos J. A. G, Mecinović, Jasmin

“…Site-specific incorporation of post-translationally modified amino acids into proteins, including histones, has been a subject of great interest for chemical…”
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Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)‑3-Hydroxy‑N ε‑trimethyllysine by Reddy, Y. Vijayendar, Al Temimi, Abbas H. K, White, Paul B, Mecinović, Jasmin

“…Trimethyllysine hydroxylase (TMLH) is an Fe­(II) and 2-oxoglutarate (2OG) dependent oxygenase involved in the biomedically important carnitine biosynthesis…”
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Peptide-Appended Permethylated β‑Cyclodextrins with Hydrophilic and Hydrophobic Spacers by Al Temimi, Abbas H. K, Boltje, Thomas J, Zollinger, Daniel, Rutjes, Floris P. J. T, Feiters, Martin C

“…A novel synthetic methodology, employing a combination of the strain-promoted azide–alkyne cycloaddition and maleimide–thiol reactions, for the preparation of…”
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Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II) by Lenstra, Danny C., Al Temimi, Abbas H.K., Mecinović, Jasmin

“…[Display omitted] Histone lysine methyltransferases G9a and GLP are validated targets for the development of new epigenetic drugs. Most, if not all, inhibitors…”
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LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2 by Wang, Haifeng, Jiang, Danhua, Axelsson, Elin, Lorković, Zdravko J., Montgomery, Sean, Holec, Sarah, Pieters, Bas J.G.E., Al Temimi, Abbas H.K., Mecinović, Jasmin, Berger, Frédéric

“…Heterochromatin Protein 1 (HP1) is a major regulator of chromatin structure and function. In animals, the network of proteins interacting with HP1 is mainly…”
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Investigating the active site of human trimethyllysine hydroxylase by Wang, Yali, Reddy, Y Vijayendar, Al Temimi, Abbas H K, Venselaar, Hanka, Nelissen, Frank H T, Lenstra, Danny C, Mecinović, Jasmin

“…The biologically important carnitine biosynthesis pathway in humans proceeds via four enzymatic steps. The first step in carnitine biosynthesis is catalyzed by…”
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Fluorinated trimethyllysine as a 19 F NMR probe for trimethyllysine hydroxylase catalysis by Vijayendar Reddy, Y, Al Temimi, Abbas H K, Mecinović, Jasmin

“…Trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of N -trimethyllysine in the first step of carnitine biosynthesis in humans. Studies on TMLH…”
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The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis by Al Temimi, Abbas H. K., Amatdjais-Groenen, Helene I. V., Reddy, Y. Vijayendar, Blaauw, Richard H., Guo, Hong, Qian, Ping, Mecinović, Jasmin

“…Histone lysine methyltransferases (KMTs) are biomedically important epigenetic enzymes that catalyze the transfer of methyl group from S -adenosylmethionine to…”
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