Search Results - "Al Shahrani, Mesfer"

Identification of New Mycobacterium tuberculosis Proteasome Inhibitors Using a Knowledge-Based Computational Screening Approach by Almeleebia, Tahani M, Shahrani, Mesfer Al, Alshahrani, Mohammad Y, Ahmad, Irfan, Alkahtani, Abdullah M, Alam, Md Jahoor, Kausar, Mohd Adnan, Saeed, Amir, Saeed, Mohd, Iram, Sana

“…(Mtb) is a deadly tuberculosis (TB)-causing pathogen. The proteasome is vital to the survival of Mtb and is therefore validated as a potential target for…”
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Assessing the potential impact of COVID-19 Omicron variant: Insight through a fractional piecewise model by Li, Xiao-Ping, DarAssi, Mahmoud H., Khan, Muhammad Altaf, Chukwu, C.W., Alshahrani, Mohammad Y., Shahrani, Mesfer Al, Riaz, Muhammad Bilal

“…We consider a new mathematical model for the COVID-19 disease with Omicron variant mutation. We formulate in details the modeling of the problem with omicron…”
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Detection of chikungunya virus in the Southern region, Saudi Arabia by Hakami, Abdulrahim R, Alshamrani, Abdullah A, Alqahtani, Mohamad, Alraey, Yasser, Alhefzi, Razan A, Alasmari, Sultan, Makkawi, Mohamed, Dobie, Gasim, Mir, Mushtaq, Alshahrani, Mohamed, Dera, Ayed, Alfaifi, Mohammed, Al Shahrani, Mesfer, Matari, Ahmad, Asiry, Ali Essa

“…Despite the fact that the chikungunya viral infection is a neglected disease, complications such as hemorrhagic fever, arthritis, and lymphopenia remain a…”
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Hemoglobinopathies: An update on the prevalence trends in Southern Saudi Arabia by Makkawi, Mohammed, Alasmari, Sultan, Hawan, Ali A, Shahrani, Mesfer M. Al, Dera, Ayed A

“…Objectives: To investigate trends in hemoglobinopathies following the establishment of a mandatory premarital screening program (MPMSP) in the southern region…”
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Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson's Disease by Al Shahrani, Mesfer, Heales, Simon, Hargreaves, Iain, Orford, Michael

“…Oxidative stress arises when cellular antioxidant defences become overwhelmed by a surplus generation of reactive oxygen species (ROS). Once this occurs, many…”
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Computational analysis and in vitro evaluation of TMF 104, for its antioxidant, antimicrobial, and anticancer efficacies by Saif, Ahmed, Al Shahrani, Mesfer, Alshehri, Mohammed, Abohassan, Mohammad, Alshehri, Mohammed A., Radhakrishnan, Suresh, Rajagopalan, Prasanna

“…Benzylidene chromanones are small molecules, structurally similar to active phytochemicals. Herein, we report one novel benzylidene chromanone, TMF 104, for…”
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High-throughput virtual screening and preclinical analysis identifies CB-1, a novel potent dual B-Raf/c-Raf inhibitor, effective against wild and mutant variants of B-Raf expression in colorectal carcinoma by Al Shahrani, Mesfer, Abohassan, Mohammad, Y. Alshahrani, Mohammad, Hakami, Abdulrahim R., Rajagopalan, Prasanna

“…Paradoxical Raf activation via Raf dimerization is a major drawback of wild/mutant B-Raf inhibitors. Herein, we report that CB-1 a novel, potent B-Raf/c-Raf…”
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Computational and in vitro characterization of ICY‐5: A potential candidate promoting mitochondrial apoptosis via the c‐MET and STAT3 pathways by Al Shahrani, Mesfer, Balasubramaniam, Meenakshisundaram, Alshahrani, Mohammad Y., Saif, Ahmed, Dera, Ayed A., Alasmari, Sultan, Abohassan, Mohammad, Makkawi, Mohammed, Radhakrishnan, Suresh, Rajagopalan, Prasanna

“…Targeted chemotherapy remains the primary choice in controlling various forms of breast cancer (BC) due to its heterogenous gene expressions in various…”
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Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's by Toomey, Christina E, Heywood, Wendy E, Evans, James R, Lachica, Joanne, Pressey, Sarah N, Foti, Sandrine C, Al Shahrani, Mesfer, D'Sa, Karishma, Hargreaves, Iain P, Heales, Simon, Orford, Michael, Troakes, Claire, Attems, Johannes, Gelpi, Ellen, Palkovits, Miklos, Lashley, Tammaryn, Gentleman, Steve M, Revesz, Tamas, Mills, Kevin, Gandhi, Sonia

“…The molecular drivers of early sporadic Parkinson's disease (PD) remain unclear, and the presence of widespread end stage pathology in late disease masks the…”
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Anticancer efficacy of 3-(4-isopropyl) benzylidene-8-ethoxy, 6-methyl, chroman-4-one (SBL-060), a novel, dual, estrogen receptor-Akt kinase inhibitor in acute myeloid leukemia cells by Shahrani, Mesfer Al, Rajagopalan, Prasanna, Abohassan, Mohammad, Alshahrani, Mohammad, Alraey, Yasser, Gahtani, Reem M, Radhakrishnan, Suresh, Dagreery, Khlood

“…Estrogen receptor (ER) α is expressed in a subset of patient-derived acute myeloid leukemia (AML) cells, whereas Akt is predominantly expressed in most types…”
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Synergistic efficacies of thymoquinone and standard antibiotics against multi-drug resistant isolates by Dera, Ayed A, Ahmad, Irfan, Rajagopalan, Prasanna, Shahrani, Mesfer Al, Saif, Ahmed, Alshahrani, Mohammad Y, Alraey, Yasser, Alamri, Ahmad M, Alasmari, Sultan, Makkawi, Mohammed, Alkhathami, Ali G, Zaman, Gaffar, Hakami, Abdulrahim, Alhefzi, Razan, Alfhili, Mohammad A

“…To explore the antibacterial activity of thymoquinone (TQ), a quinone extracted from . This study was conducted from May 2019 to March 2020 at the Department…”
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Increased mRNA expression of key cytokines among suspected cases of Pneumocystis jirovecii infection by Alshahrani, Mohammad Y, Alfaifi, Mohammed, Al Shahrani, Mesfer, Alshahrani, Abdulaziz S, Alkhathami, Ali G, Dera, Ayed A, Ahmad, Irfan, Wahab, Shadma, Beg, Mirza M A, Hakamy, Ali, Hamid, Mohamed E

“…Pneumocystis pneumonia (PCP) is a fatal infectious disease caused by Pneumocystis jirovecii (PJP). The major factor relevant to morbidity and mortality seems…”
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High-throughput computational screening and in vitro evaluation identifies 5-(4-oxo-4H-3,1-benzoxazin-2-yl)-2-[3-(4-oxo-4H-3,1-benzoxazin-2-yl) phenyl]-1H-isoindole-1,3(2H)-dione (C3), as a novel EGFR-HER2 dual inhibitor in gastric tumors by Shahrani, Mesfer Al, Gahtani, Reem, Abohassan, Mohammad, Alshahrani, Mohammad, Alraey, Yasser, Dera, Ayed, Asiri, Mohammad Rajeh, Rajagopalan, Prasanna

“…Gastric cancers are caused primarily due to the activation and amplification of the EGFR or HER2 kinases resulting in cell proliferation, adhesion,…”
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Impact of Male Obesity on Semen Quality and Serum Sex Hormones by Eskandar, Mamdoh, Al-Asmari, Manal, Babu Chaduvula, Suresh, Al-Shahrani, Mesfer, Al-Sunaidi, Mohammed, Almushait, Mona, Donia, Osman, Al-Fifi, Suliman

“…Introduction. To investigate the association of high Body Mass Index (BMI) with semen parameters and reproductive hormones in men of reproductive age. Setting…”
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Fetomaternal and neonatal outcome of triplet pregnancy. Promising results by Al-Sunaidi, Mohammed, Al-Shahrani, Mesfer S

“…To determine the fetomaternal and neonatal outcomes in triplet pregnancy. A retrospective review of 32 triplet pregnancies between January 2007 to December…”
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Prescribing patterns for acute respiratory infections in primary health care, aseer region, saudi arabia by Al-Khaldi, Yahia M, Diab, Mohamed M A A, Al-Gelban, Khalid S, Al-Asmari, Ali S, Al-Amin, Salaheddin, Al-Shahrani, Mesfer S

“…The objective of this study was to identify the patterns of prescribing for Acute respiratory infections in patients attending primary health care centers in…”
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Identification of second generation benzylidene chromanone analogues as novel, potent DHODH inhibitors in acute myeloid leukemia cells by Abohassan, Mohammad, Al Shahrani, Mesfer, Rajagopalan, Prasanna

“…Dihydroorotate dehydrogenase (DHODH) remains as an active target at the preclinical level against acute myeloid leukemia (AML). Herein we report potent second…”
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Long-Term Heat Stress Exposure Induced Poor Semen Parameters and Testicular Damage in Rats by Increasing Oxidative Stress, Sex Hormone Silencing, and Activation of Intrinsic Testicular Apoptosis [348] by Al-Shahrani, Mesfer Safar

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C-5401331 identified as a novel T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) inhibitor to control acute myeloid leukemia (AML) cell proliferation by Al Shahrani, Mesfer, Gahtani, Reem M., Makkawi, Mohammed

“…T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is a checkpoint protein expressed in exhausted T-cells during cancer scenarios. This…”
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Identification by molecular dynamic simulation and in vitro validation of SISB-A1, N-[1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-yl]-2-[(2-oxo-4-phenyl-2H-chromen-7-yl) oxy], as an inhibitor of the AblT315I mutant kinase to combat imatinib resistance in chronic myeloid leukemia by Al Shahrani, Mesfer, Gahtani, Reem M., Abohassan, Mohammad, Alasmari, Sultan, Makkawi, Mohammed

“…The discovery of imatinib, a specific inhibitor of Abl kinase, revolutionized the therapeutic approach to chronic myeloid leukemia (CML); however, its efficacy…”
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