Assessment of anti-factor Xa activity of enoxaparin for venous thromboembolism prophylaxis in morbidly obese surgical patients

Assessment of anti-factor Xa activity of enoxaparin for venous thromboembolism prophylaxis in morbidly obese surgical patients

Venous thromboembolism (VTE) can be encountered by 60% of hospitalized patients. Anticoagulants have been recommended to reduce the risk of VTE in patients with risk factors. However, no specific dosing recommendations for obese patients are provided in the current practice guidelines. The purpose o...

Full description

Saved in:
Bibliographic Details
Published in:Annals of thoracic medicine Vol. 12; no. 3; pp. 199 - 203
Main Authors: Al Otaib, Nouf, Bootah, Zohour, Al Ammari, Maha A, Aldebasi, Tariq M, Alkatheri, Abdulmalik M, Al Harbi, Shmeylan A, AbuRuz, Salah M, AlBekairy, Abdulkareem M
Format: Journal Article
Language:English
Published: India Medknow Publications & Media Pvt. Ltd 01-07-2017
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects:
Anticoagulants
Body mass index
Clinical medicine
Gastrointestinal surgery
Health risk assessment
Health sciences
Hip joint
Hospitalization
Low molecular weight heparin
obese
Obesity
Original
Pharmaceuticals
Pharmacy
Studies
surgery
Thromboembolism
Thrombosis
venous thromboembolism
weight-based dose
Saudi Arabia
Low molecular weight heparin
venous thromboembolism
weight-based dose
obese
surgery
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Venous thromboembolism (VTE) can be encountered by 60% of hospitalized patients. Anticoagulants have been recommended to reduce the risk of VTE in patients with risk factors. However, no specific dosing recommendations for obese patients are provided in the current practice guidelines. The purpose of this study was to determine the efficacy and safety of weight-based dosing of enoxaparin for VTE prophylaxis among morbidly obese patients undergoing surgery. Adult patients were enrolled if they have a body mass index (BMI) of ≥35 kg/m and were scheduled for surgery. These patients were prescribed enoxaparin (0.5 mg/kg subcutaneously [SC] once daily). Peak anti-factor Xa levels were measured 4 h after the third dose of enoxaparin. The primary outcome measure was to determine whether a weight-based dosing of enoxaparin of 0.5 mg/kg produce the anticipated peak anti-Xa levels (0.2-0.6 IU/m) among obese patients undergoing surgery. Secondary outcomes include the incidence of VTE, the incidence of minor or major bleeding, and the incidence of heparin-induced thrombocytopenia (HIT). Fifty patients were enrolled in the study. The mean age was 53 ± 16 years, 74% of the patients were female. The mean BMI was 40.5 ± 5, and the average enoxaparin dose was 50 ± 9.8 SC daily. Nearly 88% of the patients reached the target anti-factor Xa (0.427 ± 0.17). None of the patients developed HIT or VTE. There was no incidence of major or minor bleeding. Weight-based enoxaparin dose led to the anticipated peak anti-Xa levels (0.2-0.6 IU/mL) in most of the morbidly obese study patients undergoing surgery without any evidence of major side effects. The weight-based dosing of enoxaparin was also effective in preventing VTE in all patients. Although these results are promising, further comparative trials are needed in the setting of morbidly obese surgical patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1817-1737
1998-3557
DOI:10.4103/atm.ATM_31_17