Search Results - "Al Madhoun, Ashraf"

Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality? by Eaaswarkhanth, Muthukrishnan, Al Madhoun, Ashraf, Al-Mulla, Fahd

“…The increasing number of deaths due to the COVID-19 pandemic has raised serious global concerns. Increased testing capacity and ample intensive care…”
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Role of Caveolin-1 in Diabetes and Its Complications by Al-Mulla, Fahd, Nizam, Rasheeba, Al Madhoun, Ashraf, Haddad, Dania

“…It is estimated that in 2017 there were 451 million people with diabetes worldwide. These figures are expected to increase to 693 million by 2045; thus,…”
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SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains by Haddad, Dania, John, Sumi Elsa, Mohammad, Anwar, Hammad, Maha M, Hebbar, Prashantha, Channanath, Arshad, Nizam, Rasheeba, Al-Qabandi, Sarah, Al Madhoun, Ashraf, Alshukry, Abdullah, Ali, Hamad, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this pandemic are strikingly…”
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PKD1 Duplicated regions limit clinical Utility of Whole Exome Sequencing for Genetic Diagnosis of Autosomal Dominant Polycystic Kidney Disease by Ali, Hamad, Al-Mulla, Fahd, Hussain, Naser, Naim, Medhat, Asbeutah, Akram M., AlSahow, Ali, Abu-Farha, Mohamed, Abubaker, Jehad, Al Madhoun, Ashraf, Ahmad, Sajjad, Harris, Peter C.

“…Autosomal dominant polycystic kidney disease (ADPKD) is an inherited monogenic renal disease characterised by the accumulation of clusters of fluid-filled…”
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Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals by Al-Rashed, Fatema, Sindhu, Sardar, Al Madhoun, Ashraf, Ahmad, Zunair, AlMekhled, Dawood, Azim, Rafaat, Al-Kandari, Sarah, Wahid, Maziad Al-Abdul, Al-Mulla, Fahd, Ahmad, Rasheed

“…The role of leukocyte inflammatory markers and toll like receptors (TLRs)2/4 in pathologies associated with elevated resting heart rate (RHR) levels in healthy…”
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Adipose tissue gene expression of CXCL10 and CXCL11 modulates inflammatory markers in obesity: implications for metabolic inflammation and insulin resistance by Kochumon, Shihab, Madhoun, Ashraf Al, Al-Rashed, Fatema, Azim, Rafaat, Al-Ozairi, Ebaa, Al-Mulla, Fahd, Ahmad, Rasheed

“…Background: The CXCL subfamily of chemokines (CXCL9, CXCL10, and CXCL11; angiostatic chemokines) plays a key role in many inflammatory diseases. However, the…”
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Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin by AlKhairi, Irina, Cherian, Preethi, Abu-Farha, Mohamed, Madhoun, Ashraf Al, Nizam, Rasheeba, Melhem, Motasem, Jamal, Mohamed, Al-Sabah, Suleiman, Ali, Hamad, Tuomilehto, Jaakko, Al-Mulla, Fahd, Abubaker, Jehad

“…Type 2 diabetes (T2D) is a growing pandemic associated with metabolic dysregulation and chronic inflammation. Meteorin-like hormone (METRNL) is an adipomyokine…”
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Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells by Al Madhoun, Ashraf, Marafie, Sulaiman K, Haddad, Dania, Melhem, Motasem, Abu-Farha, Mohamed, Ali, Hamad, Sindhu, Sardar, Atari, Maher, Al-Mulla, Fahd

“…Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are a valuable tool in stem cell research due to their high proliferation rate, multi-lineage…”
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Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells by Al Madhoun, Ashraf, Haddad, Dania, Al Tarrah, Mustafa, Jacob, Sindhu, Al-Ali, Waleed, Nizam, Rasheeba, Miranda, Lavina, Al-Rashed, Fatema, Sindhu, Sardar, Ahmad, Rasheed, Bitar, Milad S., Al-Mulla, Fahd

“…The imipramine ONC201 has antiproliferative effects in several cancer cell types and activates integrated stress response pathway associated with the induction…”
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Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology by Arefanian, Hossein, Al Madhoun, Ashraf, Al-Ali, Waleed, Nader, Joelle, Bitar, Milad S., Al-Mulla, Fahd

“…Sarcopenia, a loss of muscle mass and functionality, constitutes a major contributor to disability in diabetes. Hydrogen sulfide (H2S) dynamics and muscle mass…”
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Functionally-focused algorithmic analysis of high resolution microarray-CGH genomic landscapes demonstrates comparable genomic copy number aberrations in MSI and MSS sporadic colorectal cancer by Ali, Hamad, Bitar, Milad S, Al Madhoun, Ashraf, Marafie, Makia, Al-Mulla, Fahd

“…Array-based comparative genomic hybridization (aCGH) emerged as a powerful technology for studying copy number variations at higher resolution in many cancers…”
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Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults by Al-Rashed, Fatema, Sindhu, Sardar, Al Madhoun, Ashraf, Alghaith, Abdulwahab, Azim, Rafaat, Al-Mulla, Fahd, Ahmad, Rasheed

“…Background: Efficient sleep duration and its quality are increasingly recognized as important contributors for maintaining normal body weight. However,…”
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Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study by M. Abdel-Halim, Samy, Madhoun, Ashraf Al, Nizam, Rasheeba, Melhem, Motasem, Cherian, Preethi, Al-Khairi, Irina, Haddad, Dania, Abu-Farha, Mohamed, Abubaker, Jehad, Bitar, Milad S, Al-Mulla, Fahd

“…Adenylate cyclases (ADCYs) catalyze the conversion of ATP to cAMP, an important co-factor in energy homeostasis. Giving ADCYs role in obesity, diabetes and…”
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Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation by Al-Rashed, Fatema, Arefanian, Hossein, Madhoun, Ashraf Al, Bahman, Fatemah, Sindhu, Sardar, AlSaeed, Halemah, Jacob, Texy, Thomas, Reeby, Al-Roub, Areej, Alzaid, Fawaz, Malik, M D Zubbair, Nizam, Rasheeba, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd, Hannun, Yusuf A, Ahmad, Rasheed

“…Non-alcoholic fatty liver disease (NAFLD) is manifested by hepatic steatosis, insulin resistance, hepatocyte death, and systemic inflammation. Obesity induces…”
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Functional Dissection of the NuA4 Histone Acetyltransferase Reveals Its Role as a Genetic Hub and that Eaf1 Is Essential for Complex Integrity by Mitchell, Leslie, Lambert, Jean-Philippe, Gerdes, Maria, Al-Madhoun, Ashraf S., Skerjanc, Ilona S., Figeys, Daniel, Baetz, Kristin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Editorial: Rising stars: Clinical diabetes 2021 by Al Madhoun, Ashraf, Hamasaki, Hidetaka

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Elevated adipose tissue associated IL-2 expression in obesity correlates with metabolic inflammation and insulin resistance by Kochumon, Shihab, Al Madhoun, Ashraf, Al-Rashed, Fatema, Thomas, Reeby, Sindhu, Sardar, Al-Ozairi, Ebaa, Al-Mulla, Fahd, Ahmad, Rasheed

“…Adipose tissue (AT) associated cytokines are involved in the development of chronic low-grade inflammation in obese individuals. IL-2, a pleiotropic cytokine,…”
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New-Generation Glucokinase Activators: Potential Game-Changers in Type 2 Diabetes Treatment by Haddad, Dania, Dsouza, Vanessa Sybil, Al-Mulla, Fahd, Al Madhoun, Ashraf

“…Achieving glycemic control and sustaining functional pancreatic β-cell activity remains an unmet medical need in the treatment of type 2 diabetes mellitus…”
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ROS/TNF-α Crosstalk Triggers the Expression of IL-8 and MCP-1 in Human Monocytic THP-1 Cells via the NF-κB and ERK1/2 Mediated Signaling by Akhter, Nadeem, Wilson, Ajit, Thomas, Reeby, Al-Rashed, Fatema, Kochumon, Shihab, Al-Roub, Areej, Arefanian, Hossein, Al-Madhoun, Ashraf, Al-Mulla, Fahd, Ahmad, Rasheed, Sindhu, Sardar

“…IL-8/MCP-1 act as neutrophil/monocyte chemoattractants, respectively. Oxidative stress emerges as a key player in the pathophysiology of obesity. However, it…”
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75-OR: IL-6R (Trans Signaling) Is a Major Modulator of Reverse Cholesterol Transport in Lipid-Laden Macrophages by ALRASHED, FATEMA, ALZAQQAH, FATEMAH, MADHOUN, ASHRAF AL, ALQABANDI, RAWAN, SINDHU, SARDAR T., ALMULLA, FAHD, AHMAD, RASHEED

“…The onset of obesity is vastly associated with low levels of high-density lipoprotein cholesterol (HDL-C) , which predisposes to cardiovascular diseases…”
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