Determination of coffee extract level in saliva Orthodontic patient
Aim: this study was aimed to find out the pharmacokinetic of caffeine (the active compound in coffee) to determine the elimination half-life, area under the curve and other pharmacokinetic parameters for caffeine after excretion in saliva. Materials and Methods: data were collected from twenty ortho...
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| Published in: | Al-SalamJournal for Medical Science Vol. 2; no. 2; pp. 1 - 6 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Alsalam university college
25-03-2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Aim: this study was aimed to find out the pharmacokinetic of caffeine (the active compound in coffee) to determine the elimination half-life, area under the curve and other pharmacokinetic parameters for caffeine after excretion in saliva. Materials and Methods: data were collected from twenty orthodontic patients wearing fixed appliance treated in AL Noor center for at least 2 months. Each patient took one cup of coffee (100 ml), then salivary sample was collected at 0, 10, 20, 30, 45 min, 1, 2 and 3 hr. then the concentration of caffeine was detected in every sample. Results: The pharmacokinetic results for caffeine were, elimination rate constant was (0.69hr-1) by NCOMP and (0.69013hr-1) by equation, elimination half-life (1.00hr) and (1.0041hr), volume of distribution (18.17L\kg) and (17.5265L\kg), rate of clearness (10.32 L-1\hr\kg) and (12.0957 L-1\hr\kg), maximum concentration was (15.52 mg) and (15.521 mg). Conclusion: Caffeine pharmacokinetic study shows that caffeine excretes in saliva and has short half-life equal to one hr. |
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| ISSN: | 2958-0870 2959-5398 |
| DOI: | 10.55145/ajbms.2023.1.2.001 |