Good maternal and fetal outcomes of three consecutive pregnancies in a Mediterranean woman with Alport syndrome: a case report

Good maternal and fetal outcomes of three consecutive pregnancies in a Mediterranean woman with Alport syndrome: a case report

Background Alport syndrome is a rare inherited disorder affecting the glomerular basement membrane, manifested by hematuria and proteinuria that is commonly associated with ocular and hearing defects. There is limited information about the maternal and fetal outcomes of Alport syndrome in pregnancy....

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Bibliographic Details
Published in:Journal of medical case reports Vol. 16; no. 1; pp. 1 - 328
Main Authors: Rawashdeh, Hasan, Alchalabi, Haifaa A, Oweis, Ashraf O, Al Jalodi, Haneen
Format: Journal Article
Language:English
Published: London BioMed Central Ltd 01-09-2022
BioMed Central
BMC
Subjects:
Age
Alport syndrome
Amniotic fluid
Asymptomatic
Blood pressure
Blood proteins
Case Report
Case reports
Cesarean section
Collagen
Creatinine
Fetal outcome
Genetic aspects
Hearing loss
Hematuria
Hemoglobin
Hypertension
Kidney diseases
Maternal outcome
Mutation
Nephrology
Obstetrics
Preeclampsia
Pregnancy
Pregnant women
Prenatal care
Proteins
Ultrasonic imaging
Urine
Womens health
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Summary:Background Alport syndrome is a rare inherited disorder affecting the glomerular basement membrane, manifested by hematuria and proteinuria that is commonly associated with ocular and hearing defects. There is limited information about the maternal and fetal outcomes of Alport syndrome in pregnancy. Case presentation We describe a smooth course of pregnancy, a good maternal outcome, and a good fetal outcome in three consecutive pregnancies for a 35-year-old Mediterranean woman with Alport syndrome over a 10-year duration. Although there was a nephrotic range of progressive proteinuria in all her pregnancies, there was a prompt drop in proteinuria within 2 weeks of her deliveries. She has constantly shown a normal serum creatinine level and a normal serum protein level in all her pregnancies. Apart from a single episode of asymptomatic hypertension in her second pregnancy at 34 weeks of gestation that returned to a normal range immediately after delivery, she was normotensive antenatally and postnatally. She gave birth by cesarean section to three healthy newborns. Conclusions A normal prepregnancy creatinine level and a mild range of proteinuria in a patient with normotension, who is not on any medication, are associated with good maternal and fetal outcomes. Furthermore, successful pregnancy that is followed by a normal renal function test might suggest a favorable outcome for any future pregnancy. Keywords: Alport syndrome, Case report, Fetal outcome, Maternal outcome
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:1752-1947
1752-1947
DOI:10.1186/s13256-022-03565-7