Vitamin D status of mothers and their neonates in Kuwait

Background : There has been a resurgence of nutritional rickets in children in many developing countries and some of the developed countries. Children between 6 and 18 months old are commonly affected. In order to find out the association between vitamin D and rickets we studied the vitamin D status...

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Bibliographic Details
Published in:	Pediatrics international Vol. 47; no. 6; pp. 649 - 652
Main Authors:	Molla, Abdul Majid, Al Badawi, Mona, Hammoud, Majeda Sabri, Molla, Ayesha Majid, Shukkur, Mumtaz, Thalib, Lukman, Eliwa, Mahmoud S.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Pty 01-12-2005
Subjects:	Adult breast-fed infant Female Humans Infant, Newborn Kuwait Mothers sun exposure Vitamin D - analogs & derivatives Vitamin D - blood vitamin D deficiency vitamin D supplementation
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Summary:	Background : There has been a resurgence of nutritional rickets in children in many developing countries and some of the developed countries. Children between 6 and 18 months old are commonly affected. In order to find out the association between vitamin D and rickets we studied the vitamin D status of the neonates and their mothers in Kuwait. Methods : Two hundred and fourteen full‐term pregnant mothers and their neonates were selected from two hospitals in Kuwait. All mothers had normal vaginal delivery. On the day of delivery 2.5 mL of maternal blood and 2.5 mL of cord blood samples were withdrawn. Serum 25‐hydroxyvitamin D (25OHD) was determined in duplicate by radioimmunoassay using an Incstar kit. Quality control analyses were done using several between and within run experiments. Results : A total of 128 mother–neonate pairs were selected from the Al‐Adan hospital and 86 from the Maternity Hospital. The mean age and parity of the mothers were similar in both hospitals. The mean (± SD) 25OHD levels of the mothers and the neonates in the Adan hospital were 13.3 (6.5) ng/mL and 8.2 (6.5) ng/mL, respectively. The corresponding values in the Maternity Hospital were 17.6 (12.4) and 8.1 (7.3) ng/mL for the mothers and the neonate, respectively. Serum 25OHD of the mothers and their newborn infants were highly correlated (r = 0.790, P < 0.001). Conclusions : Results demonstrate that 40% of the mothers and 60% of the neonates are vitamin D deficient on the day of delivery. The vitamin D of the mothers and neonates are highly correlated (r = 0.790, P < 0.001).
Bibliography:	ArticleID:PED2141 istex:AF5445823692EB9327AFFD0FAF3F1276C8CBC0B1 ark:/67375/WNG-Z4CJZP76-2 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1328-8067 1442-200X
DOI:	10.1111/j.1442-200x.2005.02141.x